Showing entry for Restless Legs Syndrome


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002523
Disease NameRestless Legs Syndrome
Disease CUI IdC0035258
MeSH Codes C10   F03  
Disease Class NameNervous System Diseases; Mental Disorders
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000707  
Human Phenotype Ontology TermAbnormality of the nervous system
Disease Ontology Id DOID:7  
Disease Ontology Class Namedisease of anatomical entity
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
A8MPY1 BXGT001712 Gamma-aminobutyric acid receptor subunit rho-3 200959 reviewed Ion channel
O43464 BXGT004595 Serine protease HTRA2, mitochondrial 27429 reviewed
O60260 BXGT004864 E3 ubiquitin-protein ligase parkin 5071 reviewed Enzyme
P00325 BXGT005498 Alcohol dehydrogenase 1B 125 reviewed Enzyme
P00797 BXGT005658 Renin 5972 reviewed Enzyme
P01009 BXGT005714 Alpha-1-antitrypsin 5265 reviewed Enzyme modulator
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01042 BXGT005722 Kininogen-1 3827 reviewed Enzyme modulator
P01189 BXGT005742 Pro-opiomelanocortin 5443 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02741 BXGT005936 C-reactive protein 1401 reviewed
P02786 BXGT005961 Transferrin receptor protein 1 7037 reviewed Enzyme
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P02792 BXGT005966 Ferritin light chain 2512 reviewed Storage
P04818 BXGT006269 Thymidylate synthase 7298 reviewed Enzyme
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P11473 BXGT007709 Vitamin D3 receptor 7421 reviewed Nuclear receptor
P14416 BXGT008011 D(2) dopamine receptor 1813 reviewed G-protein coupled receptor
P21397 BXGT008644 Amine oxidase [flavin-containing] A 4128 reviewed
P21917 BXGT008707 D(4) dopamine receptor 1815 reviewed G-protein coupled receptor
P23468 BXGT008870 Receptor-type tyrosine-protein phosphatase delta 5789 reviewed Enzyme
P27338 BXGT009172 Amine oxidase [flavin-containing] B 4129 reviewed
P27708 BXGT009202 CAD protein 790 reviewed Enzyme
P28476 BXGT009262 Gamma-aminobutyric acid receptor subunit rho-2 2570 reviewed Ion channel
P29475 BXGT009353 Nitric oxide synthase, brain 4842 reviewed
P30519 BXGT009429 Heme oxygenase 2 3163 reviewed
P30793 BXGT009466 GTP cyclohydrolase 1 2643 reviewed Enzyme
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P35462 BXGT009835 D(3) dopamine receptor 1814 reviewed G-protein coupled receptor
P37840 BXGT010015 Alpha-synuclein 6622 reviewed Transporter
P43004 BXGT010348 Excitatory amino acid transporter 2 6506 reviewed Transporter
P46939 BXGT010555 Utrophin 7402 reviewed
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 2557 reviewed Ion channel
P49281 BXGT010689 Natural resistance-associated macrophage protein 2 4891 reviewed Transporter
P50135 BXGT010776 Histamine N-methyltransferase 3176 reviewed
P81172 BXGT011935 Hepcidin 57817 reviewed
P98164 BXGT012230 Low-density lipoprotein receptor-related protein 2 4036 reviewed
Q01538 BXGT012597 Myelin transcription factor 1 4661 reviewed Transcription factor
Q01959 BXGT012624 Sodium-dependent dopamine transporter 6531 reviewed Transporter
Q04760 BXGT012782 Lactoylglutathione lyase 2739 reviewed
Q06787 BXGT012890 Synaptic functional regulator FMR1 2332 reviewed Nucleic acid binding
Q13163 BXGT013321 Dual specificity mitogen-activated protein kinase kinase 5 5607 reviewed Kinase
Q15599 BXGT013583 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 9351 reviewed
Q16595 BXGT013643 Frataxin, mitochondrial 2395 reviewed Enzyme
Q30201 BXGT014297 Hereditary hemochromatosis protein 3077 reviewed
Q5S007 BXGT015650 Leucine-rich repeat serine/threonine-protein kinase 2 120892 reviewed Kinase
Q86SZ2 BXGT017602 Trafficking protein particle complex subunit 6B 122553 reviewed
Q8WXF7 BXGT019011 Atlastin-1 51062 reviewed Enzyme modulator
Q96EN8 BXGT019649 Molybdenum cofactor sulfurase 55034 reviewed
Q99497 BXGT019926 Protein/nucleic acid deglycase DJ-1 11315 reviewed Enzyme
Q99700 BXGT019949 Ataxin-2 6311 reviewed Nucleic acid binding
Q9BXM7 BXGT020172 Serine/threonine-protein kinase PINK1, mitochondrial 65018 reviewed Kinase
Q9Y259 BXGT022219 Choline/ethanolamine kinase 1120 reviewed Kinase
O43148 BXGT023017 mRNA cap guanine-N7 methyltransferase 8731 reviewed
Q16552 BXGT023419 Interleukin-17A 3605 reviewed
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease