Showing entry for Insulin Resistance


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD001508
Disease NameInsulin Resistance
Disease CUI IdC0021655
MeSH Codes C18  
Disease Class NameNutritional and Metabolic Diseases
Semantic TypePathologic Function
Human Phenotype Ontology Id HP:0001939  
Human Phenotype Ontology TermAbnormality of metabolism/homeostasis
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00763 BXGT003947 Acetyl-CoA carboxylase 2 32 reviewed
O00767 BXGT003949 Acyl-CoA desaturase 6319 reviewed
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta 3551 reviewed Kinase
O15120 BXGT004129 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 10555 reviewed
O15305 BXGT004152 Phosphomannomutase 2 5373 reviewed Enzyme
O15357 BXGT004156 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 3636 reviewed
O75844 BXGT005156 CAAX prenyl protease 1 homolog 10269 reviewed Enzyme
O95750 BXGT005395 Fibroblast growth factor 19 9965 reviewed Signaling
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P01024 BXGT005719 Complement C3 718 reviewed Enzyme modulator
P01100 BXGT005727 Proto-oncogene c-Fos 2353 reviewed Transcription factor
P01308 BXGT005749 Insulin 3630 reviewed
P01375 BXGT005753 Tumor necrosis factor 7124 reviewed Signaling
P01584 BXGT005772 Interleukin-1 beta 3553 reviewed
P02545 BXGT005889 Prelamin-A/C 4000 reviewed
P02656 BXGT005913 Apolipoprotein C-III 345 reviewed
P02787 BXGT005962 Serotransferrin 7018 reviewed Enzyme
P04179 BXGT006163 Superoxide dismutase [Mn], mitochondrial 6648 reviewed Enzyme
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P05091 BXGT006312 Aldehyde dehydrogenase, mitochondrial 217 reviewed Enzyme
P05121 BXGT006320 Plasminogen activator inhibitor 1 5054 reviewed Enzyme modulator
P05231 BXGT006345 Interleukin-6 3569 reviewed
P05771 BXGT006384 Protein kinase C beta type 5579 reviewed Kinase
P06213 BXGT006425 Insulin receptor 3643 reviewed Kinase
P07550 BXGT006636 Beta-2 adrenergic receptor 154 reviewed G-protein coupled receptor
P08842 BXGT006830 Steryl-sulfatase 412 reviewed Enzyme
P09172 BXGT006865 Dopamine beta-hydroxylase 1621 reviewed
P09601 BXGT006909 Heme oxygenase 1 3162 reviewed
P10275 BXGT007552 Androgen receptor 367 reviewed Nuclear receptor
P10644 BXGT007597 cAMP-dependent protein kinase type I-alpha regulatory subunit 5573 reviewed
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P11168 BXGT007663 Solute carrier family 2, facilitated glucose transporter member 2 6514 reviewed Transporter
P11215 BXGT007672 Integrin alpha-M 3684 reviewed
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase 2539 reviewed Enzyme
P11511 BXGT007717 Aromatase 1588 reviewed Enzyme
P13500 BXGT007916 C-C motif chemokine 2 6347 reviewed Signaling
P14410 BXGT008009 Sucrase-isomaltase, intestinal 6476 reviewed Enzyme
P14672 BXGT008037 Solute carrier family 2, facilitated glucose transporter member 4 6517 reviewed Transporter
P15090 BXGT008079 Fatty acid-binding protein, adipocyte 2167 reviewed
P16671 BXGT008255 Platelet glycoprotein 4 948 reviewed Receptor
P17861 BXGT008348 X-box-binding protein 1 7494 reviewed
P18031 BXGT008369 Tyrosine-protein phosphatase non-receptor type 1 5770 reviewed
P21554 BXGT008662 Cannabinoid receptor 1 1268 reviewed G-protein coupled receptor
P21728 BXGT008686 D(1A) dopamine receptor 1812 reviewed G-protein coupled receptor
P22352 BXGT008758 Glutathione peroxidase 3 2878 reviewed Enzyme
P22413 BXGT008764 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 5167 reviewed Enzyme
P22736 BXGT008800 Nuclear receptor subfamily 4 group A member 1 3164 reviewed Nuclear receptor
P22897 BXGT008816 Macrophage mannose receptor 1 4360 reviewed
P25942 BXGT009079 Tumor necrosis factor receptor superfamily member 5 958 reviewed
P27361 BXGT009176 Mitogen-activated protein kinase 3 5595 reviewed Kinase
P27986 BXGT009216 Phosphatidylinositol 3-kinase regulatory subunit alpha 5295 reviewed Kinase
P28845 BXGT009297 Corticosteroid 11-beta-dehydrogenase isozyme 1 3290 reviewed
P29466 BXGT009349 Caspase-1 834 reviewed Enzyme
P29474 BXGT009352 Nitric oxide synthase, endothelial 4846 reviewed
P30542 BXGT009436 Adenosine receptor A1 134 reviewed G-protein coupled receptor
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase 208 reviewed Kinase
P32245 BXGT009614 Melanocortin receptor 4 4160 reviewed G-protein coupled receptor
P35228 BXGT009800 Nitric oxide synthase, inducible 4843 reviewed
P35557 BXGT009846 Glucokinase 2645 reviewed Kinase
P35858 BXGT009876 Insulin-like growth factor-binding protein complex acid labile subunit 3483 reviewed Receptor
P35869 BXGT009877 Aryl hydrocarbon receptor 196 reviewed Transcription factor
P36955 BXGT009946 Pigment epithelium-derived factor 5176 reviewed Enzyme modulator
P36956 BXGT009947 Sterol regulatory element-binding protein 1 6720 reviewed
P37231 BXGT009972 Peroxisome proliferator-activated receptor gamma 5468 reviewed Nuclear receptor
P41235 BXGT010241 Hepatocyte nuclear factor 4-alpha 3172 reviewed Nuclear receptor
P42574 BXGT010317 Caspase-3 836 reviewed Enzyme
P46663 BXGT010531 B1 bradykinin receptor 623 reviewed G-protein coupled receptor
P47871 BXGT010592 Glucagon receptor 2642 reviewed G-protein coupled receptor
P48357 BXGT010627 Leptin receptor 3953 reviewed Signaling
P49286 BXGT010691 Melatonin receptor type 1B 4544 reviewed G-protein coupled receptor
P49908 BXGT010760 Selenoprotein P 6414 reviewed Extracellular structure
P50052 BXGT010768 Type-2 angiotensin II receptor 186 reviewed G-protein coupled receptor
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 5563 reviewed Kinase
P60484 BXGT011307 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 5728 reviewed Enzyme
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2778 reviewed
P81172 BXGT011935 Hepcidin 57817 reviewed
Q04206 BXGT012754 Transcription factor p65 5970 reviewed Transcription factor
Q04759 BXGT012781 Protein kinase C theta type 5588 reviewed Kinase
Q05655 BXGT012832 Protein kinase C delta type 5580 reviewed Kinase
Q07869 BXGT012945 Peroxisome proliferator-activated receptor alpha 5465 reviewed Nuclear receptor
Q09428 BXGT013036 ATP-binding cassette sub-family C member 8 6833 reviewed Transporter
Q12772 BXGT013262 Sterol regulatory element-binding protein 2 6721 reviewed
Q12778 BXGT013263 Forkhead box protein O1 2308 reviewed
Q13085 BXGT013309 Acetyl-CoA carboxylase 1 31 reviewed
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 5562 reviewed Kinase
Q13315 BXGT013339 Serine-protein kinase ATM 472 reviewed Kinase
Q13426 BXGT013353 DNA repair protein XRCC4 7518 reviewed
Q14191 BXGT013452 Werner syndrome ATP-dependent helicase 7486 reviewed Enzyme
Q14654 BXGT013495 ATP-sensitive inward rectifier potassium channel 11 3767 reviewed Ion channel
Q14790 BXGT013505 Caspase-8 841 reviewed Enzyme
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 6794 reviewed Kinase
Q15848 BXGT013609 Adiponectin 9370 reviewed
Q92934 BXGT019396 Bcl2-associated agonist of cell death 572 reviewed
Q96EB6 BXGT019646 NAD-dependent protein deacetylase sirtuin-1 23411 reviewed Epigenetic regulator
Q96FI4 BXGT019658 Endonuclease 8-like 1 79661 reviewed
Q9Y3D6 BXGT022257 Mitochondrial fission 1 protein 51024 reviewed
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
Q9Y6M1 BXGT025468 Insulin-like growth factor 2 mRNA-binding protein 2 10644 reviewed Enzyme
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease