protein

Showing entry for Peroxisome proliferator-activated receptor gamma

General Target Information
BXGT Id	BXGT009974
Protein Name	Peroxisome proliferator-activated receptor gamma
Uniport Id	P37238
Gene	Pparg
Gene Id	19016
Domain	Hormone_recep; PPARgamma_N; zf-C4
Pfam	PF00104 PF12577 PF00105
Organism	Mus musculus (Mouse)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process	GO:0050873	brown fat cell differentiation
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0045165	cell fate commitment
Biological Process	GO:0048469	cell maturation
Biological Process	GO:0032869	cellular response to insulin stimulus
Biological Process	GO:0071285	cellular response to lithium ion
Biological Process	GO:0071404	cellular response to low-density lipoprotein particle stimulus
Biological Process	GO:0071407	cellular response to organic cyclic compound
Biological Process	GO:0002024	diet induced thermogenesis
Biological Process	GO:0030855	epithelial cell differentiation
Biological Process	GO:0045444	fat cell differentiation
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0019395	fatty acid oxidation
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0009755	hormone-mediated signaling pathway
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0042953	lipoprotein transport
Biological Process	GO:0015909	long-chain fatty acid transport
Biological Process	GO:0045713	low-density lipoprotein particle receptor biosynthetic process
Biological Process	GO:0010742	macrophage derived foam cell differentiation
Biological Process	GO:0030224	monocyte differentiation
Biological Process	GO:0002674	negative regulation of acute inflammatory response
Biological Process	GO:0016525	negative regulation of angiogenesis
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration
Biological Process	GO:0030308	negative regulation of cell growth
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:1900077	negative regulation of cellular response to insulin stimulus
Biological Process	GO:0010887	negative regulation of cholesterol storage
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process
Biological Process	GO:0001818	negative regulation of cytokine production
Biological Process	GO:0060965	negative regulation of gene silencing by miRNA
Biological Process	GO:0050728	negative regulation of inflammatory response
Biological Process	GO:0060336	negative regulation of interferon-gamma-mediated signaling pathway
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation
Biological Process	GO:1903979	negative regulation of microglial cell activation
Biological Process	GO:0150079	negative regulation of neuroinflammatory response
Biological Process	GO:2000230	negative regulation of pancreatic stellate cell proliferation
Biological Process	GO:0090278	negative regulation of peptide hormone secretion
Biological Process	GO:0010871	negative regulation of receptor biosynthetic process
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation
Biological Process	GO:0051974	negative regulation of telomerase activity
Biological Process	GO:0045892	negative regulation of transcription, DNA-templated
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation
Biological Process	GO:1905563	negative regulation of vascular endothelial cell proliferation
Biological Process	GO:0035357	peroxisome proliferator activated receptor signaling pathway
Biological Process	GO:0001890	placenta development
Biological Process	GO:0043065	positive regulation of apoptotic process
Biological Process	GO:0043388	positive regulation of DNA binding
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity
Biological Process	GO:0045600	positive regulation of fat cell differentiation
Biological Process	GO:0045923	positive regulation of fatty acid metabolic process
Biological Process	GO:0046321	positive regulation of fatty acid oxidation
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation
Biological Process	GO:0060100	positive regulation of phagocytosis, engulfment
Biological Process	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
Biological Process	GO:0045893	positive regulation of transcription, DNA-templated
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process
Biological Process	GO:0008217	regulation of blood pressure
Biological Process	GO:0042752	regulation of circadian rhythm
Biological Process	GO:0045598	regulation of fat cell differentiation
Biological Process	GO:0010468	regulation of gene expression
Biological Process	GO:0019216	regulation of lipid metabolic process
Biological Process	GO:0006355	regulation of transcription, DNA-templated
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0060850	regulation of transcription involved in cell fate commitment
Biological Process	GO:0002021	response to dietary excess
Biological Process	GO:0032094	response to food
Biological Process	GO:0009416	response to light stimulus
Biological Process	GO:0033993	response to lipid
Biological Process	GO:0048384	retinoic acid receptor signaling pathway
Biological Process	GO:0048511	rhythmic process
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0050872	white fat cell differentiation
molecular function	GO:0033613	activating transcription factor binding
molecular function	GO:0051393	alpha-actinin binding
molecular function	GO:0050544	arachidonic acid binding
molecular function	GO:0003682	chromatin binding
molecular function	GO:0003677	DNA binding
molecular function	GO:0050692	DNA binding domain binding
molecular function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific
molecular function	GO:0003700	DNA-binding transcription factor activity
molecular function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
molecular function	GO:0003690	double-stranded DNA binding
molecular function	GO:0008144	drug binding
molecular function	GO:0070888	E-box binding
molecular function	GO:0019899	enzyme binding
molecular function	GO:0030331	estrogen receptor binding
molecular function	GO:0042802	identical protein binding
molecular function	GO:0050693	LBD domain binding
molecular function	GO:0004879	nuclear receptor activity
molecular function	GO:0030374	nuclear receptor transcription coactivator activity
molecular function	GO:0042277	peptide binding
molecular function	GO:1990841	promoter-specific chromatin binding
molecular function	GO:0008022	protein C-terminus binding
molecular function	GO:0019903	protein phosphatase binding
molecular function	GO:0043621	protein self-association
molecular function	GO:0046965	retinoid X receptor binding
molecular function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
molecular function	GO:0001103	RNA polymerase II repressing transcription factor binding
molecular function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
molecular function	GO:0038023	signaling receptor activity
molecular function	GO:0008134	transcription factor binding
molecular function	GO:0000976	transcription regulatory region sequence-specific DNA binding
molecular function	GO:0050699	WW domain binding
molecular function	GO:0008270	zinc ion binding
cellular component	GO:0005737	cytoplasm
cellular component	GO:0005829	cytosol
cellular component	GO:0043231	intracellular membrane-bounded organelle
cellular component	GO:0005654	nucleoplasm
cellular component	GO:0005634	nucleus
cellular component	GO:0048471	perinuclear region of cytoplasm
cellular component	GO:0032991	protein-containing complex
cellular component	GO:0090575	RNA polymerase II transcription regulator complex

Reactome

Pathway Id	Pathway Name

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0000340	Kaempferol		286.24
BXGC0000894	2-Methylthioribosyl-trans-zeatin		323.8
BXGC0000964	6-Methylscutellarein		300.26
BXGC0001778	Scutellarein		286.24
BXGC0001837	Quercetin 3-rutinoside		610.52
BXGC0002045	Acerosin		360.31
BXGC0002071	Apigenin		270.24
BXGC0005683	Quercetin		302.24
BXGC0005915	Formononetin		268.27
BXGC0006635	Luteolin		286.24
BXGC0008753	Isoquercitrin		464.38
BXGC0008824	Astragalin		448.38
BXGC0013013	6-methoxy-4',5-dihydroxyflavone-7-O-glucoside		462.12
BXGC0018425	(+)-Lichesterinic acid		324.23
BXGC0019649	Tadehaginoside		434.12
BXGC0021987	Scoparic Acid A		440.26
BXGC0022324	Quercetin 5-glucoside		464.1
BXGC0026855	Pectolinarin		622.19
BXGC0035226	Betulinic Acid		456.36
BXGC0039472	Narcissin		624.17
BXGC0045734	n.a		326.12

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}