Showing entry for Heme oxygenase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009429
Protein NameHeme oxygenase 2
Uniport IdP30519
GeneHMOX2
Gene Id3163
DomainHeme_oxygenase
Pfam PF01126  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00860 Porphyrin and chlorophyll metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.4 Digestive system hsa04978 Mineral absorption
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006879 cellular iron ion homeostasis
Biological Process GO:0042167 heme catabolic process
Biological Process GO:0006788 heme oxidation
Biological Process GO:0055072 iron ion homeostasis
Biological Process GO:0043312 neutrophil degranulation
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0006979 response to oxidative stress
molecular function GO:0020037 heme binding
molecular function GO:0004392 heme oxygenase (decyclizing) activity
molecular function GO:0046872 metal ion binding
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0016020 membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0035579 specific granule membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-189445 Metabolism of porphyrins
R-HSA-189483 Heme degradation
R-HSA-382551 Transport of small molecules
R-HSA-6798695 Neutrophil degranulation
R-HSA-917937 Iron uptake and transport
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002736 BXGD000127 Amyotrophic Lateral Sclerosis Nutritional and Metabolic Diseases; Nervous System Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007786 BXGD000486 Brain Ischemia Nervous System Diseases; Cardiovascular Diseases
C0007787 BXGD000487 Transient Ischemic Attack Nervous System Diseases; Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0020452 BXGD001389 Hyperemia Cardiovascular Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023440 BXGD001646 Acute Erythroblastic Leukemia Neoplasms; Hemic and Lymphatic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035258 BXGD002523 Restless Legs Syndrome Nervous System Diseases; Mental Disorders
C0037315 BXGD002687 Sleep Apnea Syndromes Respiratory Tract Diseases; Nervous System Diseases
C0038454 BXGD002760 Cerebrovascular accident Nervous System Diseases; Cardiovascular Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0270736 BXGD006096 Essential Tremor Nervous System Diseases
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0917805 BXGD011414 Transient Cerebral Ischemia Nervous System Diseases; Cardiovascular Diseases
C1258666 BXGD011825 Myxoid cyst Neoplasms; Skin and Connective Tissue Diseases
C1270972 BXGD012006 Mild cognitive disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C2347748 BXGD017041 Adult Erythroleukemia
C2937358 BXGD018159 Cerebral Hemorrhage Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C4520840 BXGD023041 Erythroleukemia (Erythroid/Myeloid) Neoplasms; Hemic and Lymphatic Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002144 Tetradecanoic acid 228.37
BXGC0002248 Dodecanoic acid 200.32
BXGC0003705 Chloride 35.45
BXGC0008676 Haem 616.49
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein