adisease

Showing entry for Thrombophilia

General Disease Information
BXGD Id	BXGD008202
Disease Name	Thrombophilia
Disease CUI Id	C0398623
MeSH Codes	C15
Disease Class Name	Hemic and Lymphatic Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001871
Human Phenotype Ontology Term	Abnormality of blood and blood-forming tissues
Disease Ontology Id	DOID:630 DOID:7
Disease Ontology Class Name	genetic disease; disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00767	BXGT003949	Acyl-CoA desaturase	6319	reviewed
O60674	BXGT004892	Tyrosine-protein kinase JAK2	3717	reviewed	Kinase
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
P00451	BXGT005545	Coagulation factor VIII	2157	reviewed	Enzyme
P00488	BXGT005552	Coagulation factor XIII A chain	2162	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00734	BXGT005630	Prothrombin	2147	reviewed	Enzyme
P00740	BXGT005634	Coagulation factor IX	2158	reviewed	Enzyme
P00742	BXGT005636	Coagulation factor X	2159	reviewed	Enzyme
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00748	BXGT005640	Coagulation factor XII	2161	reviewed	Enzyme
P00750	BXGT005642	Tissue-type plasminogen activator	5327	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01008	BXGT005713	Antithrombin-III	462	reviewed	Enzyme modulator
P01023	BXGT005718	Alpha-2-macroglobulin	2	reviewed	Enzyme modulator
P01024	BXGT005719	Complement C3	718	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02549	BXGT005890	Spectrin alpha chain, erythrocytic 1	6708	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02671	BXGT005914	Fibrinogen alpha chain	2243	reviewed
P02675	BXGT005916	Fibrinogen beta chain	2244	reviewed	Signaling
P02730	BXGT005935	Band 3 anion transport protein	6521	reviewed	Transporter
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02749	BXGT005941	Beta-2-glycoprotein 1	350	reviewed
P02768	BXGT005955	Serum albumin	213	reviewed	Transporter
P02775	BXGT005960	Platelet basic protein	5473	reviewed	Signaling
P03372	BXGT006059	Estrogen receptor	2099	reviewed	Nuclear receptor
P03951	BXGT006117	Coagulation factor XI	2160	reviewed	Enzyme
P04070	BXGT006143	Vitamin K-dependent protein C	5624	reviewed	Enzyme
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P05106	BXGT006315	Integrin beta-3	3690	reviewed	Receptor
P05120	BXGT006319	Plasminogen activator inhibitor 2	5055	reviewed	Enzyme modulator
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05155	BXGT006328	Plasma protease C1 inhibitor	710	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05546	BXGT006367	Heparin cofactor 2	3053	reviewed	Enzyme modulator
P06731	BXGT006488	Carcinoembryonic antigen-related cell adhesion molecule 5	1048	reviewed
P07204	BXGT006567	Thrombomodulin	7056	reviewed
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07237	BXGT006576	Protein disulfide-isomerase	5034	reviewed
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P07355	BXGT006609	Annexin A2	302	reviewed
P08603	BXGT006798	Complement factor H	3075	reviewed
P08697	BXGT006815	Alpha-2-antiplasmin	5345	reviewed	Enzyme modulator
P08758	BXGT006821	Annexin A5	308	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P08842	BXGT006830	Steryl-sulfatase	412	reviewed	Enzyme
P09211	BXGT006869	Glutathione S-transferase P	2950	reviewed
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10646	BXGT007598	Tissue factor pathway inhibitor	7035	reviewed	Enzyme modulator
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11498	BXGT007714	Pyruvate carboxylase, mitochondrial	5091	reviewed	Enzyme
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P12318	BXGT007799	Low affinity immunoglobulin gamma Fc region receptor II-a	2212	reviewed	Cell adhesion
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16109	BXGT008194	P-selectin	6403	reviewed
P16157	BXGT008203	Ankyrin-1	286	reviewed
P16442	BXGT008227	Histo-blood group ABO system transferase	28	reviewed	Enzyme
P16930	BXGT008272	Fumarylacetoacetase	2184	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17735	BXGT008335	Tyrosine aminotransferase	6898	reviewed
P18827	BXGT008427	Syndecan-1	6382	reviewed	Extracellular structure
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36955	BXGT009946	Pigment epithelium-derived factor	5176	reviewed	Enzyme modulator
P38398	BXGT010037	Breast cancer type 1 susceptibility protein	672	reviewed	Enzyme
P42898	BXGT010344	Methylenetetrahydrofolate reductase	4524	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
Q07021	BXGT012915	Complement component 1 Q subcomponent-binding protein, mitochondrial	708	reviewed
Q14002	BXGT013433	Carcinoembryonic antigen-related cell adhesion molecule 7	1087	reviewed
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q76LX8	BXGT016870	A disintegrin and metalloproteinase with thrombospondin motifs 13	11093	reviewed	Enzyme
Q7L266	BXGT016993	Isoaspartyl peptidase/L-asparaginase	80150	reviewed	Enzyme
Q96IY4	BXGT019678	Carboxypeptidase B2	1361	reviewed	Enzyme
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BQB6	BXGT020108	Vitamin K epoxide reductase complex subunit 1	79001	reviewed	Enzyme
Q9NR96	BXGT021181	Toll-like receptor 9	54106	reviewed
Q9UBK8	BXGT021655	Methionine synthase reductase	4552	reviewed
Q9UK55	BXGT021738	Protein Z-dependent protease inhibitor	51156	reviewed	Enzyme modulator
Q9UKU7	BXGT021749	Isobutyryl-CoA dehydrogenase, mitochondrial	27034	reviewed	Enzyme
Q9UM07	BXGT021771	Protein-arginine deiminase type-4	23569	reviewed
Q9UNN8	BXGT021791	Endothelial protein C receptor	10544	reviewed	Enzyme modulator
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
P09622	BXGT023116	Dihydrolipoyl dehydrogenase, mitochondrial	1738	reviewed	Enzyme
P40198	BXGT023750	Carcinoembryonic antigen-related cell adhesion molecule 3	1084	reviewed
Q9UIJ7	BXGT026029	GTP:AMP phosphotransferase AK3, mitochondrial	50808	reviewed	Kinase

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}