Showing entry for Formononetin



                             
General Compound Information
BXGC IdBXGC0005915
Compound NameFormononetin
Structure
FormulaC16H12O4
InchiKeyHKQYGTCOTHHOMP-UHFFFAOYSA-N
SMILESCOC1=CC=C(C=C1)C1=COC2=C(C=CC(O)=C2)C1=O
InchiInChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
IUPAC7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
Molecular Weight268.27
Pubchem Id5280378
Chembl IdCHEMBL242341
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50021398
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT011315 Interleukin-2 reviewed IL2 - - 5470 -
CHEMBL CHEMBL242341
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 16360 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 5040 nM
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 35481 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 3040 nM
O35235 BXGT004518 Tumor necrosis factor ligand superfamily member 11 reviewed - Tnfsf11 Inhibition - - -
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 39810 nM
P80457 BXGT011911 Xanthine dehydrogenase/oxidase reviewed - XDH Inhibition '=' 17 %
P11021 BXGT007644 Endoplasmic reticulum chaperone BiP reviewed - HSPA5 Potency - 12589 nM
P00352 BXGT005510 Retinal dehydrogenase 1 reviewed Enzyme ALDH1A1 Potency '=' 39810 nM
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 IC50 '<' 100000 nM
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 15848 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '>' 100000 nM
P15917 BXGT008169 Lethal factor reviewed - lef Potency '=' 12589 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA FC '=' 7 -
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD FC '=' 7 -
P08684 BXGT006812 Cytochrome P450 3A4 reviewed Enzyme CYP3A4 Potency '=' 15848 nM
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha reviewed Nuclear receptor PPARA FC '=' 7 -
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 1584 nM
P31639 BXGT009556 Sodium/glucose cotransporter 2 reviewed Transporter SLC5A2 Inhibition '=' 75 %
Q99714 BXGT019954 3-hydroxyacyl-CoA dehydrogenase type-2 reviewed Enzyme HSD17B10 Potency '=' 31622 nM
Q03164 BXGT012700 Histone-lysine N-methyltransferase 2A reviewed - KMT2A Potency '=' 39810 nM
O00255 BXGT003903 Menin reviewed - MEN1 Potency '=' 39810 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 11220 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 31622 nM
Q9Y6L6 BXGT022334 Solute carrier organic anion transporter family member 1B1 reviewed Transporter SLCO1B1 Inhibition '=' 169 %
P10635 BXGT007595 Cytochrome P450 2D6 reviewed - CYP2D6 Potency '=' 10000 nM
P37238 BXGT009974 Peroxisome proliferator-activated receptor gamma reviewed - Pparg Activity - - -
P13866 BXGT007963 Sodium/glucose cotransporter 1 reviewed Transporter SLC5A1 Inhibition '<' 25 %
P04637 BXGT006243 Cellular tumor antigen p53 reviewed Transcription factor TP53 Potency '=' 3981 nM
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 7307 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 7307 nM
P62826 BXGT011463 GTP-binding nuclear protein Ran reviewed Enzyme modulator RAN Potency - 7307 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 2238 nM
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG FC '=' 12 -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG FC '=' 4 -
P15428 BXGT008121 15-hydroxyprostaglandin dehydrogenase [NAD(+)] reviewed - HPGD Potency '=' 25118 nM
B4URF0 BXGT002146 Neuraminidase unreviewed - NA Ratio IC50 '=' 10 -
P04798 BXGT006265 Cytochrome P450 1A1 reviewed Enzyme CYP1A1 Inhibition '=' 10 %
P60568 BXGT011315 Interleukin-2 reviewed - IL2 Kd '=' 5470 nM
O42275 BXGT004559 Acetylcholinesterase reviewed - ache Inhibition '=' 1 %
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Inhibition - - -
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Activity '=' 57 %
P33261 BXGT009707 Cytochrome P450 2C19 reviewed - CYP2C19 Potency '=' 7943 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 5011 nM
P11712 BXGT007738 Cytochrome P450 2C9 reviewed - CYP2C9 Potency '=' 10 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 28183 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 FC '=' 2 -
P33527 BXGT009728 Multidrug resistance-associated protein 1 reviewed Transporter ABCC1 Activity - - -
P81908 BXGT011959 Cholinesterase reviewed - BCHE Inhibition '=' 0 %
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA FC '=' 1 -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 FC '=' 1 -
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 FC '=' 1 -
Q04207 BXGT012755 Transcription factor p65 reviewed - Rela Inhibition - - -
P31750 BXGT009575 RAC-alpha serine/threonine-protein kinase reviewed - Akt1 Inhibition - - -
P14679 BXGT008039 Tyrosinase reviewed Enzyme TYR Inhibition '=' 4 %
Q9NPD5 BXGT021151 Solute carrier organic anion transporter family member 1B3 reviewed Transporter SLCO1B3 Inhibition '=' 114 %
Q9Z1B7 BXGT022403 Mitogen-activated protein kinase 13 reviewed - Mapk13 Inhibition - - -
Q9WUI1 BXGT021940 Mitogen-activated protein kinase 11 reviewed - Mapk11 Inhibition - - -
O08911 BXGT004043 Mitogen-activated protein kinase 12 reviewed - Mapk12 Inhibition - - -
P47811 BXGT010587 Mitogen-activated protein kinase 14 reviewed - Mapk14 Inhibition - - -
Q03181 BXGT012701 Peroxisome proliferator-activated receptor delta reviewed Nuclear receptor PPARD FC '=' 12 -
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Ki '=' 3700 nM
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 31622 nM
Q04206 BXGT012754 Transcription factor p65 reviewed Transcription factor RELA Inhibition - - -
P19838 BXGT008526 Nuclear factor NF-kappa-B p105 subunit reviewed Transcription factor NFKB1 Inhibition - - -
Q00653 BXGT012541 Nuclear factor NF-kappa-B p100 subunit reviewed Transcription factor NFKB2 Inhibition - - -
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma reviewed Nuclear receptor PPARG Activity - - -
P23204 BXGT008836 Peroxisome proliferator-activated receptor alpha reviewed - Ppara Activity - - -
P14916 BXGT008066 Urease subunit alpha reviewed - ureA IC50 '=' 2003000 nM
P69996 BXGT011656 Urease subunit beta reviewed - ureB IC50 '=' 2003000 nM
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition '=' 33 %
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 reviewed - PTPN1 Inhibition '=' 9 %
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Inhibition '>' 90 %
B4URF0 BXGT002146 Neuraminidase unreviewed - NA IC50 '=' 1370 nM
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 FC '=' 2 -
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Potency - 112201 nM
P06401 BXGT006436 Progesterone receptor reviewed Nuclear receptor PGR Activity - - -
Q16678 BXGT013656 Cytochrome P450 1B1 reviewed Enzyme CYP1B1 Inhibition '=' -1 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00022 Oat Avena sativa Cereals and cereal products
BXGF00038 Tea Camellia sinensis Teas
BXGF00047 Chickpea Cicer arietinum Pulses
BXGF00085 Soy bean Glycine max Soy
BXGF00086 Sunflower Helianthus annuus Herbs and Spices
BXGF00141 Common pea Pisum sativum Pulses
BXGF00186 Fenugreek Trigonella foenum-graecum Herbs and Spices
BXGF00200 Mung bean Vigna radiata Pulses
BXGF00251 Other soy product Soy
BXGF00264 Alfalfa Medicago sativa Herbs and Spices
BXGF00380 White mustard Sinapis alba Herbs and Spices
BXGF00649 Soy sauce Soy
BXGF00650 Miso Soy
BXGF00651 Tofu Soy
BXGF00691 Soy milk Soy
BXGF00722 Soy yogurt Soy
BXGF00731 Ucuhuba Virola surinamensis Herbs and Spices
BXGF00818 Herbs and Spices Herbs and Spices
BXGF00819 Pulses Pulses
BXGF00857 Mitracarpus scaber Mitracarpus scaber Others
BXGF00861 Abies pinsapo var. marocana Abies pinsapo var. marocana Others
BXGF00957 Allagopappus viscosissimus Allagopappus viscosissimus Others
BXGF01168 Erysimum leptophyllum Erysimum leptophyllum Others
BXGF01173 Astragalus spinosus Astragalus spinosus Others
BXGF01235 Swertia decussata Swertia decussata Medicinal Plant
BXGF01269 Peltogyne pubescens Peltogyne pubescens Others
BXGF01295 Chondrodendron tomentosum Chondrodendron tomentosum Medicinal Plant
BXGF01314 Thalictrum flavum Thalictrum flavum Medicinal Plant
BXGF01321 Ranunculus peltatus Ranunculus peltatus Others
BXGF01324 Albizia julibrissin Albizia julibrissin Medicinal Plant
BXGF01325 Murraya exotica Murraya exotica Medicinal Plant
BXGF01349 Hydrangea serrata Hydrangea serrata Medicinal Plant
BXGF01354 Haplophyllum obtusifolium Haplophyllum obtusifolium Others
BXGF01437 Lunularia cruciata Lunularia cruciata Others
BXGF01508 Onobrychis cyri Onobrychis cyri Others
BXGF01563 Echinops transiliensis Echinops transiliensis Others
BXGF01621 Syzygium polycephaloides Syzygium polycephaloides Human Edible Plant
BXGF01632 Euphrasia genargentea Euphrasia genargentea Others
BXGF01762 Persea kusanoi Persea kusanoi Others
BXGF01768 Dalbergia parviflora Dalbergia parviflora Medicinal Plant
BXGF01803 Acnistus breviflorus Acnistus breviflorus Others
BXGF01851 Oxalis purpurea Oxalis purpurea Human Edible Plant
BXGF01892 Xanthorhiza simplicissima Xanthorhiza simplicissima Medicinal Plant
BXGF01914 Lantana montevidensis Lantana montevidensis Human Edible Plant
BXGF01996 Senecio suaveolens Senecio suaveolens Others
BXGF02026 Olearia pimeleoides Olearia pimeleoides Others
BXGF02036 Glycyrrhiza pallidiflora Glycyrrhiza pallidiflora Medicinal Plant
BXGF02056 Muscari botryoides Muscari botryoides Medicinal Plant
BXGF02084 Dasycladus vermicularis Dasycladus vermicularis Others
BXGF02103 Astragalus mongholicus Astragalus mongholicus Medicinal Plant
BXGF02131 Glycyrrhiza Glycyrrhiza Medicinal Plant
BXGF02202 Piper regnellii Piper regnellii Medicinal Plant
BXGF02257 Teclea gerrardii Teclea gerrardii Medicinal Plant
BXGF02268 Ginkgo semen Ginkgo semen Others
BXGF02287 Gymnocalycium schickendantzii Gymnocalycium schickendantzii Others
BXGF02332 Salvia castanea Salvia castanea Medicinal Plant
BXGF02347 Glinus lotoides Glinus lotoides Medicinal Plant
BXGF02368 Amorpha fruticosa Amorpha fruticosa Medicinal Plant
BXGF02381 Glycyrrhiza inflata Glycyrrhiza inflata Medicinal Plant
BXGF02419 Albizia inundata Albizia inundata Medicinal Plant
BXGF02445 Onopordum acanthium Onopordum acanthium Medicinal Plant
BXGF02474 Sparganium stoloniferum Sparganium stoloniferum Medicinal Plant
BXGF02500 Pancratium sickenbergeri Pancratium sickenbergeri Others
BXGF02572 Tipuana tipu Tipuana tipu Others
BXGF02573 Centaurea maculosa Centaurea maculosa Others
BXGF02626 Dalbergia odorifera Dalbergia odorifera Medicinal Plant
BXGF02635 Ephedra sinica Ephedra sinica Medicinal Plant
BXGF02687 Papaver tatricum Papaver tatricum Others
BXGF02695 Plathymenia reticulata Plathymenia reticulata Others
BXGF02729 Asimina parviflora Asimina parviflora Medicinal Plant
BXGF02774 Pteridium esculentum Pteridium esculentum Medicinal Plant
BXGF02813 Esenbeckia leiocarpa Esenbeckia leiocarpa Others
BXGF02852 Sophora flavescens Sophora flavescens Medicinal Plant
BXGF02929 Hypericum styphelioides Hypericum styphelioides Others
BXGF02973 Vellozia nanuzae Vellozia nanuzae Others
BXGF02992 Baccharis neglecta Baccharis neglecta Others
BXGF03012 Atraphaxis spinosa Atraphaxis spinosa Medicinal Plant
BXGF03027 Embelia schimperi Embelia schimperi Medicinal Plant
BXGF03087 Epilobium hirsutum Epilobium hirsutum Medicinal Plant
BXGF03106 Lythrum salicaria Lythrum salicaria Medicinal Plant
BXGF03113 Simarouba glauca Simarouba glauca Medicinal Plant
BXGF03116 Dalbergia frutescens Dalbergia frutescens Others
BXGF03126 Erythrina melanacantha Erythrina melanacantha Medicinal Plant
BXGF03151 Monsonia senegalensis Monsonia senegalensis Human Edible Plant
BXGF03157 Clerodendrum bungei Clerodendrum bungei Medicinal Plant
BXGF03163 Wisteria brachybotrys Wisteria brachybotrys Human Edible Plant
BXGF03186 Lemaireocereus longispinus Lemaireocereus longispinus Others
BXGF03197 Eria anomala Eria anomala Others
BXGF03208 Embelia parviflora Embelia parviflora Medicinal Plant
BXGF03231 Dactylorhiza viridis Dactylorhiza viridis Others
BXGF03250 Euphorbia nematocypha Euphorbia nematocypha Medicinal Plant
BXGF03271 Pterolobium hexapetalum Pterolobium hexapetalum Medicinal Plant
BXGF03279 Abelia chinensis Abelia chinensis Unclassified
BXGF03297 Diospyros assimilis Diospyros assimilis Medicinal Plant
BXGF03310 Faramea salicifolia Faramea salicifolia Others
BXGF03397 Trifolium pratense Trifolium pratense Medicinal Plant
BXGF03500 Croton megistocarpus Croton megistocarpus Others
BXGF03564 Vernonia fagifolia Vernonia fagifolia Others
BXGF03570 Cordia leucocephala Cordia leucocephala Others
BXGF03605 Stellaria holostea Stellaria holostea Human Edible Plant
BXGF03731 Rosulabryum capillare Rosulabryum capillare Others
BXGF03774 Citrus rugulosa Citrus rugulosa Others
BXGF03813 Diplopterygium glaucum Diplopterygium glaucum Others
BXGF03901 Astragalus membranaceus Astragalus membranaceus Medicinal Plant
BXGF03908 Hedysarum multijugum maxim Hedysarum multijugum maxim Others
BXGF03919 Xanthium strumarium Xanthium strumarium Medicinal Plant
BXGF04060 Aglaia australiensis Aglaia australiensis Others
BXGF04062 Spatholobus suberectus Spatholobus suberectus Medicinal Plant
BXGF04150 Erycibe expansa Erycibe expansa Medicinal Plant
BXGF04263 Glycine soja Glycine soja Medicinal Plant
BXGF04274 Macadamia ternifolia Macadamia ternifolia Medicinal Plant
BXGF04296 Maytenus chuchuhuasha Maytenus chuchuhuasha Others
BXGF04301 Dorstenia dinklagei Dorstenia dinklagei Others
BXGF04328 Croton zehntneri Croton zehntneri Others
BXGF04382 Murraya paniculata Murraya paniculata Medicinal Plant
BXGF04458 Oxytropis falcata Oxytropis falcata Others
BXGF04584 Helichrysum tenuifolium Helichrysum tenuifolium Others
BXGF04772 Sapium haematospermum Sapium haematospermum Medicinal Plant
BXGF04842 Angelica acutiloba Angelica acutiloba Medicinal Plant
BXGF04872 Glycyrrhiza glabra Glycyrrhiza glabra Medicinal Plant
BXGF04881 Fallopia multiflora Fallopia multiflora Medicinal Plant
BXGF04943 Pueraria lobata Pueraria lobata Medicinal Plant
BXGF05009 Solanum lanceolatum Solanum lanceolatum Medicinal Plant
BXGF05010 Morella rubra Morella rubra 0
BXGF05041 Desmodium styracifolium Desmodium styracifolium Medicinal Plant
BXGF05050 Diplacus longiflorus Diplacus longiflorus Others
BXGF05067 Bryonia alba Bryonia alba Medicinal Plant
BXGF05129 Achillea pseudopectinata Achillea pseudopectinata Others
BXGF05141 Viburnum erubescens Viburnum erubescens Medicinal Plant
BXGF05241 Dalbergia assamica Dalbergia assamica Others
BXGF05258 Geranium sibiricum Geranium sibiricum Medicinal Plant
BXGF05293 Remirea maritima Remirea maritima Others
BXGF05301 Baphicacanthus cusia Baphicacanthus cusia Medicinal Plant
BXGF05303 Lagerstroemia indica Lagerstroemia indica Medicinal Plant
BXGF05328 Syzygium nervosum Syzygium nervosum Human Edible Plant
BXGF05364 Arnica mollis Arnica mollis Others
BXGF05366 Lepidosperma ustulatum Lepidosperma ustulatum Others
BXGF05371 Garrya elliptica Garrya elliptica Others
BXGF05446 Nassauvia cumingii Nassauvia cumingii Others
BXGF05498 Croton gratissimus Croton gratissimus Medicinal Plant
BXGF05526 Salvia miltiorrhiza Salvia miltiorrhiza Medicinal Plant
BXGF05559 Wikstroemia viridiflora Wikstroemia viridiflora Medicinal Plant
BXGF05584 Brassica carinata Brassica carinata Medicinal Plant
BXGF05678 Dunalia solanacea Dunalia solanacea Others
BXGF05708 Ononis spinosa Ononis spinosa Medicinal Plant
BXGF05722 Hedysarum polybotrys Hedysarum polybotrys Medicinal Plant
BXGF05725 Ranunculus asiaticus Ranunculus asiaticus Others
BXGF05736 Eurycoma harmandiana Eurycoma harmandiana Medicinal Plant
BXGF05761 Berberis floribunda Berberis floribunda Medicinal Plant
BXGF05790 Glycyrrhiza uralensis Glycyrrhiza uralensis Medicinal Plant
BXGF05820 Jamesoniella colorata Jamesoniella colorata Medicinal Plant
BXGF05840 Eucalyptus resinifera Eucalyptus resinifera Medicinal Plant
BXGF05875 Fumaria micrantha Fumaria micrantha Others
BXGF05878 Senecio isatideus Senecio isatideus Others
BXGF05890 Sophora tonkinensis Sophora tonkinensis Others
BXGF05935 Pterodon emarginatus Pterodon emarginatus Others
BXGF05948 Berlinia tomentosa Berlinia tomentosa Others
BXGF05990 Carpha glomerata Carpha glomerata Others
BXGF06014 Cymodocea nodosa Cymodocea nodosa Others
BXGF06019 Picrorhiza kurrooa Picrorhiza kurrooa Medicinal Plant
BXGF06023 Hedysarum theinum Hedysarum theinum Others
BXGF06077 Bonamia spectabilis Bonamia spectabilis Others
BXGF06079 Pueraria montana var. lobata Pueraria montana var. lobata Medicinal Plant
BXGF06093 Cyanostegia angustifolia Cyanostegia angustifolia Others
BXGF06129 Atuna racemosa Atuna racemosa Human Edible Plant
BXGF06149 Orthosiphon spicatus Orthosiphon spicatus Medicinal Plant
BXGF06157 Haemanthus amarylloides Haemanthus amarylloides Others
BXGF06180 Astragalus pycnanthus Astragalus pycnanthus Others
BXGF06223 Pulsatilla campanella Pulsatilla campanella Medicinal Plant
BXGF06254 Lysimachia fordiana Lysimachia fordiana Others
BXGF06278 Ampelocera edentula Ampelocera edentula Others
BXGF06304 Ixeris debilis Ixeris debilis Others
BXGF06329 Abies excelsa Abies excelsa Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease