Showing entry for 2-(4-Hydroxyphenyl)Chromen-4-One


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0030248
Compound Name2-(4-Hydroxyphenyl)Chromen-4-One
Structure
FormulaC15H10O3
InchiKeySHGLJXBLXNNCTE-UHFFFAOYSA-N
SMILESOc1ccc(cc1)c1cc(=O)c2c(o1)cccc2
InchiInChI=1S/C15H10O3/c16-11-7-5-10(6-8-11)15-9-13(17)12-3-1-2-4-14(12)18-15/h1-9,16H
IUPAC2-(4-hydroxyphenyl)chromen-4-one
Molecular Weight238.06
Pubchem Id229016
Chembl IdCHEMBL327209
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50011446
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT008644 Amine oxidase [flavin-containing] A reviewed MAOA 5060 - - -
reviewed BXGT009172 Amine oxidase [flavin-containing] B reviewed MAOB 1050 - - -
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - 504000 - -
reviewed BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK - 1 - -
CHEMBL CHEMBL327209
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 28183 nM
Q16637 BXGT013646 Survival motor neuron protein reviewed Epigenetic regulator SMN1 Potency '=' 12589 nM
P47871 BXGT010592 Glucagon receptor reviewed G-protein coupled receptor GCGR Activity - - -
Q03431 BXGT012714 Parathyroid hormone/parathyroid hormone-related peptide receptor reviewed G-protein coupled receptor PTH1R Activity - - -
O95149 BXGT005350 Snurportin-1 reviewed - SNUPN Potency - 25118 nM
Q14974 BXGT013516 Importin subunit beta-1 reviewed Transporter KPNB1 Potency - 25118 nM
P51151 BXGT010837 Ras-related protein Rab-9A reviewed - RAB9A Potency '=' 5623 nM
P33033 BXGT009690 Melanocortin receptor 3 reviewed - Mc3r Activity - - -
P29274 BXGT009327 Adenosine receptor A2a reviewed G-protein coupled receptor ADORA2A Activity - - -
Q64326 BXGT016112 Adrenocorticotropic hormone receptor reviewed - Mc2r Activity - - -
P41149 BXGT010228 Melanocortin receptor 5 reviewed - Mc5r Activity - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 504000 nM
P21918 BXGT008708 D(1B) dopamine receptor reviewed G-protein coupled receptor DRD5 Activity - - -
O95271 BXGT005369 Poly [ADP-ribose] polymerase tankyrase-1 reviewed - TNKS IC50 '=' 794 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 10691 nM
P32245 BXGT009614 Melanocortin receptor 4 reviewed G-protein coupled receptor MC4R Activity - - -
Q01727 BXGT012611 Melanocyte-stimulating hormone receptor reviewed - Mc1r Activity - - -
P56450 BXGT011170 Melanocortin receptor 4 reviewed - Mc4r Activity - - -
Q9HB89 BXGT020514 Neuromedin-U receptor 1 reviewed G-protein coupled receptor NMUR1 Activity - - -
P11229 BXGT007676 Muscarinic acetylcholine receptor M1 reviewed G-protein coupled receptor CHRM1 Activity - - -
P00811 BXGT005666 Beta-lactamase reviewed - ampC Potency '=' 10000 nM
P21730 BXGT008687 C5a anaphylatoxin chemotactic receptor 1 reviewed G-protein coupled receptor C5AR1 Activity - - -
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK IC50 '=' 100 ug.mL-1
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 39810 nM
O15118 BXGT004127 NPC intracellular cholesterol transporter 1 reviewed Transporter NPC1 Potency '=' 5623 nM
P38398 BXGT010037 Breast cancer type 1 susceptibility protein reviewed Enzyme BRCA1 Potency - 31622 nM
P30542 BXGT009436 Adenosine receptor A1 reviewed G-protein coupled receptor ADORA1 Activity - - -
Q9GZQ4 BXGT020422 Neuromedin-U receptor 2 reviewed G-protein coupled receptor NMUR2 EC50 - - -
O43614 BXGT004606 Orexin receptor type 2 reviewed G-protein coupled receptor HCRTR2 Activity - - -
Q99705 BXGT019951 Melanin-concentrating hormone receptor 1 reviewed G-protein coupled receptor MCHR1 Activity - - -
Q16236 BXGT013624 Nuclear factor erythroid 2-related factor 2 reviewed Enzyme NFE2L2 Potency - 2511 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 50118 nM
Q13526 BXGT013369 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 reviewed - PIN1 Potency - 39810 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 18348 nM
Q96QE3 BXGT019718 ATPase family AAA domain-containing protein 5 reviewed - ATAD5 Potency - 20587 nM
P28335 BXGT009255 5-hydroxytryptamine receptor 2C reviewed G-protein coupled receptor HTR2C Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 20596 nM
O95271 BXGT005369 Poly [ADP-ribose] polymerase tankyrase-1 reviewed - TNKS IC50 '=' 788 nM
Q01718 BXGT012609 Adrenocorticotropic hormone receptor reviewed G-protein coupled receptor MC2R Activity - - -
P41968 BXGT010275 Melanocortin receptor 3 reviewed G-protein coupled receptor MC3R Activity - - -
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency '=' 28183 nM
P0DMS8 BXGT007506 Adenosine receptor A3 reviewed G-protein coupled receptor ADORA3 Activity - - -
Q15761 BXGT013596 Neuropeptide Y receptor type 5 reviewed G-protein coupled receptor NPY5R Activity - - -
P09917 BXGT006941 Arachidonate 5-lipoxygenase reviewed Enzyme ALOX5 Inhibition '=' 38 %
P21728 BXGT008686 D(1A) dopamine receptor reviewed G-protein coupled receptor DRD1 Activity - - -
Q01726 BXGT012610 Melanocyte-stimulating hormone receptor reviewed G-protein coupled receptor MC1R Activity - - -
P43220 BXGT010367 Glucagon-like peptide 1 receptor reviewed G-protein coupled receptor GLP1R Potency - 8912 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 29092 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00046 Roman camomile Chamaemelum nobile Herbs and Spices
BXGF02518 Schkuhria multiflora Schkuhria multiflora Others
BXGF03734 Anthocleista grandiflora Anthocleista grandiflora Medicinal Plant
BXGF03743 Helleborus caucasicus Helleborus caucasicus Others
BXGF03758 Lespedeza homoloba Lespedeza homoloba Medicinal Plant
BXGF03780 Lolium perenne Lolium perenne Medicinal Plant
BXGF03793 Hypoestes serpens Hypoestes serpens Medicinal Plant
BXGF03806 Primula farinosa Primula farinosa Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease