Showing entry for Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT012864
Protein NameGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Uniport IdQ06210
GeneGFPT1
Gene Id2673
DomainSIS
Pfam PF01380  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00520 Amino sugar and nucleotide sugar metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04931 Insulin resistance
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006112 energy reserve metabolic process
Biological Process GO:0006002 fructose 6-phosphate metabolic process
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0036498 IRE1-mediated unfolded protein response
Biological Process GO:0006487 protein N-linked glycosylation
Biological Process GO:0006048 UDP-N-acetylglucosamine biosynthetic process
Biological Process GO:0006047 UDP-N-acetylglucosamine metabolic process
molecular function GO:0097367 carbohydrate derivative binding
molecular function GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
R-HSA-1643685 Disease
R-HSA-3781865 Diseases of glycosylation
R-HSA-381038 XBP1(S) activates chaperone genes
R-HSA-381070 IRE1alpha activates chaperones
R-HSA-381119 Unfolded Protein Response (UPR)
R-HSA-392499 Metabolism of proteins
R-HSA-4085023 Defective GFPT1 causes CMSTA1
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-5609975 Diseases associated with glycosylation precursor biosynthesis
R-HSA-5668914 Diseases of metabolism
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003886 BXGD000238 Arthrogryposis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006118 BXGD000372 Brain Neoplasms Neoplasms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011168 BXGD000700 Deglutition Disorders Digestive System Diseases; Otorhinolaryngologic Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015469 BXGD000996 Facial paralysis Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Stomatognathic Diseases
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0019163 BXGD001295 Hepatitis B Digestive System Diseases; Infections
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0020476 BXGD001398 Hyperlipoproteinemias Nutritional and Metabolic Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0030552 BXGD002238 Paresis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0037763 BXGD002699 Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0086437 BXGD003282 Joint laxity Musculoskeletal Diseases
C0151786 BXGD003475 Muscle Weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0231712 BXGD004519 Waddling gait Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234182 BXGD004631 Gowers sign
C0234860 BXGD004698 Weak cry
C0235659 BXGD004763 Reduced fetal movement Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0239067 BXGD004961 Difficulty walking up stairs Pathological Conditions, Signs and Symptoms
C0240479 BXGD005039 Neck muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0240953 BXGD005067 Winged scapula
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0311394 BXGD006884 Difficulty walking Pathological Conditions, Signs and Symptoms
C0333768 BXGD006968 Tubular aggregates
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0393933 BXGD008157 Pseudomyopathic myasthenia
C0399526 BXGD008251 Class III malocclusion Stomatognathic Diseases
C0410207 BXGD008419 Tubular Aggregate Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0427065 BXGD008604 Distal muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0518026 BXGD009069 body fat percentage (physical finding)
C0520947 BXGD009126 Clumsiness - motor delay Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0541794 BXGD009262 Skeletal muscle atrophy
C0560346 BXGD009475 Difficulty running Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0751401 BXGD010427 Ophthalmoparesis Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0751882 BXGD010626 Myasthenic Syndromes, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751883 BXGD010627 Congenital Myasthenic Syndromes, Postsynaptic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751884 BXGD010628 Congenital Myasthenic Syndromes, Presynaptic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751885 BXGD010629 Myasthenic Syndromes, Congenital, Slow Channel Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0751950 BXGD010647 Neuromuscular Junction Diseases Nervous System Diseases
C0850703 BXGD010905 Frequent falls Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0947912 BXGD011497 Myasthenias Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1184923 BXGD011800 Lumbar hyperlordosis Musculoskeletal Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1305855 BXGD012348 Body mass index
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836038 BXGD014073 Poor head control Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1836047 BXGD014074 Long face
C1837091 BXGD014196 MYASTHENIC SYNDROME, CONGENITAL, ASSOCIATED WITH ACETYLCHOLINE RECEPTOR DEFICIENCY Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837098 BXGD014198 Easy fatigability
C1837108 BXGD014199 Decreased muscle mass
C1850794 BXGD015178 Proximal amyotrophy
C1854301 BXGD015391 Motor delay Mental Disorders
C1854387 BXGD015396 Type 1 muscle fiber predominance
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858127 BXGD015775 Limb-girdle muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1861403 BXGD016045 Variable expressivity
C1864580 BXGD016235 Type 2 muscle fiber atrophy
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2931822 BXGD018068 Nasopharyngeal carcinoma Neoplasms; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C3275417 BXGD018663 Ragged-red muscle fibers
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3552335 BXGD019152 MYASTHENIC SYNDROME, CONGENITAL, 12
C3806467 BXGD019513 Respiratory insufficiency due to muscle weakness Respiratory Tract Diseases
C3839460 BXGD019773 Nonprogressive
C4021024 BXGD020522 Muscle fiber tubular inclusions
C4021045 BXGD020533 Increased jitter at single fibre EMG
C4021728 BXGD020737 EMG: decremental response of compound muscle action potential to repetitive nerve stimulation
C4021753 BXGD020758 Abnormality of the immune system
C4022581 BXGD020923 Favorable response of weakness to acetylcholine esterase inhibitors
C4024605 BXGD021336 Generalized weakness of limb muscles
C4025615 BXGD021696 Decreased size of nerve terminals
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0002588 Magnesium 24.31
BXGC0003705 Chloride 35.45
BXGC0006162 L-Glutamic acid 147.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein