Showing entry for Integrin beta-6


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008414
Protein NameIntegrin beta-6
Uniport IdP18564
GeneITGB6
Gene Id3694
DomainEGF_2; I-EGF_1; Integrin_beta; Integrin_b_cyt; Integrin_B_tail; PSI_integrin
Pfam PF07974   PF18372   PF08725   PF07965   PF00362   PF17205  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04151 PI3K-Akt signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04510 Focal adhesion
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04512 ECM-receptor interaction
4. Cellular Processes 4.5 Cell motility hsa04810 Regulation of actin cytoskeleton
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0033627 cell adhesion mediated by integrin
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0030198 extracellular matrix organization
Biological Process GO:0006954 inflammatory response
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:1901388 regulation of transforming growth factor beta activation
Biological Process GO:0038044 transforming growth factor-beta secretion
molecular function GO:0005178 integrin binding
molecular function GO:0038023 signaling receptor activity
molecular function GO:0001618 virus receptor activity
cellular component GO:0030054 cell junction
cellular component GO:0005813 centrosome
cellular component GO:0009897 external side of plasma membrane
cellular component GO:0005925 focal adhesion
cellular component GO:0034685 integrin alphav-beta6 complex
cellular component GO:0008305 integrin complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0043235 receptor complex
Reactome
Pathway Id Pathway Name
R-HSA-1474244 Extracellular matrix organization
R-HSA-1566948 Elastic fibre formation
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000178 ECM proteoglycans
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0000786 BXGD000010 Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications
C0000822 BXGD000012 Abortion, Tubal Female Urogenital Diseases and Pregnancy Complications
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002452 BXGD000116 Amelogenesis Imperfecta Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0008311 BXGD000526 Cholangitis Digestive System Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010034 BXGD000640 Corneal Diseases Eye Diseases
C0011351 BXGD000717 Dental Enamel Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0016052 BXGD001040 Fibromuscular Dysplasia Cardiovascular Diseases
C0016514 BXGD001066 Foot-and-Mouth Disease Infections; Animal Diseases
C0017638 BXGD001132 Glioma Neoplasms
C0020757 BXGD001466 Ichthyoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029607 BXGD002168 Other emphysema Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0031099 BXGD002282 Periodontitis Stomatognathic Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086565 BXGD003295 Liver Dysfunction Digestive System Diseases
C0149678 BXGD003346 Epstein-Barr Virus Infections Infections
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0221227 BXGD004411 Centriacinar Emphysema Respiratory Tract Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0221373 BXGD004454 Claw hand Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0238288 BXGD004905 Muscular Dystrophy, Facioscapulohumeral Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264393 BXGD005385 Panacinar Emphysema Respiratory Tract Diseases
C0266060 BXGD005617 Anterior open bite Stomatognathic Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0349588 BXGD007933 Short stature
C0399367 BXGD008238 Amelogenesis imperfecta local hypoplastic form Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0399376 BXGD008241 Amelogenesis Imperfecta, Type III Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0521158 BXGD009130 Recurrent tumor
C0524910 BXGD009248 Hepatitis C, Chronic Digestive System Diseases; Infections
C0541764 BXGD009259 Delayed bone age
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0796085 BXGD010796 Nance-Horan syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Stomatognathic Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0948896 BXGD011563 Primary hypogonadism Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C1857042 BXGD015669 Sparse scalp hair
C1860711 BXGD015995 Dental enamel pits
C1862863 BXGD016138 Sparse body hair
C1863008 BXGD016147 Yellow-brown discoloration of the teeth
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2350878 BXGD017086 Focal Emphysema Respiratory Tract Diseases
C2919142 BXGD017867 Short Stature, CTCAE
C2931280 BXGD017996 Perniola Krajewska Carnevale syndrome Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3495798 BXGD019003 Periodontal inflammation
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3830362 BXGD019751 Early Pregnancy Loss Female Urogenital Diseases and Pregnancy Complications
C4015557 BXGD020213 AMELOGENESIS IMPERFECTA, TYPE IH
C4021902 BXGD020833 Short corpus callosum
C4021956 BXGD020839 Aplasia/Hypoplasia of the eyebrow
C4025252 BXGD021607 Abnormal nasal morphology
C4281559 BXGD022411 FRONTOMETAPHYSEAL DYSPLASIA 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002586 Calcium 40.08
BXGC0002588 Magnesium 24.31
BXGC0018397 beta-1,4-mannan 180.06
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein