Showing entry for Elongation factor 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT007934
Protein NameElongation factor 2
Uniport IdP13639
GeneEEF2
Gene Id1938
DomainEFG_C; EFG_II; EFG_IV; GTP_EFTU; GTP_EFTU_D2
Pfam PF00679   PF14492   PF03764   PF00009   PF03144  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04152 AMPK signaling pathway
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
Biological Process GO:0014009 glial cell proliferation
Biological Process GO:0002244 hematopoietic progenitor cell differentiation
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:2000767 positive regulation of cytoplasmic translation
Biological Process GO:0045727 positive regulation of translation
Biological Process GO:0042493 response to drug
Biological Process GO:0034976 response to endoplasmic reticulum stress
Biological Process GO:0032355 response to estradiol
Biological Process GO:0045471 response to ethanol
Biological Process GO:0051593 response to folic acid
Biological Process GO:0042542 response to hydrogen peroxide
Biological Process GO:0002931 response to ischemia
Biological Process GO:0035914 skeletal muscle cell differentiation
Biological Process GO:0003009 skeletal muscle contraction
Biological Process GO:0006414 translational elongation
molecular function GO:0008097 5S rRNA binding
molecular function GO:0051015 actin filament binding
molecular function GO:0045296 cadherin binding
molecular function GO:0003924 GTPase activity
molecular function GO:0005525 GTP binding
molecular function GO:0002039 p53 binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0043022 ribosome binding
molecular function GO:0003723 RNA binding
molecular function GO:0003746 translation elongation factor activity
cellular component GO:0016235 aggresome
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005634 nucleus
cellular component GO:0005886 plasma membrane
cellular component GO:0042788 polysomal ribosome
cellular component GO:1990904 ribonucleoprotein complex
cellular component GO:0034774 secretory granule lumen
Reactome
Pathway Id Pathway Name
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-156842 Eukaryotic Translation Elongation
R-HSA-156902 Peptide chain elongation
R-HSA-156902 Peptide chain elongation
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-1643685 Disease
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins
R-HSA-392499 Metabolism of proteins
R-HSA-5336415 Uptake and function of diphtheria toxin
R-HSA-5339562 Uptake and actions of bacterial toxins
R-HSA-5358493 Synthesis of diphthamide-EEF2
R-HSA-5358493 Synthesis of diphthamide-EEF2
R-HSA-5663205 Infectious disease
R-HSA-597592 Post-translational protein modification
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-72766 Translation
R-HSA-72766 Translation
R-HSA-8876725 Protein methylation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0008055 BXGD000514 Chikungunya Fever Infections
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0012546 BXGD000776 Diphtheria Infections
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0023281 BXGD001628 Leishmaniasis Infections; Skin and Connective Tissue Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024305 BXGD001763 Lymphoma, Non-Hodgkin Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027626 BXGD002005 Neoplasm Invasiveness Pathological Conditions, Signs and Symptoms; Neoplasms
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0037316 BXGD002688 Sleep Deprivation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0086743 BXGD003308 Osteoarthrosis Deformans Musculoskeletal Diseases
C0149782 BXGD003365 Squamous cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0158252 BXGD003877 Intervertebral disc disorder Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0158266 BXGD003878 Intervertebral Disc Degeneration Musculoskeletal Diseases
C0205641 BXGD004093 Adenocarcinoma, Basal Cell Neoplasms
C0205642 BXGD004094 Adenocarcinoma, Oxyphilic Neoplasms
C0205643 BXGD004095 Carcinoma, Cribriform Neoplasms
C0205644 BXGD004096 Carcinoma, Granular Cell Neoplasms
C0205645 BXGD004097 Adenocarcinoma, Tubular Neoplasms
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0271531 BXGD006210 Pineal gland dysfunction
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0393525 BXGD008081 Progressive cerebellar ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0427190 BXGD008611 Ataxia, Truncal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520966 BXGD009128 Abnormal coordination Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0750937 BXGD010259 Ataxia, Appendicular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751837 BXGD010604 Gait Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1257931 BXGD011815 Mammary Neoplasms, Human Neoplasms; Skin and Connective Tissue Diseases
C1266042 BXGD011938 Chromophobe Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266043 BXGD011939 Sarcomatoid Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1266044 BXGD011940 Collecting Duct Carcinoma of the Kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1306837 BXGD012377 Papillary Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1836392 BXGD014111 Dysmetric saccades
C1836395 BXGD014113 SPINOCEREBELLAR ATAXIA 26 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1843885 BXGD014616 Progressive gait ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854494 BXGD015409 Slow progression
C1866753 BXGD016423 Impaired horizontal smooth pursuit
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931689 BXGD018049 Dystrophia myotonica 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C2986658 BXGD018234 Diffuse Intrinsic Pontine Glioma
C4024949 BXGD021496 Generalized hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4704874 BXGD023682 Mammary Carcinoma, Human Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0033776 Cycloheximide 281.16
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein