Showing entry for Potassium voltage-gated channel subfamily E member 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008116
Protein NamePotassium voltage-gated channel subfamily E member 1
Uniport IdP15382
GeneKCNE1
Gene Id3753
DomainISK_Channel
Pfam PF02060  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0086002 cardiac muscle cell action potential involved in contraction
Biological Process GO:0071320 cellular response to cAMP
Biological Process GO:0086009 membrane repolarization
Biological Process GO:0086011 membrane repolarization during action potential
Biological Process GO:0086013 membrane repolarization during cardiac muscle cell action potential
Biological Process GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential
Biological Process GO:1902260 negative regulation of delayed rectifier potassium channel activity
Biological Process GO:0090315 negative regulation of protein targeting to membrane
Biological Process GO:1901381 positive regulation of potassium ion transmembrane transport
Biological Process GO:0097623 potassium ion export across plasma membrane
Biological Process GO:0071805 potassium ion transmembrane transport
Biological Process GO:1902259 regulation of delayed rectifier potassium channel activity
Biological Process GO:0086091 regulation of heart rate by cardiac conduction
Biological Process GO:1901379 regulation of potassium ion transmembrane transport
Biological Process GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0086005 ventricular cardiac muscle cell action potential
molecular function GO:0005251 delayed rectifier potassium channel activity
molecular function GO:0044325 ion channel binding
molecular function GO:0015459 potassium channel regulator activity
molecular function GO:0031433 telethonin binding
cellular component GO:0016324 apical plasma membrane
cellular component GO:0009986 cell surface
cellular component GO:0005764 lysosome
cellular component GO:0045121 membrane raft
cellular component GO:0005886 plasma membrane
cellular component GO:0008076 voltage-gated potassium channel complex
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
R-HSA-397014 Muscle contraction
R-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576891 Cardiac conduction
R-HSA-5576893 Phase 2 - plateau phase
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003811 BXGD000222 Cardiac Arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004238 BXGD000262 Atrial Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007103 BXGD000426 Malignant neoplasm of endometrium Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013080 BXGD000797 Down Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0013363 BXGD000818 Dysautonomia Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0018781 BXGD001219 Noise-induced hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018790 BXGD001221 Cardiac Arrest Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020428 BXGD001377 Hyperaldosteronism Endocrine System Diseases
C0020621 BXGD001449 Hypokalemia Nutritional and Metabolic Diseases
C0022387 BXGD001543 Jervell-Lange Nielsen Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0022603 BXGD001565 Seborrheic keratosis Skin and Connective Tissue Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023976 BXGD001724 Long QT Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0025281 BXGD001848 Meniere Disease Otorhinolaryngologic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0035828 BXGD002566 Romano-Ward Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039070 BXGD002787 Syncope Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040188 BXGD002850 Tic disorder Nervous System Diseases; Mental Disorders
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0040479 BXGD002870 Torsades de Pointes Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0041657 BXGD002929 Unconscious State Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0042510 BXGD002987 Ventricular Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0042514 BXGD002989 Tachycardia, Ventricular Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085298 BXGD003155 Sudden Cardiac Death Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0085610 BXGD003202 Sinus bradycardia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0085612 BXGD003204 Ventricular arrhythmia Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0086132 BXGD003264 Depressive Symptoms Behavior and Behavior Mechanisms
C0151878 BXGD003495 Prolonged QT interval Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0152459 BXGD003600 Linear atrophy Pathological Conditions, Signs and Symptoms
C0162316 BXGD003936 Iron deficiency anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0175693 BXGD004001 Russell-Silver syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0202236 BXGD004086 Triglycerides measurement
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0264716 BXGD005417 Chronic heart failure Cardiovascular Diseases
C0268016 BXGD005802 Chronic hypokalemia Nutritional and Metabolic Diseases
C0268579 BXGD005995 Propionic acidemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0278076 BXGD006493 Behavioral tic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0337443 BXGD007161 Sodium measurement
C0339789 BXGD007282 Congenital deafness Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Nervous System Diseases; Otorhinolaryngologic Diseases
C0340489 BXGD007336 Lone atrial fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0403654 BXGD008302 Bladder outflow obstruction
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0429028 BXGD008646 QT interval feature (observable entity)
C0452138 BXGD008831 Sensorineural hearing loss, bilateral Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1141890 BXGD011721 Congenital long QT syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1142166 BXGD011736 Brugada Syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1560249 BXGD013361 Adverse Event Associated with Cardiac Arrhythmia
C1560305 BXGD013362 Prolonged QTc interval
C1563715 BXGD013389 Andersen Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1611743 BXGD013456 Familial (FPAH)
C1631597 BXGD013480 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1720983 BXGD013698 Channelopathies Pathological Conditions, Signs and Symptoms
C1839341 BXGD014370 Abnormal T-wave
C1843687 BXGD014602 ATRIAL FIBRILLATION, FAMILIAL, 1 (disorder) Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C1865866 BXGD016345 Congenital sensorineural hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1867904 BXGD016474 LONG QT SYNDROME 5 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1879645 BXGD016579 Adverse Event by CTCAE Category
C1963175 BXGD016687 Sinus Bradycardia, CTCAE
C1963217 BXGD016689 Prolonged QTc Interval, CTCAE
C2108107 BXGD016920 continuous electrocardiogram sinus bradycardia (finding)
C2169806 BXGD016935 recurrent muscle twitches (symptom) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2348199 BXGD017054 Short Qt Syndrome Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C2363741 BXGD017100 HIV-1 infection
C2676723 BXGD017341 JERVELL AND LANGE-NIELSEN SYNDROME 2 (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C2732413 BXGD017554 Postexertional fatigue Pathological Conditions, Signs and Symptoms
C2931783 BXGD018061 Amelogenesis imperfecta nephrocalcinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Stomatognathic Diseases
C3150852 BXGD018342 EARLY REPOLARIZATION ASSOCIATED WITH VENTRICULAR FIBRILLATION
C3150943 BXGD018362 Long Qt Syndrome 2 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C3150956 BXGD018363 LONG QT SYNDROME 5, ACQUIRED, SUSCEPTIBILITY TO
C3178805 BXGD018541 Heterotaxy Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C3711374 BXGD019382 Nonsyndromic Deafness Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4023338 BXGD021156 Profound sensorineural hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C4025797 BXGD021795 Abnormality of prenatal development or birth
C4477077 BXGD022917 Abnormal cardiac exercise stress test
C4521042 BXGD023055 Complete Trisomy 21 Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C4551509 BXGD023329 Jervell And Lange-Nielsen Syndrome 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4551647 BXGD023381 Long QT Syndrome 1 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002043 Acacetin 284.26
BXGC0042114 Solifenacin 362.2
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein