Showing entry for Scutellarein


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0001778
Compound NameScutellarein
Structure
FormulaC15H10O6
InchiKeyJVXZRQGOGOXCEC-UHFFFAOYSA-N
SMILESOC1=CC=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C(O)=C2O
InchiInChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H
IUPAC5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Molecular Weight286.24
Pubchem Id5281697
Chembl IdCHEMBL55415
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 23411
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT006255 Alpha-amylase 1 reviewed AMY1A - 9640 - -
reviewed BXGT019667 Aurora kinase B reviewed Kinase AURKB - 3850 - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - >1.00e+5 - -
reviewed BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed Pparg - - - 16400
reviewed BXGT010872 Succinate-semialdehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH5A1 - 7200000 - -
reviewed BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed UGT1A1 41300 - - -
reviewed BXGT009967 Acetylcholinesterase reviewed Ache - >500000 - -
reviewed BXGT011911 Xanthine dehydrogenase/oxidase reviewed XDH - 12600 - -
reviewed BXGT022265 Sialidase-2 reviewed Enzyme NEU2 - 55000 - -
reviewed BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 1640 - - -
reviewed BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 220 - - -
reviewed BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 - >10000 - -
CHEMBL CHEMBL55415
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition '=' 62 %
Q16445 BXGT013629 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed Ion channel GABRA6 Ki '=' 12022 nM
P31644 BXGT009557 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed Ion channel GABRA5 Ki '=' 12022 nM
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed Ion channel GABRA2 Ki '=' 12022 nM
P78334 BXGT011834 Gamma-aminobutyric acid receptor subunit epsilon reviewed Ion channel GABRE Ki '=' 12022 nM
P18505 BXGT008409 Gamma-aminobutyric acid receptor subunit beta-1 reviewed Ion channel GABRB1 Ki '=' 12022 nM
Q8N1C3 BXGT018498 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed Ion channel GABRG1 Ki '=' 12022 nM
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta reviewed Ion channel GABRD Ki '=' 12022 nM
O00591 BXGT003939 Gamma-aminobutyric acid receptor subunit pi reviewed Ion channel GABRP Ki '=' 12022 nM
P34903 BXGT009769 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed Ion channel GABRA3 Ki '=' 12022 nM
Q9UN88 BXGT021783 Gamma-aminobutyric acid receptor subunit theta reviewed Ion channel GABRQ Ki '=' 12022 nM
Q99928 BXGT019975 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed Ion channel GABRG3 Ki '=' 12022 nM
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed Ion channel GABRA4 Ki '=' 12022 nM
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 reviewed Ion channel GABRB3 Ki '=' 12022 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 Ki '=' 12022 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 Ki '=' 12022 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 Ki '=' 12022 nM
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Vmax '=' 1 nmol/min/mg
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Vmax '=' 0 nmol/min/mg
P03468 BXGT006079 Neuraminidase reviewed - NA IC50 '=' 14 ug.mL-1
Q03114 BXGT012692 Cyclin-dependent-like kinase 5 reviewed - Cdk5 EC50 - - -
P04745 BXGT006255 Alpha-amylase 1 reviewed - AMY1A Inhibition '=' 98 %
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 IC50 '>' 10000 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Km '=' 2740 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax '=' 5 nmol/min/mg
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Km '=' 27000 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Vmax '=' 1 nmol/min/mg
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Km '=' 7340 nM
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Km '=' 5490 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Km '=' 5680 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Vmax '=' 0 nmol/min/mg
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Vmax/Km '=' 843 microL/min/mg
P43250 BXGT010372 G protein-coupled receptor kinase 6 reviewed Kinase GRK6 IC50 '=' 6610 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH IC50 '=' 12600 nM
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 Activity '=' 12 %
Q9Y3R4 BXGT022265 Sialidase-2 reviewed Enzyme NEU2 IC50 '=' 55000 nM
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS Inhibition - - -
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 67 %
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Ki '=' 41300 nM
P03468 BXGT006079 Neuraminidase reviewed - NA logIC50 '=' 1 -
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Activity '=' 92 %
P37238 BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed - Pparg Emax '=' 3 -
P19224 BXGT008468 UDP-glucuronosyltransferase 1-6 reviewed - UGT1A6 Vmax/Km '=' 62 microL/min/mg
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Vmax/Km '=' 153 microL/min/mg
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Vmax '=' 4 nmol/min/mg
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Vmax '=' 0 nmol/min/mg
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Ki '=' 220 nM
P04745 BXGT006255 Alpha-amylase 1 reviewed - AMY1A IC50 '=' 9640 nM
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 Ki '=' 1640 nM
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS Inhibition '=' 90 %
P51649 BXGT010872 Succinate-semialdehyde dehydrogenase, mitochondrial reviewed Enzyme ALDH5A1 IC50 '=' 7200000 nM
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Km '=' 19000 nM
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM IC50 '=' 12500 nM
Q86831 BXGT017584 Polyprotein II unreviewed - Inhibition '=' 99 %
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Vmax/Km '=' 13 microL/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax/Km '=' 1269 microL/min/mg
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Vmax/Km '=' 55 microL/min/mg
Q9HAW9 BXGT020510 UDP-glucuronosyltransferase 1-8 reviewed - UGT1A8 Vmax/Km '=' 35 microL/min/mg
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Vmax/Km '=' 23 microL/min/mg
O60656 BXGT004889 UDP-glucuronosyltransferase 1-9 reviewed - UGT1A9 Km '=' 10900 nM
O75874 BXGT005157 Isocitrate dehydrogenase [NADP] cytoplasmic reviewed - IDH1 Activity '=' 89 %
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Vmax/Km '=' 7 microL/min/mg
P37238 BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed - Pparg EC50 '=' 16400 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax/Km '=' 48 microL/min/mg
Q9HAW7 BXGT020508 UDP-glucuronosyltransferase 1-7 reviewed - UGT1A7 Km '=' 33300 nM
P37136 BXGT009967 Acetylcholinesterase reviewed - Ache IC50 '>' 500000 nM
Q13332 BXGT013342 Receptor-type tyrosine-protein phosphatase S reviewed Enzyme PTPRS IC50 '=' 600 nM
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Km '=' 11500 nM
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Vmax/Km '=' 243 microL/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Vmax '=' 0 nmol/min/mg
P16662 BXGT008253 UDP-glucuronosyltransferase 2B7 reviewed - UGT2B7 Vmax '=' 0 nmol/min/mg
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Km '=' 4490 nM
P35503 BXGT009840 UDP-glucuronosyltransferase 1-3 reviewed - UGT1A3 Vmax '=' 1 nmol/min/mg
P18433 BXGT008403 Receptor-type tyrosine-protein phosphatase alpha reviewed Enzyme PTPRA Inhibition '<' 0 %
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM IC50 '=' 100000 nM
P22309 BXGT008753 UDP-glucuronosyltransferase 1-1 reviewed - UGT1A1 Km '=' 6050 nM
Q9HAW8 BXGT020509 UDP-glucuronosyltransferase 1-10 reviewed - UGT1A10 Vmax '=' 0 nmol/min/mg
Q15118 BXGT013540 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial reviewed Kinase PDK1 Inhibition '=' 9 %
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM Inhibition - - -
P29350 BXGT009335 Tyrosine-protein phosphatase non-receptor type 6 reviewed - PTPN6 Inhibition '=' 93 %
V9HWB9 BXGT026149 L-lactate dehydrogenase unreviewed - HEL-S-133P Inhibition - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00057 Sweet orange Citrus sinensis Fruits
BXGF00102 Mexican oregano Lippia graveolens Herbs and Spices
BXGF00168 Winter savory Satureja montana Herbs and Spices
BXGF00269 Asian pear Pyrus pyrifolia Fruits
BXGF00888 Echinocereus blanckii Echinocereus blanckii Others
BXGF01004 Rabdosia weisiensis Rabdosia weisiensis Others
BXGF01084 Duranta erecta Duranta erecta Medicinal Plant
BXGF01139 Alluaudia ascendens Alluaudia ascendens Others
BXGF01555 Scutellaria amoena Scutellaria amoena Medicinal Plant
BXGF01681 Barleria acanthoides Barleria acanthoides Medicinal Plant
BXGF02167 Scutellaria barbata Scutellaria barbata Medicinal Plant
BXGF02336 Marrubium globosum Marrubium globosum Others
BXGF02475 Uncaria sessilifructus Uncaria sessilifructus Medicinal Plant
BXGF02767 Aloe nobilis Aloe nobilis Others
BXGF02783 Hexalobus crispiflorus Hexalobus crispiflorus Medicinal Plant
BXGF02837 Tsuga heterophylla Tsuga heterophylla Medicinal Plant
BXGF02899 Euodia lunu-ankenda Euodia lunu-ankenda Others
BXGF03047 Scutellaria indica Scutellaria indica Medicinal Plant
BXGF03050 Dracocephalum tanguticum Dracocephalum tanguticum Others
BXGF03052 Eclipta prostrata Eclipta prostrata Medicinal Plant
BXGF03547 Physostigma venenosum Physostigma venenosum Medicinal Plant
BXGF04121 Cordia elaeagnoides Cordia elaeagnoides Others
BXGF04691 Oroxylum indicum Oroxylum indicum Medicinal Plant
BXGF04750 Scutellaria baicalensis Scutellaria baicalensis Medicinal Plant
BXGF05204 Erigeron breviscapus Erigeron breviscapus Medicinal Plant
BXGF05240 Centaurea collina Centaurea collina Others
BXGF05282 Achillea serbica Achillea serbica Others
BXGF05461 Euonymus nanus Euonymus nanus Others
BXGF05536 Millingtonia hortensis Millingtonia hortensis Medicinal Plant
BXGF05703 Sinapis nigra Sinapis nigra Medicinal Plant
BXGF05856 Isodon leucophyllus Isodon leucophyllus Medicinal Plant
BXGF05864 Ptelea viscosa Ptelea viscosa Others
BXGF06070 Perilla frutescens Perilla frutescens Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease