Showing entry for Arylsulfatase B


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008162
Protein NameArylsulfatase B
Uniport IdP15848
GeneARSB
Gene Id411
DomainSulfatase
Pfam PF00884  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.7 Glycan biosynthesis and metabolism hsa00531 Glycosaminoglycan degradation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006914 autophagy
Biological Process GO:0007417 central nervous system development
Biological Process GO:0030207 chondroitin sulfate catabolic process
Biological Process GO:0061580 colon epithelial cell migration
Biological Process GO:0007041 lysosomal transport
Biological Process GO:0007040 lysosome organization
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0010632 regulation of epithelial cell migration
Biological Process GO:0043627 response to estrogen
Biological Process GO:0051597 response to methylmercury
Biological Process GO:0007584 response to nutrient
Biological Process GO:0009268 response to pH
molecular function GO:0004065 arylsulfatase activity
molecular function GO:0046872 metal ion binding
molecular function GO:0003943 N-acetylgalactosamine-4-sulfatase activity
cellular component GO:0035578 azurophil granule lumen
cellular component GO:0009986 cell surface
cellular component GO:0005788 endoplasmic reticulum lumen
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:1904813 ficolin-1-rich granule lumen
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
cellular component GO:0005739 mitochondrion
cellular component GO:0005791 rough endoplasmic reticulum
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1630316 Glycosaminoglycan metabolism
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-1643685 Disease
R-HSA-1660662 Glycosphingolipid metabolism
R-HSA-1663150 The activation of arylsulfatases
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism
R-HSA-2024101 CS/DS degradation
R-HSA-2206281 Mucopolysaccharidoses
R-HSA-2206285 MPS VI - Maroteaux-Lamy syndrome
R-HSA-392499 Metabolism of proteins
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-5663084 Diseases of carbohydrate metabolism
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
R-HSA-6798695 Neutrophil degranulation
R-HSA-71387 Metabolism of carbohydrates
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002986 BXGD000165 Fabry Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005890 BXGD000345 Body Height
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007682 BXGD000471 CNS disorder Nervous System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009918 BXGD000636 Contracture of joint Musculoskeletal Diseases
C0010674 BXGD000683 Cystic Fibrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Respiratory Tract Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017921 BXGD001152 Glycogen storage disease type II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019294 BXGD001314 Hernia, Inguinal Pathological Conditions, Signs and Symptoms
C0019572 BXGD001338 Hirsutism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0020255 BXGD001369 Hydrocephalus Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023522 BXGD001680 Leukodystrophy, Metachromatic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023786 BXGD001697 Mucopolysaccharidosis I Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024408 BXGD001768 Machado-Joseph Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0024421 BXGD001770 Macroglossia Stomatognathic Diseases
C0025202 BXGD001832 melanoma Neoplasms
C0026703 BXGD001919 Mucopolysaccharidoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026706 BXGD001921 Mucopolysaccharidosis III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026707 BXGD001922 Mucopolysaccharidosis IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026709 BXGD001924 Mucopolysaccharidosis VI Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0027059 BXGD001965 Myocarditis Cardiovascular Diseases
C0027543 BXGD001997 Avascular necrosis of bone Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0037926 BXGD002712 Compression of spinal cord Nervous System Diseases; Wounds and Injuries
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0041296 BXGD002903 Tuberculosis Infections
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085660 BXGD003228 Aseptic necrosis Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C0086647 BXGD003298 Mucopolysaccharidosis Type IIIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0086651 BXGD003302 Mucopolysaccharidosis, MPS-IV-A Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0086795 BXGD003311 Pfaundler-Hurler Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0149645 BXGD003339 Cervical myelopathy Nervous System Diseases
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0201896 BXGD004055 Arylsulfatase B measurement
C0221355 BXGD004447 Macrocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0221358 BXGD004450 Long narrow head
C0221373 BXGD004454 Claw hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0238669 BXGD004952 Aortic root dilatation Cardiovascular Diseases
C0241654 BXGD005104 Abnormal heart valve morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0262380 BXGD005232 Asymptomatic bacteriuria Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C0266798 BXGD005715 Compression of umbilical cord Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0268218 BXGD005854 Maroteaux-Lamy syndrome, mild form Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0342751 BXGD007542 Generalized glycogen storage disease of infants Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0343386 BXGD007620 Clostridium difficile infection Infections
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0373721 BXGD007965 Selenium measurement
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0392476 BXGD008046 Epiphyseal dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0403397 BXGD008277 Steroid-resistant nephrotic syndrome Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0423250 BXGD008476 Corneal stromal opacities Eye Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0576093 BXGD009525 Knee joint valgus deformity Musculoskeletal Diseases
C0577631 BXGD009535 Carotid Atherosclerosis Nervous System Diseases; Cardiovascular Diseases
C0581381 BXGD009567 Recurrent upper respiratory tract infection Infections; Respiratory Tract Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306503 BXGD012363 Congenital exomphalos Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1836542 BXGD014129 Depressed nasal bridge
C1838662 BXGD014334 Metaphyseal irregularity
C1845847 BXGD014760 Coarse facial features Pathological Conditions, Signs and Symptoms
C1846433 BXGD014813 Prominent sternum
C1846435 BXGD014815 Disproportionate short-trunk short stature
C1846439 BXGD014817 Hypoplasia of the odontoid process Musculoskeletal Diseases
C1846442 BXGD014818 Hypoplastic acetabulae
C1848654 BXGD014958 Broad ribs
C1849039 BXGD014999 Metaphyseal widening
C1854774 BXGD015429 Dermatan sulfate excretion in urine
C1855665 BXGD015524 Ovoid vertebral bodies
C1858556 BXGD015805 OVERLAP CONNECTIVE TISSUE DISEASE Eye Diseases; Skin and Connective Tissue Diseases; Cardiovascular Diseases
C1865027 BXGD016287 Hypoplastic iliac wing
C1865841 BXGD016343 Flared iliac wings
C2985280 BXGD018223 Blood Protein Measurement
C3266102 BXGD018597 Steroid resistant nephrotic syndrome of childhood Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C3887513 BXGD019887 Avascular necrosis Pathological Conditions, Signs and Symptoms
C4017253 BXGD020426 MUCOPOLYSACCHARIDOSIS, TYPE VI, SEVERE
C4023009 BXGD021062 Constrictive median neuropathy Nervous System Diseases
C4023114 BXGD021112 Anterior wedging of L2
C4024677 BXGD021365 Anterior wedging of L1
C4553018 BXGD023532 Avascular Necrosis, CTCAE
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein