Showing entry for Valine--tRNA ligase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009123
Protein NameValine--tRNA ligase
Uniport IdP26640
GeneVARS1
Gene Id7407
DomainAnticodon_1; GST_C; tRNA-synt_1
Pfam PF08264   PF00043   PF00133  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.2 Translation hsa00970 Aminoacyl-tRNA biosynthesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006418 tRNA aminoacylation for protein translation
Biological Process GO:0006438 valyl-tRNA aminoacylation
molecular function GO:0002161 aminoacyl-tRNA editing activity
molecular function GO:0005524 ATP binding
molecular function GO:0004832 valine-tRNA ligase activity
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379724 tRNA Aminoacylation
R-HSA-392499 Metabolism of proteins
R-HSA-72766 Translation
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004106 BXGD000254 Astigmatism Eye Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0027092 BXGD001971 Myopia Eye Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0036202 BXGD002581 Sarcoidosis Hemic and Lymphatic Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085543 BXGD003181 Epilepsia Partialis Continua Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0200637 BXGD004042 Monocyte count procedure
C0201899 BXGD004056 Aspartate aminotransferase measurement
C0239234 BXGD004974 Low set ears
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0428883 BXGD008639 Diastolic blood pressure
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0543888 BXGD009300 Epileptic encephalopathy Nervous System Diseases
C0557874 BXGD009444 Global developmental delay
C0740279 BXGD009973 Cerebellar atrophy
C0750880 BXGD010239 Monocyte count result
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1836542 BXGD014129 Depressed nasal bridge
C1850456 BXGD015146 Progressive microcephaly
C1853738 BXGD015357 Long eyelashes
C1854114 BXGD015383 Short nose
C1857679 BXGD015735 Sloping forehead
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859455 BXGD015893 Small anterior fontanelle
C3161330 BXGD018511 Profound intellectual disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021085 BXGD020544 Abnormality of brain morphology
C4540493 BXGD023264 NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, SEIZURES, AND CORTICAL ATROPHY
C4551563 BXGD023351 Microcephaly (physical finding)
C4551583 BXGD023361 Cerebral cortical atrophy
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003205 (+)-Valine 117.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein