adisease

Showing entry for CNS disorder

General Disease Information
BXGD Id	BXGD000471
Disease Name	CNS disorder
Disease CUI Id	C0007682
MeSH Codes	C10
Disease Class Name	Nervous System Diseases
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id	HP:0000707
Human Phenotype Ontology Term	Abnormality of the nervous system
Disease Ontology Id	DOID:7
Disease Ontology Class Name	disease of anatomical entity
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
F7VJQ1	BXGT003310	Alternative prion protein	5621	reviewed
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14656	BXGT004080	Torsin-1A	1861	reviewed	Chaperone
O14733	BXGT004087	Dual specificity mitogen-activated protein kinase kinase 7	5609	reviewed	Kinase
O15118	BXGT004127	NPC intracellular cholesterol transporter 1	4864	reviewed	Transporter
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
O75173	BXGT005105	A disintegrin and metalloproteinase with thrombospondin motifs 4	9507	reviewed	Enzyme
O75460	BXGT005127	Serine/threonine-protein kinase/endoribonuclease IRE1	2081	reviewed	Kinase
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O94759	BXGT005327	Transient receptor potential cation channel subfamily M member 2	7226	reviewed	Ion channel
O94811	BXGT005336	Tubulin polymerization-promoting protein	11076	reviewed	Cellular structure
O95069	BXGT005348	Potassium channel subfamily K member 2	3776	reviewed	Ion channel
P00441	BXGT005540	Superoxide dismutase [Cu-Zn]	6647	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01009	BXGT005714	Alpha-1-antitrypsin	5265	reviewed	Enzyme modulator
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01031	BXGT005720	Complement C5	727	reviewed	Enzyme modulator
P01034	BXGT005721	Cystatin-C	1471	reviewed
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01911	BXGT005816	HLA class II histocompatibility antigen, DRB1-15 beta chain	3123	reviewed	Immune response
P02649	BXGT005909	Apolipoprotein E	348	reviewed
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P02774	BXGT005959	Vitamin D-binding protein	2638	reviewed	Transporter
P04035	BXGT006129	3-hydroxy-3-methylglutaryl-coenzyme A reductase	3156	reviewed
P04156	BXGT006156	Major prion protein	5621	reviewed
P04179	BXGT006163	Superoxide dismutase [Mn], mitochondrial	6648	reviewed	Enzyme
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05155	BXGT006328	Plasma protease C1 inhibitor	710	reviewed	Enzyme modulator
P05177	BXGT006336	Cytochrome P450 1A2	1544	reviewed	Enzyme
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05362	BXGT006350	Intercellular adhesion molecule 1	3383	reviewed
P06401	BXGT006436	Progesterone receptor	5241	reviewed	Nuclear receptor
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07225	BXGT006572	Vitamin K-dependent protein S	5627	reviewed
P07288	BXGT006591	Prostate-specific antigen	354	reviewed	Enzyme
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08473	BXGT006773	Neprilysin	4311	reviewed	Enzyme
P08670	BXGT006810	Vimentin	7431	reviewed
P08684	BXGT006812	Cytochrome P450 3A4	1576	reviewed	Enzyme
P08700	BXGT006816	Interleukin-3	3562	reviewed
P08908	BXGT006837	5-hydroxytryptamine receptor 1A	3350	reviewed	G-protein coupled receptor
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09038	BXGT006851	Fibroblast growth factor 2	2247	reviewed	Signaling
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10145	BXGT007542	Interleukin-8	3576	reviewed	Signaling
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10635	BXGT007595	Cytochrome P450 2D6	1565	reviewed
P10636	BXGT007596	Microtubule-associated protein tau	4137	reviewed
P11226	BXGT007675	Mannose-binding protein C	4153	reviewed	Receptor
P11712	BXGT007738	Cytochrome P450 2C9	1559	reviewed
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15153	BXGT008090	Ras-related C3 botulinum toxin substrate 2	5880	reviewed	Enzyme modulator
P15336	BXGT008109	Cyclic AMP-dependent transcription factor ATF-2	1386	reviewed	Transcription factor
P15529	BXGT008134	Membrane cofactor protein	4179	reviewed
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P15848	BXGT008162	Arylsulfatase B	411	reviewed
P15884	BXGT008166	Transcription factor 4	6925	reviewed	Transcription factor
P16070	BXGT008186	CD44 antigen	960	reviewed
P16278	BXGT008213	Beta-galactosidase	2720	reviewed	Enzyme
P16473	BXGT008234	Thyrotropin receptor	7253	reviewed	G-protein coupled receptor
P16671	BXGT008255	Platelet glycoprotein 4	948	reviewed	Receptor
P18074	BXGT008374	General transcription and DNA repair factor IIH helicase subunit XPD	2068	reviewed	Enzyme
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P20813	BXGT008603	Cytochrome P450 2B6	1555	reviewed
P21730	BXGT008687	C5a anaphylatoxin chemotactic receptor 1	728	reviewed	G-protein coupled receptor
P22303	BXGT008751	Acetylcholinesterase	43	reviewed	Enzyme
P22304	BXGT008752	Iduronate 2-sulfatase	3423	reviewed
P22736	BXGT008800	Nuclear receptor subfamily 4 group A member 1	3164	reviewed	Nuclear receptor
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P24387	BXGT008966	Corticotropin-releasing factor-binding protein	1393	reviewed	Signaling
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P25105	BXGT009021	Platelet-activating factor receptor	5724	reviewed	G-protein coupled receptor
P25116	BXGT009025	Proteinase-activated receptor 1	2149	reviewed	G-protein coupled receptor
P25774	BXGT009066	Cathepsin S	1520	reviewed	Enzyme
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27815	BXGT009208	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	5141	reviewed
P28223	BXGT009239	5-hydroxytryptamine receptor 2A	3356	reviewed	G-protein coupled receptor
P28329	BXGT009251	Choline O-acetyltransferase	1103	reviewed	Enzyme
P28335	BXGT009255	5-hydroxytryptamine receptor 2C	3358	reviewed	G-protein coupled receptor
P28907	BXGT009301	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	952	reviewed	Enzyme
P29274	BXGT009327	Adenosine receptor A2a	135	reviewed	G-protein coupled receptor
P29350	BXGT009335	Tyrosine-protein phosphatase non-receptor type 6	5777	reviewed
P30044	BXGT009395	Peroxiredoxin-5, mitochondrial	25824	reviewed
P30084	BXGT009398	Enoyl-CoA hydratase, mitochondrial	1892	reviewed	Enzyme
P30536	BXGT009435	Translocator protein	706	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35475	BXGT009837	Alpha-L-iduronidase	3425	reviewed	Enzyme
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P41145	BXGT010225	Kappa-type opioid receptor	4986	reviewed	G-protein coupled receptor
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43681	BXGT010407	Neuronal acetylcholine receptor subunit alpha-4	1137	reviewed	Ion channel
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48067	BXGT010619	Sodium- and chloride-dependent glycine transporter 1	6536	reviewed	Transporter
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P49419	BXGT010705	Alpha-aminoadipic semialdehyde dehydrogenase	501	reviewed	Enzyme
P49773	BXGT010741	Histidine triad nucleotide-binding protein 1	3094	reviewed	Enzyme
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50052	BXGT010768	Type-2 angiotensin II receptor	186	reviewed	G-protein coupled receptor
P51572	BXGT010859	B-cell receptor-associated protein 31	10134	reviewed	Transporter
P51681	BXGT010878	C-C chemokine receptor type 5	1234	reviewed	G-protein coupled receptor
P51688	BXGT010883	N-sulphoglucosamine sulphohydrolase	6448	reviewed	Enzyme
P52788	BXGT010953	Spermine synthase	6611	reviewed
P55055	BXGT011101	Oxysterols receptor LXR-beta	7376	reviewed	Nuclear receptor
P55072	BXGT011103	Transitional endoplasmic reticulum ATPase	7415	reviewed
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P55087	BXGT011105	Aquaporin-4	361	reviewed	Ion channel
P55786	BXGT011125	Puromycin-sensitive aminopeptidase	9520	reviewed	Enzyme
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P78325	BXGT011832	Disintegrin and metalloproteinase domain-containing protein 8	101	reviewed	Enzyme
Q01453	BXGT012588	Peripheral myelin protein 22	5376	reviewed	Cellular structure
Q01668	BXGT012605	Voltage-dependent L-type calcium channel subunit alpha-1D	776	reviewed	Ion channel
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q04912	BXGT012790	Macrophage-stimulating protein receptor	4486	reviewed	Kinase
Q05329	BXGT012814	Glutamate decarboxylase 2	2572	reviewed	Enzyme
Q07343	BXGT012926	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	5142	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q08499	BXGT012988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	5144	reviewed
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13255	BXGT013332	Metabotropic glutamate receptor 1	2911	reviewed	G-protein coupled receptor
Q13304	BXGT013337	Uracil nucleotide/cysteinyl leukotriene receptor	2840	reviewed	G-protein coupled receptor
Q13546	BXGT013372	Receptor-interacting serine/threonine-protein kinase 1	8737	reviewed	Kinase
Q14123	BXGT013445	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	5137	reviewed
Q14145	BXGT013448	Kelch-like ECH-associated protein 1	9817	reviewed
Q14831	BXGT013506	Metabotropic glutamate receptor 7	2917	reviewed	G-protein coupled receptor
Q14832	BXGT013507	Metabotropic glutamate receptor 3	2913	reviewed	G-protein coupled receptor
Q14833	BXGT013508	Metabotropic glutamate receptor 4	2914	reviewed	G-protein coupled receptor
Q15125	BXGT013543	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	10682	reviewed	Enzyme
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q5VZ30	BXGT015894	Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa)	2572	unreviewed
Q7L576	BXGT016995	Cytoplasmic FMR1-interacting protein 1	23191	reviewed	Enzyme modulator
Q8TDS5	BXGT018813	Oxoeicosanoid receptor 1	165140	reviewed	G-protein coupled receptor
Q8TDV0	BXGT018815	Probable G-protein coupled receptor 151	134391	reviewed	G-protein coupled receptor
Q92731	BXGT019366	Estrogen receptor beta	2100	reviewed	Nuclear receptor
Q92876	BXGT019388	Kallikrein-6	5653	reviewed	Enzyme
Q96D31	BXGT019635	Calcium release-activated calcium channel protein 1	84876	reviewed	Ion channel
Q96GD0	BXGT019665	Pyridoxal phosphate phosphatase	57026	reviewed	Enzyme
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q99250	BXGT019913	Sodium channel protein type 2 subunit alpha	6326	reviewed	Ion channel
Q99538	BXGT019931	Legumain	5641	reviewed	Enzyme
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99574	BXGT019936	Neuroserpin	5274	reviewed	Enzyme modulator
Q99685	BXGT019948	Monoglyceride lipase	11343	reviewed	Enzyme
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	10280	reviewed
Q99836	BXGT019970	Myeloid differentiation primary response protein MyD88	4615	reviewed	Enzyme modulator
Q9BZR6	BXGT020202	Reticulon-4 receptor	65078	reviewed
Q9H2X9	BXGT020459	Solute carrier family 12 member 5	57468	reviewed	Transporter
Q9NPG2	BXGT021155	Neuroglobin	58157	reviewed	Transporter
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9ULV1	BXGT021764	Frizzled-4	8322	reviewed	G-protein coupled receptor
Q9UM73	BXGT021773	ALK tyrosine kinase receptor	238	reviewed	Kinase
Q9UN36	BXGT021780	Protein NDRG2	57447	reviewed	Enzyme
Q9UNQ0	BXGT021792	ATP-binding cassette sub-family G member 2	9429	reviewed	Transporter
Q9Y233	BXGT022210	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	10846	reviewed
Q9Y271	BXGT022222	Cysteinyl leukotriene receptor 1	10800	reviewed	G-protein coupled receptor
Q9Y3Z3	BXGT022268	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	25939	reviewed
Q9Y572	BXGT022289	Receptor-interacting serine/threonine-protein kinase 3	11035	reviewed	Kinase
Q9Y5N1	BXGT022297	Histamine H3 receptor	11255	reviewed	G-protein coupled receptor
Q9Y617	BXGT022314	Phosphoserine aminotransferase	29968	reviewed
P00738	BXGT022874	Haptoglobin	3240	reviewed	Enzyme
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
Q16552	BXGT023419	Interleukin-17A	3605	reviewed
Q15583	BXGT024027	Homeobox protein TGIF1	7050	reviewed	Enzyme
P38646	BXGT024954	Stress-70 protein, mitochondrial	3313	reviewed
P25090	BXGT025102	N-formyl peptide receptor 2	2358	reviewed	G-protein coupled receptor
Q96RD7	BXGT025890	Pannexin-1	24145	reviewed	Ion channel
Q5BJF2	BXGT026107	Sigma intracellular receptor 2	27346	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}