Showing entry for Glucagon receptor


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010592
Protein NameGlucagon receptor
Uniport IdP47871
GeneGCGR
Gene Id2642
Domain7tm_2; HRM
Pfam PF00002   PF02793  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.3 Signaling molecules and interaction hsa04080 Neuroactive ligand-receptor interaction
5. Organismal Systems 5.2 Endocrine system hsa04922 Glucagon signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Process GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Process GO:0007166 cell surface receptor signaling pathway
Biological Process GO:0071377 cellular response to glucagon stimulus
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0006887 exocytosis
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0009755 hormone-mediated signaling pathway
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0070873 regulation of glycogen metabolic process
Biological Process GO:0007584 response to nutrient
Biological Process GO:0042594 response to starvation
molecular function GO:0004967 glucagon receptor activity
molecular function GO:0008528 G protein-coupled peptide receptor activity
molecular function GO:0005085 guanyl-nucleotide exchange factor activity
molecular function GO:0017046 peptide hormone binding
cellular component GO:0005768 endosome
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000737 BXGD000005 Abdominal Pain Pathological Conditions, Signs and Symptoms
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0004153 BXGD000260 Atherosclerosis Cardiovascular Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012546 BXGD000776 Diphtheria Infections
C0017689 BXGD001148 Glucagonoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020615 BXGD001445 Hypoglycemia Nutritional and Metabolic Diseases
C0021655 BXGD001508 Insulin Resistance Nutritional and Metabolic Diseases
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030297 BXGD002204 Pancreatic Neoplasm Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0031511 BXGD002304 Pheochromocytoma Neoplasms
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0206663 BXGD004225 Neuroectodermal Tumor, Primitive Neoplasms
C0206754 BXGD004289 Neuroendocrine Tumors Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0242339 BXGD005150 Dyslipidemias Nutritional and Metabolic Diseases
C0242363 BXGD005156 Islet Cell Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0271719 BXGD006249 Glucagon resistance
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0524620 BXGD009236 Metabolic Syndrome X Nutritional and Metabolic Diseases
C0684337 BXGD009796 Ewings sarcoma-primitive neuroectodermal tumor (PNET) Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C1295677 BXGD012243 Increased glucagon level
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1318485 BXGD012394 Liver regeneration disorder Digestive System Diseases
C1337011 BXGD012874 Well Differentiated Pancreatic Endocrine Tumor Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1857451 BXGD015702 Acth-Independent Macronodular Adrenal Hyperplasia Endocrine System Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C4021086 BXGD020545 Abnormal biliary tract morphology
C4551683 BXGD023389 Adrenal Gland Pheochromocytoma Neoplasms; Endocrine System Diseases
C4703555 BXGD023658 Decreased waist to hip ratio
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0030248 2-(4-Hydroxyphenyl)Chromen-4-One 238.06
BXGC0045254 Sb-202190 331.11
BXGC0048578 Rediocide A 794.39
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein