Showing entry for 6-Methylscutellarein


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0000964
Compound Name6-Methylscutellarein
Structure
FormulaC16H12O6
InchiKeyIHFBPDAQLQOCBX-UHFFFAOYSA-N
SMILESCOC1=C(O)C2=C(OC(=CC2=O)C2=CC=C(O)C=C2)C=C1O
InchiInChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
IUPAC5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one
Molecular Weight300.26
Pubchem Id5281628
Chembl IdCHEMBL293776
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB HUL
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed PIM1 Kinase - 2710 - -
Binding DB 50049395
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 - 18600 - -
reviewed BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 - 34800 - -
reviewed BXGT010897 Nuclear receptor subfamily 0 group B member 1 reviewed Nuclear receptor NR0B1 - >833.72 - -
reviewed BXGT013335 Steroidogenic factor 1 reviewed Nuclear receptor NR5A1 - >67536 - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 1622 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 7586 - - -
reviewed BXGT009437 Adenosine receptor A2a reviewed Adora2a 6480 - - -
reviewed BXGT009016 Adenosine receptor A1 reviewed Adora1 1610 - - -
reviewed BXGT012692 Cyclin-dependent-like kinase 5 reviewed Cdk5 - - - 19100
reviewed BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed Pparg - - - 7300
reviewed BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 - 2710 - -
CHEMBL CHEMBL293776
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16445 BXGT013629 Gamma-aminobutyric acid receptor subunit alpha-6 reviewed Ion channel GABRA6 Ki '=' 1000 nM
P31644 BXGT009557 Gamma-aminobutyric acid receptor subunit alpha-5 reviewed Ion channel GABRA5 Ki '=' 1000 nM
P47869 BXGT010590 Gamma-aminobutyric acid receptor subunit alpha-2 reviewed Ion channel GABRA2 Ki '=' 1000 nM
P78334 BXGT011834 Gamma-aminobutyric acid receptor subunit epsilon reviewed Ion channel GABRE Ki '=' 1000 nM
P18505 BXGT008409 Gamma-aminobutyric acid receptor subunit beta-1 reviewed Ion channel GABRB1 Ki '=' 1000 nM
Q8N1C3 BXGT018498 Gamma-aminobutyric acid receptor subunit gamma-1 reviewed Ion channel GABRG1 Ki '=' 1000 nM
O14764 BXGT004094 Gamma-aminobutyric acid receptor subunit delta reviewed Ion channel GABRD Ki '=' 1000 nM
O00591 BXGT003939 Gamma-aminobutyric acid receptor subunit pi reviewed Ion channel GABRP Ki '=' 1000 nM
P34903 BXGT009769 Gamma-aminobutyric acid receptor subunit alpha-3 reviewed Ion channel GABRA3 Ki '=' 1000 nM
Q9UN88 BXGT021783 Gamma-aminobutyric acid receptor subunit theta reviewed Ion channel GABRQ Ki '=' 1000 nM
Q99928 BXGT019975 Gamma-aminobutyric acid receptor subunit gamma-3 reviewed Ion channel GABRG3 Ki '=' 1000 nM
P48169 BXGT010622 Gamma-aminobutyric acid receptor subunit alpha-4 reviewed Ion channel GABRA4 Ki '=' 1000 nM
P28472 BXGT009260 Gamma-aminobutyric acid receptor subunit beta-3 reviewed Ion channel GABRB3 Ki '=' 1000 nM
P18507 BXGT008411 Gamma-aminobutyric acid receptor subunit gamma-2 reviewed Ion channel GABRG2 Ki '=' 1000 nM
P47870 BXGT010591 Gamma-aminobutyric acid receptor subunit beta-2 reviewed Ion channel GABRB2 Ki '=' 1000 nM
P14867 BXGT008061 Gamma-aminobutyric acid receptor subunit alpha-1 reviewed Ion channel GABRA1 Ki '=' 1000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 70794 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 5802 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 26000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 22387 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 33200 nM
P51843 BXGT010897 Nuclear receptor subfamily 0 group B member 1 reviewed Nuclear receptor NR0B1 IC50 '>' 833 nM
P03468 BXGT006079 Neuraminidase reviewed - NA logIC50 '=' 1 -
P04062 BXGT006140 Lysosomal acid glucosylceramidase reviewed - GBA Potency - 25118 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 9196 nM
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a pKi(uM) '=' 0 -
Q03114 BXGT012692 Cyclin-dependent-like kinase 5 reviewed - Cdk5 EC50 '=' 19100 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency - 39810 nM
P55789 BXGT011126 FAD-linked sulfhydryl oxidase ALR reviewed Enzyme GFER AC50 '=' 572 nM
P51450 BXGT010847 Nuclear receptor ROR-gamma reviewed - Rorc Potency '=' 35481 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 19952 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 4466 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Q86831 BXGT017584 Polyprotein II unreviewed - Inhibition '=' 23 %
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 33587 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 Ki '=' 1610 nM
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 7079 nM
Q194T2 BXGT013743 Non-structural protein 1 unreviewed - NS1 Potency '=' 11220 nM
P25099 BXGT009016 Adenosine receptor A1 reviewed - Adora1 pKi(uM) '=' 0 -
P30543 BXGT009437 Adenosine receptor A2a reviewed - Adora2a Ki '=' 6480 nM
P37238 BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed - Pparg EC50 '=' 7300 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Displacement '=' 63 %
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 31622 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 31622 nM
P03468 BXGT006079 Neuraminidase reviewed - NA IC50 '=' 13 ug.mL-1
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 89125 nM
Q13315 BXGT013339 Serine-protein kinase ATM reviewed Kinase ATM Potency '=' 25118 nM
O94782 BXGT005332 Ubiquitin carboxyl-terminal hydrolase 1 reviewed Enzyme USP1 Potency - 6309 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 3162 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 46300 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 19952 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 pKi(uM) - - -
O97467 BXGT005437 Hexose transporter 1 unreviewed - ht1 Inhibition '=' 1 %
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 849 nM
P37238 BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed - Pparg Emax '=' 11 -
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 reviewed Transporter SLC2A1 Inhibition '=' 1 %
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 Inhibition '=' 86 %
O61059 BXGT004913 Glucose transporter unreviewed - LmGT2 Inhibition '=' 3 %
P22411 BXGT008763 Dipeptidyl peptidase 4 reviewed - DPP4 IC50 '=' 490 nM
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 IC50 '=' 2710 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00010 Lemon verbena Aloysia triphylla Herbs and Spices
BXGF00019 Tarragon Artemisia dracunculus Herbs and Spices
BXGF00085 Soy bean Glycine max Soy
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00102 Mexican oregano Lippia graveolens Herbs and Spices
BXGF00159 Rosemary Rosmarinus officinalis Herbs and Spices
BXGF00165 Common sage Salvia officinalis Herbs and Spices
BXGF00183 Common thyme Thymus vulgaris Herbs and Spices
BXGF00242 Italian oregano Origanum X majoricum Herbs and Spices
BXGF00269 Asian pear Pyrus pyrifolia Fruits
BXGF00402 Opium poppy Papaver somniferum Herbs and Spices
BXGF00422 Mamey sapote Pouteria sapota Fruits
BXGF00888 Echinocereus blanckii Echinocereus blanckii Others
BXGF01004 Rabdosia weisiensis Rabdosia weisiensis Others
BXGF01115 Eriodictyon californicum Eriodictyon californicum Medicinal Plant
BXGF01139 Alluaudia ascendens Alluaudia ascendens Others
BXGF01178 Ledebouria floribunda Ledebouria floribunda Others
BXGF01215 Cirsium setosum Cirsium setosum Medicinal Plant
BXGF01216 Drosera spatulata Drosera spatulata Others
BXGF01239 Anthemis pseudocotula Anthemis pseudocotula Others
BXGF01261 Ambrosia hispida Ambrosia hispida Medicinal Plant
BXGF01296 Triticum estivum Triticum estivum Others
BXGF01467 Torreya fargesii var. yunnanensis Torreya fargesii var. yunnanensis Medicinal Plant
BXGF01629 Satureja odora Satureja odora Medicinal Plant
BXGF01681 Barleria acanthoides Barleria acanthoides Medicinal Plant
BXGF01744 Xylosma longifolia Xylosma longifolia Medicinal Plant
BXGF01748 Dacryodes normandii Dacryodes normandii Others
BXGF01750 Leucaena leucocephala Leucaena leucocephala Medicinal Plant
BXGF01790 Riccia fluitans Riccia fluitans Others
BXGF01826 Hypericum hirsutum Hypericum hirsutum Medicinal Plant
BXGF01864 Baccharis trimera Baccharis trimera Medicinal Plant
BXGF01952 Senecio microglossus Senecio microglossus Others
BXGF02118 Polygonatum prattii Polygonatum prattii Medicinal Plant
BXGF02129 Hunteria zeylanica Hunteria zeylanica Medicinal Plant
BXGF02167 Scutellaria barbata Scutellaria barbata Medicinal Plant
BXGF02175 Micromeria japonica Micromeria japonica Others
BXGF02245 Peperomia villipetiola Peperomia villipetiola Others
BXGF02272 Muraltia heisteria Muraltia heisteria Medicinal Plant
BXGF02336 Marrubium globosum Marrubium globosum Others
BXGF02406 Selaginella apoda Selaginella apoda Others
BXGF02475 Uncaria sessilifructus Uncaria sessilifructus Medicinal Plant
BXGF02526 Santalum album Santalum album Medicinal Plant
BXGF02568 Scutellaria przewalskii Scutellaria przewalskii Others
BXGF02569 Ibervillea sonorae Ibervillea sonorae Medicinal Plant
BXGF02731 Saussurea involucrata Saussurea involucrata Medicinal Plant
BXGF02767 Aloe nobilis Aloe nobilis Others
BXGF02783 Hexalobus crispiflorus Hexalobus crispiflorus Medicinal Plant
BXGF02837 Tsuga heterophylla Tsuga heterophylla Medicinal Plant
BXGF02899 Euodia lunu-ankenda Euodia lunu-ankenda Others
BXGF02909 Eupatorium leucolepis Eupatorium leucolepis Others
BXGF02917 Albizia amara Albizia amara Medicinal Plant
BXGF03014 Cirsium japonicum Cirsium japonicum Medicinal Plant
BXGF03175 Pseudognaphalium affine Pseudognaphalium affine Others
BXGF03284 Senecio tricephalus Senecio tricephalus Others
BXGF03341 Lycopus lucidus Lycopus lucidus Medicinal Plant
BXGF03365 Veronicastrum virginicum Veronicastrum virginicum Others
BXGF03429 Digitalis lanata Digitalis lanata Medicinal Plant
BXGF03469 Vernonia pachyclada Vernonia pachyclada Others
BXGF03547 Physostigma venenosum Physostigma venenosum Medicinal Plant
BXGF04121 Cordia elaeagnoides Cordia elaeagnoides Others
BXGF04192 Helenium autumnale Helenium autumnale Medicinal Plant
BXGF04611 Artemisia argyi Artemisia argyi Medicinal Plant
BXGF04705 Abrus precatorius Abrus precatorius Medicinal Plant
BXGF04977 Papaver sommiferum Papaver sommiferum Medicinal Plant
BXGF05065 Kniphofia pumila Kniphofia pumila Others
BXGF05240 Centaurea collina Centaurea collina Others
BXGF05282 Achillea serbica Achillea serbica Others
BXGF05461 Euonymus nanus Euonymus nanus Others
BXGF05536 Millingtonia hortensis Millingtonia hortensis Medicinal Plant
BXGF05639 Mulguraea tridens Mulguraea tridens Others
BXGF05683 Vaccinium ashei Vaccinium ashei Medicinal Plant
BXGF05700 Crepis pygmaea Crepis pygmaea Others
BXGF05703 Sinapis nigra Sinapis nigra Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF05856 Isodon leucophyllus Isodon leucophyllus Medicinal Plant
BXGF05864 Ptelea viscosa Ptelea viscosa Others
BXGF05867 Asphodelus tenuifolius Asphodelus tenuifolius Medicinal Plant
BXGF05883 Pachyrhizus tuberosus Pachyrhizus tuberosus Medicinal Plant
BXGF06108 Centipeda minima Centipeda minima Medicinal Plant
BXGF06113 Plantago depressa Plantago depressa Medicinal Plant
BXGF06202 Solidago spathulata Solidago spathulata Medicinal Plant
BXGF06218 Siphocampylus foliosus Siphocampylus foliosus Others
BXGF06233 Myrtopsis novae-caledoniae Myrtopsis novae-caledoniae Others
BXGF06256 Delphinium hybr Delphinium hybr Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease