Showing entry for Lanosterol synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010632
Protein NameLanosterol synthase
Uniport IdP48449
GeneLSS
Gene Id4047
DomainPrenyltrans
Pfam PF13243   PF13249  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00100 Steroid biosynthesis
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006695 cholesterol biosynthetic process
Biological Process GO:0045540 regulation of cholesterol biosynthetic process
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0006694 steroid biosynthetic process
Biological Process GO:0016104 triterpenoid biosynthetic process
molecular function GO:0042300 beta-amyrin synthase activity
molecular function GO:0000250 lanosterol synthase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0005811 lipid droplet
cellular component GO:0016020 membrane
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF)
R-HSA-191273 Cholesterol biosynthesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-556833 Metabolism of lipids
R-HSA-8957322 Metabolism of steroids
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001857 BXGD000085 AIDS related complex Infections; Immune System Diseases
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0009691 BXGD000622 Congenital cataract Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Eye Diseases; Nervous System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020498 BXGD001407 Hyperostosis, Diffuse Idiopathic Skeletal Musculoskeletal Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0020678 BXGD001463 Hypotrichosis Skin and Connective Tissue Diseases
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023794 BXGD001700 Lipoidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0028643 BXGD002079 Numbness Nervous System Diseases; Mental Disorders
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0034362 BXGD002479 Q Fever Infections
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036646 BXGD002627 Age-related cataract Eye Diseases
C0037268 BXGD002675 Skin Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0040411 BXGD002859 Tongue Neoplasms Neoplasms; Stomatognathic Diseases
C0079541 BXGD003081 Holoprosencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0085580 BXGD003191 Essential Hypertension Cardiovascular Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0158288 BXGD003879 Spinal stenosis of lumbar region Musculoskeletal Diseases
C0235031 BXGD004714 Neurologic Symptoms Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0266539 BXGD005689 Congenital total cataract Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0266667 BXGD005707 Cyclocephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0271160 BXGD006166 Cortical cataract Eye Diseases
C0276447 BXGD006425 Rhinovirus infection Infections
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0346153 BXGD007781 Breast Cancer, Familial Neoplasms; Skin and Connective Tissue Diseases
C0349566 BXGD007928 Squamous cell carcinoma of tongue Neoplasms; Stomatognathic Diseases
C0410636 BXGD008441 Degenerative lumbar spinal stenosis
C0519066 BXGD009080 Acute Q fever Infections
C0521707 BXGD009166 Bilateral cataracts (disorder) Eye Diseases
C0557874 BXGD009444 Global developmental delay
C0566602 BXGD009489 Primary sclerosing cholangitis Digestive System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0744356 BXGD010094 Abnormality of the genital system Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0854924 BXGD011052 Papillary serous endometrial carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0858617 BXGD011183 Posterior subcapsular cataract Eye Diseases
C1261473 BXGD011855 Sarcoma Neoplasms
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335177 BXGD012771 Ovarian Serous Adenocarcinoma Neoplasms
C1443892 BXGD013073 Chronic Q Fever Infections
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1843300 BXGD014572 Sparse eyelashes
C1854310 BXGD015392 Hypotrichosis simplex Skin and Connective Tissue Diseases
C1862863 BXGD016138 Sparse body hair
C1865343 BXGD016316 OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases
C1873509 BXGD016554 Hypotrichosis of the scalp
C2880562 BXGD017841 Age-related cortical cataract
C2973787 BXGD018206 Coxiella burnetii Infection Infections
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3665386 BXGD019284 Abnormal vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4225300 BXGD022215 CATARACT 44
C4282407 BXGD022423 Sparse and thin eyebrow
C4551686 BXGD023391 Malignant neoplasm of soft tissue Neoplasms
C4551986 BXGD023466 AMR Syndrome Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4748930 BXGD024040 HYPOTRICHOSIS 14
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003138 N-Tetradecane 198.39
BXGC0006990 Lanosterol 426.72
BXGC0042373 N,N-Dimethyldodecan-1-Amine Oxide 229.24
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein