adisease

Showing entry for Joint stiffness

General Disease Information
BXGD Id	BXGD003933
Disease Name	Joint stiffness
Disease CUI Id	C0162298
MeSH Codes	C05
Disease Class Name	Musculoskeletal Diseases
Semantic Type	Sign or Symptom
Human Phenotype Ontology Id	HP:0000924
Human Phenotype Ontology Term	Abnormality of the skeletal system
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00238	BXGT003900	Bone morphogenetic protein receptor type-1B	658	reviewed	Kinase
O00469	BXGT003926	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	5352	reviewed	Enzyme
O14764	BXGT004094	Gamma-aminobutyric acid receptor subunit delta	2563	reviewed	Ion channel
O15357	BXGT004156	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	3636	reviewed
O43318	BXGT004586	Mitogen-activated protein kinase kinase kinase 7	6885	reviewed	Kinase
O75367	BXGT005117	Core histone macro-H2A.1	9555	reviewed	Nucleic acid binding
O75530	BXGT005135	Polycomb protein EED	8726	reviewed
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02458	BXGT005879	Collagen alpha-1(II) chain	1280	reviewed
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P08236	BXGT006752	Beta-glucuronidase	2990	reviewed
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15428	BXGT008121	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	3248	reviewed
P15848	BXGT008162	Arylsulfatase B	411	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21333	BXGT008638	Filamin-A	2316	reviewed
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P21802	BXGT008691	Fibroblast growth factor receptor 2	2263	reviewed	Kinase
P22314	BXGT008755	Ubiquitin-like modifier-activating enzyme 1	7317	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P23415	BXGT008864	Glycine receptor subunit alpha-1	2741	reviewed	Ion channel
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P36021	BXGT009893	Monocarboxylate transporter 8	6567	reviewed	Transporter
P43026	BXGT010351	Growth/differentiation factor 5	8200	reviewed	Signaling
P45452	BXGT010462	Collagenase 3	4322	reviewed	Enzyme
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P48167	BXGT010621	Glycine receptor subunit beta	2743	reviewed	Ion channel
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P49585	BXGT010712	Choline-phosphate cytidylyltransferase A	5130	reviewed
P49747	BXGT010732	Cartilage oligomeric matrix protein	1311	reviewed
P51688	BXGT010883	N-sulphoglucosamine sulphohydrolase	6448	reviewed	Enzyme
P53667	BXGT011008	LIM domain kinase 1	3984	reviewed	Kinase
P54802	BXGT011081	Alpha-N-acetylglucosaminidase	4669	reviewed
P58335	BXGT011233	Anthrax toxin receptor 2	118429	reviewed	Receptor
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P63261	BXGT011512	Actin, cytoplasmic 2	71	reviewed	Cellular structure
P98160	BXGT012228	Basement membrane-specific heparan sulfate proteoglycan core protein	3339	reviewed	Enzyme modulator
Q01968	BXGT012626	Inositol polyphosphate 5-phosphatase OCRL-1	4952	reviewed	Enzyme
Q03164	BXGT012700	Histone-lysine N-methyltransferase 2A	4297	reviewed
Q03431	BXGT012714	Parathyroid hormone/parathyroid hormone-related peptide receptor	5745	reviewed	G-protein coupled receptor
Q03468	BXGT012716	DNA excision repair protein ERCC-6	2074	reviewed
Q13303	BXGT013336	Voltage-gated potassium channel subunit beta-2	8514	reviewed	Ion channel
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q13510	BXGT013367	Acid ceramidase	427	reviewed	Enzyme
Q14191	BXGT013452	Werner syndrome ATP-dependent helicase	7486	reviewed	Enzyme
Q14683	BXGT013500	Structural maintenance of chromosomes protein 1A	8243	reviewed
Q15022	BXGT013523	Polycomb protein SUZ12	23512	reviewed	Nucleic acid binding
Q15910	BXGT013612	Histone-lysine N-methyltransferase EZH2	2146	reviewed	Epigenetic regulator
Q8NBK3	BXGT018538	Formylglycine-generating enzyme	285362	reviewed
Q92979	BXGT019402	Ribosomal RNA small subunit methyltransferase NEP1	10436	reviewed	Nucleic acid binding
Q96BZ9	BXGT019629	TBC1 domain family member 20	128637	reviewed
Q99593	BXGT019939	T-box transcription factor TBX5	6910	reviewed	Transcription factor
Q9BY41	BXGT020180	Histone deacetylase 8	55869	reviewed	Epigenetic regulator
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9NP72	BXGT021144	Ras-related protein Rab-18	22931	reviewed
Q9NQX3	BXGT021172	Gephyrin	10243	reviewed
Q9Y2R2	BXGT022243	Tyrosine-protein phosphatase non-receptor type 22	26191	reviewed
Q59FF6	BXGT023693	Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant	2074	unreviewed
P08123	BXGT024477	Collagen alpha-2(I) chain	1278	reviewed
O95140	BXGT024482	Mitofusin-2	9927	reviewed	Enzyme
Q96L73	BXGT024676	Histone-lysine N-methyltransferase, H3 lysine-36 specific	64324	reviewed	Epigenetic regulator
P51608	BXGT025073	Methyl-CpG-binding protein 2	4204	reviewed	Epigenetic regulator
P28715	BXGT025675	DNA repair protein complementing XP-G cells	2073	reviewed
P35250	BXGT025854	Replication factor C subunit 2	5982	reviewed	Enzyme
Q9UQE7	BXGT025899	Structural maintenance of chromosomes protein 3	9126	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}