adisease

Showing entry for Fabry Disease

General Disease Information
BXGD Id	BXGD000165
Disease Name	Fabry Disease
Disease CUI Id	C0002986
MeSH Codes	C16 C18 C10 C14
Disease Class Name	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0001574 HP:0001626
Human Phenotype Ontology Term	Abnormality of the integument; Abnormality of the cardiovascular system
Disease Ontology Id	DOID:0014667 DOID:630
Disease Ontology Class Name	disease of metabolism; genetic disease
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00462	BXGT003925	Beta-mannosidase	4126	reviewed	Enzyme
O15553	BXGT004181	Pyrin	4210	reviewed
O43451	BXGT004594	Maltase-glucoamylase, intestinal	8972	reviewed	Enzyme
P00742	BXGT005636	Coagulation factor X	2159	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P02462	BXGT005881	Collagen alpha-1(IV) chain	1282	reviewed
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02760	BXGT005948	Protein AMBP	259	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02775	BXGT005960	Platelet basic protein	5473	reviewed	Signaling
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04275	BXGT006180	von Willebrand factor	7450	reviewed	Enzyme modulator
P05164	BXGT006333	Myeloperoxidase	4353	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06280	BXGT006433	Alpha-galactosidase A	2717	reviewed
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08236	BXGT006752	Beta-glucuronidase	2990	reviewed
P09651	BXGT006913	Heterogeneous nuclear ribonucleoprotein A1	3178	reviewed
P0DMV8	BXGT007509	Heat shock 70 kDa protein 1A	3304	reviewed
P0DMV9	BXGT007510	Heat shock 70 kDa protein 1B	3304	reviewed
P10253	BXGT007550	Lysosomal alpha-glucosidase	2548	reviewed	Enzyme
P10619	BXGT007589	Lysosomal protective protein	5476	reviewed	Enzyme
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P14410	BXGT008009	Sucrase-isomaltase, intestinal	6476	reviewed	Enzyme
P15289	BXGT008102	Arylsulfatase A	410	reviewed	Enzyme
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15848	BXGT008162	Arylsulfatase B	411	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16581	BXGT008245	E-selectin	6401	reviewed
P17050	BXGT008277	Alpha-N-acetylgalactosaminidase	4668	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P19320	BXGT008470	Vascular cell adhesion protein 1	7412	reviewed
P20933	BXGT008618	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	175	reviewed	Enzyme
P21589	BXGT008669	5'-nucleotidase	4907	reviewed	Enzyme
P22304	BXGT008752	Iduronate 2-sulfatase	3423	reviewed
P22309	BXGT008753	UDP-glucuronosyltransferase 1-1	54658	reviewed
P22626	BXGT008787	Heterogeneous nuclear ribonucleoproteins A2/B1	3181	reviewed
P27169	BXGT009161	Serum paraoxonase/arylesterase 1	5444	reviewed
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P29475	BXGT009353	Nitric oxide synthase, brain	4842	reviewed
P31947	BXGT009589	14-3-3 protein sigma	2810	reviewed	Chaperone
P32119	BXGT009600	Peroxiredoxin-2	7001	reviewed	Enzyme
P32929	BXGT009682	Cystathionine gamma-lyase	1491	reviewed	Enzyme
P33681	BXGT009739	T-lymphocyte activation antigen CD80	941	reviewed
P33981	BXGT009744	Dual specificity protein kinase TTK	7272	reviewed	Kinase
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P41222	BXGT010237	Prostaglandin-H2 D-isomerase	5730	reviewed	Enzyme
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P54652	BXGT011064	Heat shock-related 70 kDa protein 2	3306	reviewed
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P80188	BXGT011882	Neutrophil gelatinase-associated lipocalin	3934	reviewed	Enzyme
P98164	BXGT012230	Low-density lipoprotein receptor-related protein 2	4036	reviewed
Q06187	BXGT012860	Tyrosine-protein kinase BTK	695	reviewed	Kinase
Q13075	BXGT013308	Baculoviral IAP repeat-containing protein 1	4671	reviewed
Q14108	BXGT013440	Lysosome membrane protein 2	950	reviewed	Receptor
Q15078	BXGT013534	Cyclin-dependent kinase 5 activator 1	8851	reviewed	Enzyme modulator
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16739	BXGT013663	Ceramide glucosyltransferase	7357	reviewed	Enzyme
Q2M385	BXGT014131	Macrophage-expressed gene 1 protein	219972	reviewed
Q9UGJ0	BXGT021683	5'-AMP-activated protein kinase subunit gamma-2	51422	reviewed	Enzyme modulator
Q9ULV0	BXGT021763	Unconventional myosin-Vb	4645	reviewed	Cellular structure
Q9UM47	BXGT021772	Neurogenic locus notch homolog protein 3	4854	reviewed
P16284	BXGT022972	Platelet endothelial cell adhesion molecule	5175	reviewed	Cell adhesion

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}