Showing entry for Mitogen-activated protein kinase kinase kinase kinase 2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013271
Protein NameMitogen-activated protein kinase kinase kinase kinase 2
Uniport IdQ12851
GeneMAP4K2
Gene Id5871
DomainCNH; Pkinase
Pfam PF00780   PF00069  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007257 activation of JUN kinase activity
Biological Process GO:0006955 immune response
Biological Process GO:0045087 innate immune response
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0007254 JNK cascade
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0006903 vesicle targeting
molecular function GO:0005524 ATP binding
molecular function GO:0008349 MAP kinase kinase kinase kinase activity
molecular function GO:0031435 mitogen-activated protein kinase kinase kinase binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0000139 Golgi membrane
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003868 BXGD000233 Arthritis, Gouty Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0018099 BXGD001172 Gout Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases
C0202239 BXGD004087 Uric acid measurement (procedure)
C0342276 BXGD007449 Maturity onset diabetes mellitus in young Nutritional and Metabolic Diseases; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0012352 Chelerythrine 348.12
BXGC0015879 Chlorhexidine 504.2
BXGC0024554 D-luciferin 280
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein