Showing entry for Premature Menopause


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001863
Disease NamePremature Menopause
Disease CUI IdC0025322
MeSH Codes C13  
Disease Class NameFemale Urogenital Diseases and Pregnancy Complications
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000119  
Human Phenotype Ontology TermAbnormality of the genitourinary system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00238 BXGT003900 Bone morphogenetic protein receptor type-1B 658 reviewed Kinase
O00264 BXGT003904 Membrane-associated progesterone receptor component 1 10857 reviewed Signaling
O00329 BXGT003909 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 5293 reviewed Kinase
O00571 BXGT003938 ATP-dependent RNA helicase DDX3X 1654 reviewed
O14746 BXGT004091 Telomerase reverse transcriptase 7015 reviewed Enzyme
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 5170 reviewed Kinase
O43524 BXGT004599 Forkhead box protein O3 2309 reviewed
O60674 BXGT004892 Tyrosine-protein kinase JAK2 3717 reviewed Kinase
O75460 BXGT005127 Serine/threonine-protein kinase/endoribonuclease IRE1 2081 reviewed Kinase
O94907 BXGT005340 Dickkopf-related protein 1 22943 reviewed
O95267 BXGT005368 RAS guanyl-releasing protein 1 10125 reviewed Enzyme modulator
P00167 BXGT005473 Cytochrome b5 1528 reviewed Enzyme
P00740 BXGT005634 Coagulation factor IX 2158 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01236 BXGT005744 Prolactin 5617 reviewed Signaling
P01275 BXGT005747 Glucagon 2641 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01911 BXGT005816 HLA class II histocompatibility antigen, DRB1-15 beta chain 3123 reviewed Immune response
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02768 BXGT005955 Serum albumin 213 reviewed Transporter
P02774 BXGT005959 Vitamin D-binding protein 2638 reviewed Transporter
P03372 BXGT006059 Estrogen receptor 2099 reviewed Nuclear receptor
P04035 BXGT006129 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3156 reviewed
P04278 BXGT006182 Sex hormone-binding globulin 6462 reviewed
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P06493 BXGT006445 Cyclin-dependent kinase 1 983 reviewed Kinase
P07202 BXGT006565 Thyroid peroxidase 7173 reviewed Enzyme
P07288 BXGT006591 Prostate-specific antigen 354 reviewed Enzyme
P07333 BXGT006602 Macrophage colony-stimulating factor 1 receptor 1436 reviewed Kinase
P07902 BXGT006697 Galactose-1-phosphate uridylyltransferase 2592 reviewed Enzyme
P08253 BXGT006757 72 kDa type IV collagenase 4313 reviewed Enzyme
P09172 BXGT006865 Dopamine beta-hydroxylase 1621 reviewed
P09382 BXGT006882 Galectin-1 3956 reviewed Signaling
P09874 BXGT006934 Poly [ADP-ribose] polymerase 1 142 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10721 BXGT007605 Mast/stem cell growth factor receptor Kit 3815 reviewed Kinase
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P11717 BXGT007740 Cation-independent mannose-6-phosphate receptor 3482 reviewed Receptor
P12643 BXGT007830 Bone morphogenetic protein 2 650 reviewed Signaling
P15692 BXGT008147 Vascular endothelial growth factor A 7422 reviewed Signaling
P16471 BXGT008233 Prolactin receptor 5618 reviewed Signaling
P19544 BXGT008494 Wilms tumor protein 7490 reviewed Nucleic acid binding
P19883 BXGT008528 Follistatin 10468 reviewed Enzyme modulator
P20813 BXGT008603 Cytochrome P450 2B6 1555 reviewed
P21453 BXGT008654 Sphingosine 1-phosphate receptor 1 1901 reviewed G-protein coupled receptor
P21583 BXGT008667 Kit ligand 4254 reviewed
P21953 BXGT008711 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 594 reviewed Enzyme
P21964 BXGT008714 Catechol O-methyltransferase 1312 reviewed Enzyme
P22680 BXGT008794 Cholesterol 7-alpha-monooxygenase 1581 reviewed Enzyme
P23560 BXGT008883 Brain-derived neurotrophic factor 627 reviewed Signaling
P23945 BXGT008931 Follicle-stimulating hormone receptor 2492 reviewed G-protein coupled receptor
P25440 BXGT009044 Bromodomain-containing protein 2 6046 reviewed Epigenetic regulator
P27635 BXGT009194 60S ribosomal protein L10 6134 reviewed Nucleic acid binding
P28907 BXGT009301 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 952 reviewed Enzyme
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase 207 reviewed Kinase
P32119 BXGT009600 Peroxiredoxin-2 7001 reviewed Enzyme
P33261 BXGT009707 Cytochrome P450 2C19 1557 reviewed
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 3791 reviewed Kinase
P37173 BXGT009970 TGF-beta receptor type-2 7048 reviewed Kinase
P38398 BXGT010037 Breast cancer type 1 susceptibility protein 672 reviewed Enzyme
P42336 BXGT010302 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 5290 reviewed Kinase
P42338 BXGT010303 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 5291 reviewed Kinase
P42345 BXGT010304 Serine/threonine-protein kinase mTOR 2475 reviewed Kinase
P42898 BXGT010344 Methylenetetrahydrofolate reductase 4524 reviewed
P46527 BXGT010525 Cyclin-dependent kinase inhibitor 1B 1027 reviewed
P46531 BXGT010526 Neurogenic locus notch homolog protein 1 4851 reviewed
P47712 BXGT010577 Cytosolic phospholipase A2 5321 reviewed Enzyme
P48023 BXGT010604 Tumor necrosis factor ligand superfamily member 6 356 reviewed Signaling
P48061 BXGT010616 Stromal cell-derived factor 1 6387 reviewed
P48736 BXGT010658 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 5294 reviewed Kinase
P49146 BXGT010681 Neuropeptide Y receptor type 2 4887 reviewed G-protein coupled receptor
P49642 BXGT010721 DNA primase small subunit 5557 reviewed Enzyme
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P54098 BXGT011030 DNA polymerase subunit gamma-1 5428 reviewed Enzyme
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P60568 BXGT011315 Interleukin-2 3558 reviewed
P60709 BXGT011322 Actin, cytoplasmic 1 60 reviewed Cellular structure
P61073 BXGT011352 C-X-C chemokine receptor type 4 7852 reviewed G-protein coupled receptor
P98177 BXGT012232 Forkhead box protein O4 4303 reviewed
Q03468 BXGT012716 DNA excision repair protein ERCC-6 2074 reviewed
Q04721 BXGT012777 Neurogenic locus notch homolog protein 2 4853 reviewed
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q07812 BXGT012940 Apoptosis regulator BAX 581 reviewed Signaling
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13133 BXGT013315 Oxysterols receptor LXR-alpha 10062 reviewed Nuclear receptor
Q13144 BXGT013317 Translation initiation factor eIF-2B subunit epsilon 8893 reviewed
Q13285 BXGT013335 Steroidogenic factor 1 2516 reviewed Nuclear receptor
Q13309 BXGT013338 S-phase kinase-associated protein 2 6502 reviewed
Q13705 BXGT013393 Activin receptor type-2B 93 reviewed Kinase
Q13873 BXGT013398 Bone morphogenetic protein receptor type-2 659 reviewed Kinase
Q14232 BXGT013457 Translation initiation factor eIF-2B subunit alpha 1967 reviewed
Q14565 BXGT013484 Meiotic recombination protein DMC1/LIM15 homolog 11144 reviewed
Q14671 BXGT013496 Pumilio homolog 1 9698 reviewed Nucleic acid binding
Q15031 BXGT013525 Probable leucine--tRNA ligase, mitochondrial 23395 reviewed Enzyme
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q53EL6 BXGT015008 Programmed cell death protein 4 27250 reviewed Nucleic acid binding
Q5JTZ9 BXGT015458 Alanine--tRNA ligase, mitochondrial 57505 reviewed Nucleic acid binding
Q6ZN16 BXGT016630 Mitogen-activated protein kinase kinase kinase 15 389840 reviewed
Q7Z494 BXGT017254 Nephrocystin-3 27031 reviewed
Q8TDC3 BXGT018808 Serine/threonine-protein kinase BRSK1 84446 reviewed Kinase
Q92731 BXGT019366 Estrogen receptor beta 2100 reviewed Nuclear receptor
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96RI1 BXGT019727 Bile acid receptor 9971 reviewed Nuclear receptor
Q9BWD1 BXGT020152 Acetyl-CoA acetyltransferase, cytosolic 39 reviewed Enzyme
Q9H251 BXGT020449 Cadherin-23 64072 reviewed
Q9NP79 BXGT021145 Vacuolar protein sorting-associated protein VTA1 homolog 51534 reviewed
Q9NRA8 BXGT021184 Eukaryotic translation initiation factor 4E transporter 56478 reviewed
Q9P0U3 BXGT021292 Sentrin-specific protease 1 29843 reviewed Enzyme
Q9UBK8 BXGT021655 Methionine synthase reductase 4552 reviewed
Q9UKI8 BXGT021743 Serine/threonine-protein kinase tousled-like 1 9874 reviewed Kinase
Q9UQ84 BXGT021807 Exonuclease 1 9156 reviewed Enzyme
Q01995 BXGT022678 Transgelin 6876 reviewed Cellular structure
Q59FF6 BXGT023693 Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant 2074 unreviewed
O60232 BXGT024169 Protein ZNRD2 10534 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease