adisease

Showing entry for Pheochromocytoma

General Disease Information
BXGD Id	BXGD002304
Disease Name	Pheochromocytoma
Disease CUI Id	C0031511
MeSH Codes	C04
Disease Class Name	Neoplasms
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0000818 HP:0000707 HP:0002664
Human Phenotype Ontology Term	Abnormality of the endocrine system; Abnormality of the nervous system; Neoplasm
Disease Ontology Id	DOID:7 DOID:14566
Disease Ontology Class Name	disease of anatomical entity; disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00255	BXGT003903	Menin	4221	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O00429	BXGT003919	Dynamin-1-like protein	10059	reviewed	Enzyme modulator
O14746	BXGT004091	Telomerase reverse transcriptase	7015	reviewed	Enzyme
O15392	BXGT004162	Baculoviral IAP repeat-containing protein 5	332	reviewed	Enzyme modulator
O43603	BXGT004604	Galanin receptor type 2	8811	reviewed	G-protein coupled receptor
O60895	BXGT004907	Receptor activity-modifying protein 2	10266	reviewed	Receptor
O75030	BXGT005096	Microphthalmia-associated transcription factor	4286	reviewed
O75390	BXGT005123	Citrate synthase, mitochondrial	1431	reviewed	Enzyme
O75874	BXGT005157	Isocitrate dehydrogenase [NADP] cytoplasmic	3417	reviewed
O76074	BXGT005174	cGMP-specific 3',5'-cyclic phosphodiesterase	8654	reviewed
O95263	BXGT005366	High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	8622	reviewed
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00739	BXGT005633	Haptoglobin-related protein	3250	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01148	BXGT005739	Progonadoliberin-1	2796	reviewed
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01215	BXGT005743	Glycoprotein hormones alpha chain	1081	reviewed
P01270	BXGT005746	Parathyroid hormone	5741	reviewed
P01275	BXGT005747	Glucagon	2641	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01583	BXGT005771	Interleukin-1 alpha	3552	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P04040	BXGT006132	Catalase	847	reviewed	Enzyme
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04626	BXGT006238	Receptor tyrosine-protein kinase erbB-2	2064	reviewed	Kinase
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P04731	BXGT006251	Metallothionein-1A	4489	reviewed
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06213	BXGT006425	Insulin receptor	3643	reviewed	Kinase
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07741	BXGT006666	Adenine phosphoribosyltransferase	353	reviewed
P07900	BXGT006696	Heat shock protein HSP 90-alpha	3320	reviewed	Chaperone
P07949	BXGT006703	Proto-oncogene tyrosine-protein kinase receptor Ret	5979	reviewed	Kinase
P08069	BXGT006723	Insulin-like growth factor 1 receptor	3480	reviewed	Kinase
P08183	BXGT006741	ATP-dependent translocase ABCB1	5243	reviewed	Transporter
P08236	BXGT006752	Beta-glucuronidase	2990	reviewed
P08833	BXGT006827	Insulin-like growth factor-binding protein 1	3484	reviewed	Enzyme modulator
P09172	BXGT006865	Dopamine beta-hydroxylase	1621	reviewed
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P0DN79	BXGT007511	Cystathionine beta-synthase-like protein	875	reviewed
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P10586	BXGT007581	Receptor-type tyrosine-protein phosphatase F	5792	reviewed	Enzyme
P10599	BXGT007583	Thioredoxin	7295	reviewed
P10644	BXGT007597	cAMP-dependent protein kinase type I-alpha regulatory subunit	5573	reviewed
P10721	BXGT007605	Mast/stem cell growth factor receptor Kit	3815	reviewed	Kinase
P10745	BXGT007608	Retinol-binding protein 3	5949	reviewed
P11086	BXGT007652	Phenylethanolamine N-methyltransferase	5409	reviewed	Enzyme
P11362	BXGT007693	Fibroblast growth factor receptor 1	2260	reviewed	Kinase
P11413	BXGT007701	Glucose-6-phosphate 1-dehydrogenase	2539	reviewed	Enzyme
P11474	BXGT007710	Steroid hormone receptor ERR1	2101	reviewed	Nuclear receptor
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P12830	BXGT007852	Cadherin-1	999	reviewed
P12931	BXGT007859	Proto-oncogene tyrosine-protein kinase Src	6714	reviewed	Kinase
P14416	BXGT008011	D(2) dopamine receptor	1813	reviewed	G-protein coupled receptor
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16455	BXGT008229	Methylated-DNA--protein-cysteine methyltransferase	4255	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P17948	BXGT008358	Vascular endothelial growth factor receptor 1	2321	reviewed	Kinase
P18075	BXGT008375	Bone morphogenetic protein 7	655	reviewed	Signaling
P20132	BXGT008546	L-serine dehydratase/L-threonine deaminase	10993	reviewed	Enzyme
P20340	BXGT008566	Ras-related protein Rab-6A	5870	reviewed
P20711	BXGT008594	Aromatic-L-amino-acid decarboxylase	1644	reviewed
P20936	BXGT008619	Ras GTPase-activating protein 1	5921	reviewed	Enzyme modulator
P21359	BXGT008640	Neurofibromin	4763	reviewed	Enzyme modulator
P21397	BXGT008644	Amine oxidase [flavin-containing] A	4128	reviewed
P21399	BXGT008646	Cytoplasmic aconitate hydratase	48	reviewed	Enzyme
P21579	BXGT008665	Synaptotagmin-1	6857	reviewed	Transporter
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P23443	BXGT008866	Ribosomal protein S6 kinase beta-1	6198	reviewed	Kinase
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23975	BXGT008935	Sodium-dependent noradrenaline transporter	6530	reviewed	Transporter
P24385	BXGT008965	G1/S-specific cyclin-D1	595	reviewed	Enzyme modulator
P24530	BXGT008975	Endothelin receptor type B	1910	reviewed	G-protein coupled receptor
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P27338	BXGT009172	Amine oxidase [flavin-containing] B	4129	reviewed
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P29320	BXGT009332	Ephrin type-A receptor 3	2042	reviewed	Kinase
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P30872	BXGT009474	Somatostatin receptor type 1	6751	reviewed	G-protein coupled receptor
P30874	BXGT009475	Somatostatin receptor type 2	6752	reviewed	G-protein coupled receptor
P31040	BXGT009503	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	6389	reviewed	Enzyme
P31749	BXGT009574	RAC-alpha serine/threonine-protein kinase	207	reviewed	Kinase
P32004	BXGT009594	Neural cell adhesion molecule L1	3897	reviewed
P32241	BXGT009613	Vasoactive intestinal polypeptide receptor 1	7433	reviewed	G-protein coupled receptor
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P35346	BXGT009813	Somatostatin receptor type 5	6755	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35520	BXGT009842	Cystathionine beta-synthase	875	reviewed
P35968	BXGT009887	Vascular endothelial growth factor receptor 2	3791	reviewed	Kinase
P36896	BXGT009940	Activin receptor type-1B	91	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P37840	BXGT010015	Alpha-synuclein	6622	reviewed	Transporter
P40337	BXGT010174	von Hippel-Lindau disease tumor suppressor	7428	reviewed	Enzyme
P40692	BXGT010195	DNA mismatch repair protein Mlh1	4292	reviewed	Nucleic acid binding
P40926	BXGT010207	Malate dehydrogenase, mitochondrial	4191	reviewed	Enzyme
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P42574	BXGT010317	Caspase-3	836	reviewed	Enzyme
P43220	BXGT010367	Glucagon-like peptide 1 receptor	2740	reviewed	G-protein coupled receptor
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46100	BXGT010508	Transcriptional regulator ATRX	546	reviewed
P46527	BXGT010525	Cyclin-dependent kinase inhibitor 1B	1027	reviewed
P46531	BXGT010526	Neurogenic locus notch homolog protein 1	4851	reviewed
P47871	BXGT010592	Glucagon receptor	2642	reviewed	G-protein coupled receptor
P48061	BXGT010616	Stromal cell-derived factor 1	6387	reviewed
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48544	BXGT010641	G protein-activated inward rectifier potassium channel 4	3762	reviewed	Ion channel
P48735	BXGT010657	Isocitrate dehydrogenase [NADP], mitochondrial	3418	reviewed
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P50052	BXGT010768	Type-2 angiotensin II receptor	186	reviewed	G-protein coupled receptor
P56937	BXGT011205	3-keto-steroid reductase	51478	reviewed
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P60880	BXGT011335	Synaptosomal-associated protein 25	6616	reviewed	Transporter
P60953	BXGT011342	Cell division control protein 42 homolog	998	reviewed	Enzyme modulator
P63000	BXGT011481	Ras-related C3 botulinum toxin substrate 1	5879	reviewed	Enzyme modulator
P63092	BXGT011495	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	2778	reviewed
P80511	BXGT011914	Protein S100-A12	6283	reviewed	Calcium-binding protein
Q00796	BXGT012549	Sorbitol dehydrogenase	6652	reviewed	Enzyme
Q01959	BXGT012624	Sodium-dependent dopamine transporter	6531	reviewed	Transporter
Q02643	BXGT012660	Growth hormone-releasing hormone receptor	2692	reviewed	G-protein coupled receptor
Q04771	BXGT012783	Activin receptor type-1	90	reviewed	Kinase
Q05940	BXGT012846	Synaptic vesicular amine transporter	6571	reviewed	Transporter
Q07075	BXGT012917	Glutamyl aminopeptidase	2028	reviewed	Enzyme
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q13085	BXGT013309	Acetyl-CoA carboxylase 1	31	reviewed
Q13563	BXGT013377	Polycystin-2	5311	reviewed	Ion channel
Q13639	BXGT013389	5-hydroxytryptamine receptor 4	3360	reviewed	G-protein coupled receptor
Q14653	BXGT013494	Interferon regulatory factor 3	3661	reviewed	Transcription factor
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15370	BXGT013561	Elongin-B	6923	reviewed	Transcription factor
Q15788	BXGT013598	Nuclear receptor coactivator 1	8648	reviewed	Kinase
Q15848	BXGT013609	Adiponectin	9370	reviewed
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16665	BXGT013653	Hypoxia-inducible factor 1-alpha	3091	reviewed	Transcription factor
Q16769	BXGT013665	Glutaminyl-peptide cyclotransferase	25797	reviewed	Enzyme
Q16790	BXGT013670	Carbonic anhydrase 9	768	reviewed
Q6UWP2	BXGT016567	Dehydrogenase/reductase SDR family member 11	79154	reviewed	Enzyme
Q86V24	BXGT017615	Adiponectin receptor protein 2	79602	reviewed	Receptor
Q96KS0	BXGT019688	Egl nine homolog 2	112398	reviewed
Q99814	BXGT019965	Endothelial PAS domain-containing protein 1	2034	reviewed	Transcription factor
Q99828	BXGT019967	Calcium and integrin-binding protein 1	10519	reviewed
Q9BYW2	BXGT020192	Histone-lysine N-methyltransferase SETD2	29072	reviewed	Epigenetic regulator
Q9GZT9	BXGT020425	Egl nine homolog 1	54583	reviewed
Q9H6Z9	BXGT020488	Egl nine homolog 3	112399	reviewed
Q9HCR9	BXGT020537	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	50940	reviewed
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q9UBN7	BXGT021658	Histone deacetylase 6	10013	reviewed	Epigenetic regulator
Q9Y251	BXGT022215	Heparanase	10855	reviewed	Enzyme
Q13029	BXGT022688	PR domain zinc finger protein 2	7799	reviewed
P19235	BXGT022895	Erythropoietin receptor	2057	reviewed	Receptor
P25054	BXGT022961	Adenomatous polyposis coli protein	324	reviewed
Q99748	BXGT023217	Neurturin	4902	reviewed	Signaling
P07954	BXGT023939	Fumarate hydratase, mitochondrial	2271	reviewed	Enzyme
O60232	BXGT024169	Protein ZNRD2	10534	reviewed
O95399	BXGT024237	Urotensin-2	10911	reviewed
Q9UKP6	BXGT024239	Urotensin-2 receptor	2837	reviewed	G-protein coupled receptor
Q96A54	BXGT024681	Adiponectin receptor protein 1	51094	reviewed	Receptor
Q9UGM3	BXGT025543	Deleted in malignant brain tumors 1 protein	1755	reviewed	Enzyme
Q92729	BXGT025605	Receptor-type tyrosine-protein phosphatase U	10076	reviewed	Enzyme
O43613	BXGT025666	Orexin receptor type 1	3061	reviewed	G-protein coupled receptor
Q9BY76	BXGT025687	Angiopoietin-related protein 4	51129	reviewed	Signaling
P11836	BXGT025994	B-lymphocyte antigen CD20	931	reviewed	Receptor
Q9UBS0	BXGT026113	Ribosomal protein S6 kinase beta-2	6199	reviewed	Kinase
Q92888	BXGT026130	Rho guanine nucleotide exchange factor 1	9138	reviewed
P07320	BXGT026150	Gamma-crystallin D	1421	reviewed

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}