Showing entry for Cholesterol 7-alpha-monooxygenase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT008794
Protein NameCholesterol 7-alpha-monooxygenase
Uniport IdP22680
GeneCYP7A1
Gene Id1581
Domainp450
Pfam PF00067  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00120 Primary bile acid biosynthesis
1. Metabolism 1.3 Lipid metabolism hsa00140 Steroid hormone biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.2 Endocrine system hsa03320 PPAR signaling pathway
5. Organismal Systems 5.4 Digestive system hsa04976 Bile secretion
5. Organismal Systems 5.4 Digestive system hsa04979 Cholesterol metabolism
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0015721 bile acid and bile salt transport
Biological Process GO:0006699 bile acid biosynthetic process
Biological Process GO:0038183 bile acid signaling pathway
Biological Process GO:0071397 cellular response to cholesterol
Biological Process GO:0071333 cellular response to glucose stimulus
Biological Process GO:0006707 cholesterol catabolic process
Biological Process GO:0042632 cholesterol homeostasis
Biological Process GO:0032966 negative regulation of collagen biosynthetic process
Biological Process GO:0045717 negative regulation of fatty acid biosynthetic process
Biological Process GO:0045542 positive regulation of cholesterol biosynthetic process
Biological Process GO:0070857 regulation of bile acid biosynthetic process
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0019216 regulation of lipid metabolic process
Biological Process GO:0045471 response to ethanol
Biological Process GO:0016125 sterol metabolic process
molecular function GO:0008123 cholesterol 7-alpha-monooxygenase activity
molecular function GO:0020037 heme binding
molecular function GO:0005506 iron ion binding
molecular function GO:0008395 steroid hydroxylase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-1989781 PPARA activates gene expression
R-HSA-211859 Biological oxidations
R-HSA-211897 Cytochrome P450 - arranged by substrate type
R-HSA-211945 Phase I - Functionalization of compounds
R-HSA-211976 Endogenous sterols
R-HSA-400206 Regulation of lipid metabolism by PPARalpha
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001306 BXGD000037 Acute alcoholic liver disease Digestive System Diseases; Chemically-Induced Disorders; Mental Disorders
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0005398 BXGD000311 Cholestasis, Extrahepatic Digestive System Diseases
C0005411 BXGD000313 Biliary Atresia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0008312 BXGD000527 Primary biliary cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010823 BXGD000690 Cytomegalovirus Infections Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0015695 BXGD001013 Fatty Liver Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016978 BXGD001087 gallbladder neoplasm Digestive System Diseases; Neoplasms
C0017495 BXGD001111 Gerstmann-Straussler-Scheinker Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Nervous System Diseases
C0019158 BXGD001293 Hepatitis Digestive System Diseases
C0019187 BXGD001296 Hepatitis, Alcoholic Digestive System Diseases; Chemically-Induced Disorders
C0020443 BXGD001385 Hypercholesterolemia Nutritional and Metabolic Diseases
C0020445 BXGD001386 Hypercholesterolemia, Familial Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020474 BXGD001397 Hyperlipidemia, Familial Combined Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020557 BXGD001432 Hypertriglyceridemia Nutritional and Metabolic Diseases
C0022638 BXGD001567 Ketosis Nutritional and Metabolic Diseases
C0023465 BXGD001656 Acute monocytic leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023895 BXGD001717 Liver diseases Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027873 BXGD002054 Neuromyelitis Optica Eye Diseases; Immune System Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029438 BXGD002148 Massive Osteolyses Musculoskeletal Diseases
C0041296 BXGD002903 Tuberculosis Infections
C0042870 BXGD003008 Vitamin D Deficiency Nutritional and Metabolic Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0206624 BXGD004190 Hepatoblastoma Neoplasms
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0242216 BXGD005141 Biliary calculi Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0345905 BXGD007746 Intrahepatic Cholangiocarcinoma Neoplasms
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0393591 BXGD008102 AICARDI-GOUTIERES SYNDROME Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Immune System Diseases; Nervous System Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0549399 BXGD009376 Low density lipoprotein increased Nutritional and Metabolic Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0742395 BXGD010062 Cholestasis, chronic
C0745103 BXGD010114 Hyperlipoproteinemia Type IIa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0856727 BXGD011108 Cholesterol gallstones Digestive System Diseases
C0860204 BXGD011219 Cholestatic liver disease Digestive System Diseases
C0860207 BXGD011220 Drug-Induced Liver Disease Digestive System Diseases; Chemically-Induced Disorders
C0947622 BXGD011493 Cholecystolithiasis Digestive System Diseases
C1302401 BXGD012303 Adenoma of large intestine Digestive System Diseases; Neoplasms
C1445957 BXGD013081 Serum total cholesterol measurement
C1837256 BXGD014212 Macrovesicular hepatic steatosis Digestive System Diseases
C1849618 BXGD015072 Accelerated atherosclerosis Cardiovascular Diseases
C1856058 BXGD015568 HOMOCYSTINURIA DUE TO DEFICIENCY OF N(5,10)-METHYLENETETRAHYDROFOLATE REDUCTASE ACTIVITY
C1856061 BXGD015570 Methylenetetrahydrofolate reductase deficiency Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C2712907 BXGD017491 obsolete Combined hyperlipidemia
C3151147 BXGD018400 Bile Acid Synthesis Defect, Congenital, 3 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Nutritional and Metabolic Diseases
C4022034 BXGD020877 Abnormality of vitamin E metabolism
C4024686 BXGD021369 Abnormality of vitamin A metabolism
C4025020 BXGD021527 Acute hepatic steatosis Digestive System Diseases
C4284013 BXGD022428 Primary cholangiocarcinoma of intrahepatic biliary tract Neoplasms
C4520983 BXGD023052 Congenital atresia of extrahepatic bile duct Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
C4751204 BXGD024082 Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency Nutritional and Metabolic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0008676 Haem 616.49
BXGC0042999 4-Cholesten 3-One 384.34
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein