Showing entry for D-luciferin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0024554
Compound NameD-luciferin
Structure
FormulaC11H8N2O3S2
InchiKeyBJGNCJDXODQBOB-SSDOTTSWSA-N
SMILESOC(=O)[C@H]1CSC(=N1)c1nc2c(s1)cc(cc2)O
InchiInChI=1S/C11H8N2O3S2/c14-5-1-2-6-8(3-5)18-10(12-6)9-13-7(4-17-9)11(15)16/h1-3,7,14H,4H2,(H,15,16)/t7-/m1/s1
IUPAC
Molecular Weight280
Pubchem Id92934
Chembl IdCHEMBL443738
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB ESJ
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed CDK2 Kinase - - - -
Binding DB 50440036
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 - - - 12900
reviewed BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 - - - 277000
reviewed BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 9860 - - -
CHEMBL CHEMBL443738
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 reviewed Kinase KDR Activity '=' 14 %
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 reviewed Kinase FLT4 Activity '=' 14 %
P17948 BXGT008358 Vascular endothelial growth factor receptor 1 reviewed Kinase FLT1 Activity '=' 14 %
O00418 BXGT003918 Eukaryotic elongation factor 2 kinase reviewed Kinase EEF2K Activity '=' 53 %
Q86Z02 BXGT017638 Homeodomain-interacting protein kinase 1 reviewed Kinase HIPK1 Activity '=' 63 %
Q16539 BXGT013634 Mitogen-activated protein kinase 14 reviewed Kinase MAPK14 Activity '=' 97 %
P43405 BXGT010386 Tyrosine-protein kinase SYK reviewed Kinase SYK Activity '=' 68 %
Q13188 BXGT013324 Serine/threonine-protein kinase 3 reviewed Kinase STK3 Activity '=' 48 %
Q16816 BXGT013673 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform reviewed Kinase PHKG1 Activity '=' 32 %
Q93100 BXGT019462 Phosphorylase b kinase regulatory subunit beta reviewed Enzyme modulator PHKB Activity '=' 32 %
P46019 BXGT010498 Phosphorylase b kinase regulatory subunit alpha, liver isoform reviewed Kinase PHKA2 Activity '=' 32 %
P46020 BXGT010499 Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform reviewed Kinase PHKA1 Activity '=' 32 %
P15735 BXGT008151 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform reviewed Kinase PHKG2 Activity '=' 32 %
Q16584 BXGT013642 Mitogen-activated protein kinase kinase kinase 11 reviewed Kinase MAP3K11 Activity '=' 37 %
P49841 BXGT010750 Glycogen synthase kinase-3 beta reviewed Kinase GSK3B Activity '=' 27 %
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 Ki '=' 9860 nM
P23443 BXGT008866 Ribosomal protein S6 kinase beta-1 reviewed Kinase RPS6KB1 Activity '=' 39 %
Q13177 BXGT013323 Serine/threonine-protein kinase PAK 2 reviewed Kinase PAK2 Activity '=' 70 %
P51955 BXGT010908 Serine/threonine-protein kinase Nek2 reviewed Kinase NEK2 Activity '=' 41 %
O96013 BXGT005414 Serine/threonine-protein kinase PAK 4 reviewed Kinase PAK4 Activity '=' 39 %
Q8N4C8 BXGT018510 Misshapen-like kinase 1 reviewed Kinase MINK1 Activity '=' 29 %
P54764 BXGT011078 Ephrin type-A receptor 4 reviewed Kinase EPHA4 Activity '=' 80 %
P45984 BXGT010495 Mitogen-activated protein kinase 9 reviewed Kinase MAPK9 Activity '=' 92 %
P54753 BXGT011073 Ephrin type-B receptor 3 reviewed Kinase EPHB3 Activity '=' 38 %
Q9NWZ3 BXGT021239 Interleukin-1 receptor-associated kinase 4 reviewed Kinase IRAK4 Activity '=' 60 %
Q8IW41 BXGT018352 MAP kinase-activated protein kinase 5 reviewed Kinase MAPKAPK5 Activity '=' 60 %
Q96SB4 BXGT019740 SRSF protein kinase 1 reviewed Kinase SRPK1 Activity '=' 29 %
O75116 BXGT005100 Rho-associated protein kinase 2 reviewed Kinase ROCK2 Activity '=' 16 %
Q14012 BXGT013437 Calcium/calmodulin-dependent protein kinase type 1 reviewed Kinase CAMK1 Activity '=' 52 %
P20248 BXGT008554 Cyclin-A2 reviewed Enzyme modulator CCNA2 Activity '=' 39 %
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Activity '=' 39 %
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 EC50 '=' 277000 nM
Q15831 BXGT013604 Serine/threonine-protein kinase STK11 reviewed Kinase STK11 Activity '=' 58 %
Q05513 BXGT012820 Protein kinase C zeta type reviewed Kinase PRKCZ Activity '=' 50 %
Q9UGI9 BXGT021682 5'-AMP-activated protein kinase subunit gamma-3 reviewed Enzyme modulator PRKAG3 Activity '=' 48 %
Q13131 BXGT013314 5'-AMP-activated protein kinase catalytic subunit alpha-1 reviewed Kinase PRKAA1 Activity '=' 48 %
Q9Y478 BXGT022271 5'-AMP-activated protein kinase subunit beta-1 reviewed Kinase PRKAB1 Activity '=' 48 %
Q9UGJ0 BXGT021683 5'-AMP-activated protein kinase subunit gamma-2 reviewed Enzyme modulator PRKAG2 Activity '=' 48 %
P54619 BXGT011060 5'-AMP-activated protein kinase subunit gamma-1 reviewed Kinase PRKAG1 Activity '=' 48 %
O43741 BXGT004620 5'-AMP-activated protein kinase subunit beta-2 reviewed Enzyme modulator PRKAB2 Activity '=' 48 %
P54646 BXGT011062 5'-AMP-activated protein kinase catalytic subunit alpha-2 reviewed Kinase PRKAA2 Activity '=' 48 %
P41240 BXGT010242 Tyrosine-protein kinase CSK reviewed Kinase CSK Activity '=' 93 %
Q15759 BXGT013595 Mitogen-activated protein kinase 11 reviewed Kinase MAPK11 Activity '=' 83 %
P48730 BXGT010656 Casein kinase I isoform delta reviewed Kinase CSNK1D Activity '=' 43 %
Q06187 BXGT012860 Tyrosine-protein kinase BTK reviewed Kinase BTK Activity '=' 36 %
P45983 BXGT010494 Mitogen-activated protein kinase 8 reviewed Kinase MAPK8 Activity '=' 85 %
P27361 BXGT009176 Mitogen-activated protein kinase 3 reviewed Kinase MAPK3 Activity '=' 48 %
O43318 BXGT004586 Mitogen-activated protein kinase kinase kinase 7 reviewed Kinase MAP3K7 Activity '=' 59 %
Q9H2X6 BXGT020458 Homeodomain-interacting protein kinase 2 reviewed Kinase HIPK2 Activity '=' 20 %
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 Activity '=' 82 %
P54760 BXGT011075 Ephrin type-B receptor 4 reviewed Kinase EPHB4 Activity '=' 72 %
Q7KZI7 BXGT016990 Serine/threonine-protein kinase MARK2 reviewed Kinase MARK2 Activity '=' 59 %
O14920 BXGT004110 Inhibitor of nuclear factor kappa-B kinase subunit beta reviewed Kinase IKBKB Activity '=' 65 %
O96017 BXGT005415 Serine/threonine-protein kinase Chk2 reviewed Kinase CHEK2 Activity '=' 28 %
P19784 BXGT008513 Casein kinase II subunit alpha' reviewed Kinase CSNK2A2 Activity '=' 7 %
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 Activity '=' 7 %
P67870 BXGT011566 Casein kinase II subunit beta reviewed Kinase CSNK2B Activity '=' 7 %
Q9P286 BXGT021299 Serine/threonine-protein kinase PAK 5 reviewed Kinase PAK5 Activity '=' 66 %
Q15139 BXGT013546 Serine/threonine-protein kinase D1 reviewed Kinase PRKD1 Activity '=' 49 %
P04629 BXGT006239 High affinity nerve growth factor receptor reviewed Kinase NTRK1 Activity '=' 34 %
Q15746 BXGT013591 Myosin light chain kinase, smooth muscle reviewed Kinase MYLK Activity '=' 51 %
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 Activity '=' 11 %
P53778 BXGT011013 Mitogen-activated protein kinase 12 reviewed Kinase MAPK12 Activity '=' 90 %
O15264 BXGT004144 Mitogen-activated protein kinase 13 reviewed Kinase MAPK13 Activity '=' 93 %
P49137 BXGT010680 MAP kinase-activated protein kinase 2 reviewed Kinase MAPKAPK2 Activity '=' 38 %
Q9P289 BXGT021300 Serine/threonine-protein kinase 26 reviewed Kinase STK26 Activity '=' 75 %
P11362 BXGT007693 Fibroblast growth factor receptor 1 reviewed Kinase FGFR1 Activity '=' 23 %
Q9H422 BXGT020469 Homeodomain-interacting protein kinase 3 reviewed Kinase HIPK3 Activity '=' 53 %
Q9HBH9 BXGT020521 MAP kinase-interacting serine/threonine-protein kinase 2 reviewed Kinase MKNK2 Activity '=' 17 %
Q13233 BXGT013330 Mitogen-activated protein kinase kinase kinase 1 reviewed Kinase MAP3K1 Activity '=' 82 %
O14965 BXGT004117 Aurora kinase A reviewed Kinase AURKA Activity '=' 16 %
O00141 BXGT003882 Serine/threonine-protein kinase Sgk1 reviewed Kinase SGK1 Activity '=' 31 %
Q14164 BXGT013451 Inhibitor of nuclear factor kappa-B kinase subunit epsilon reviewed Kinase IKBKE Activity '=' 52 %
Q9P1W9 BXGT021296 Serine/threonine-protein kinase pim-2 reviewed Kinase PIM2 Activity '=' 35 %
P53779 BXGT011014 Mitogen-activated protein kinase 10 reviewed Kinase MAPK10 Activity '=' 79 %
Q14680 BXGT013499 Maternal embryonic leucine zipper kinase reviewed Kinase MELK Activity '=' 49 %
Q9BUB5 BXGT020133 MAP kinase-interacting serine/threonine-protein kinase 1 reviewed Kinase MKNK1 Activity '=' 23 %
P14616 BXGT008026 Insulin receptor-related protein reviewed Kinase INSRR Activity '=' 36 %
P06239 BXGT006427 Tyrosine-protein kinase Lck reviewed Kinase LCK Activity '=' 83 %
Q9P0L2 BXGT021289 Serine/threonine-protein kinase MARK1 reviewed Kinase MARK1 Activity '=' 35 %
O15530 BXGT004177 3-phosphoinositide-dependent protein kinase 1 reviewed Kinase PDPK1 Activity '=' 75 %
P07947 BXGT006701 Tyrosine-protein kinase Yes reviewed Kinase YES1 Activity '=' 75 %
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 Tm '=' 47 degrees C
P80192 BXGT011883 Mitogen-activated protein kinase kinase kinase 9 reviewed Kinase MAP3K9 Activity '=' 37 %
O60285 BXGT004867 NUAK family SNF1-like kinase 1 reviewed Kinase NUAK1 Activity '=' 28 %
Q9HC97 BXGT020527 G-protein coupled receptor 35 reviewed G-protein coupled receptor GPR35 EC50 '=' 12900 nM
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB Activity '=' 6 %
O43781 BXGT004625 Dual specificity tyrosine-phosphorylation-regulated kinase 3 reviewed Kinase DYRK3 Activity '=' 5 %
P17252 BXGT008294 Protein kinase C alpha type reviewed Kinase PRKCA Activity '=' 69 %
Q9UHD2 BXGT021697 Serine/threonine-protein kinase TBK1 reviewed Kinase TBK1 Activity '=' 64 %
P31751 BXGT009576 RAC-beta serine/threonine-protein kinase reviewed Kinase AKT2 Activity '=' 14 %
Q8TD08 BXGT018803 Mitogen-activated protein kinase 15 reviewed Kinase MAPK15 Activity '=' 15 %
P27448 BXGT009183 MAP/microtubule affinity-regulating kinase 3 reviewed Kinase MARK3 Activity '=' 40 %
Q86V86 BXGT017617 Serine/threonine-protein kinase pim-3 reviewed - PIM3 Activity '=' 16 %
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC Activity '=' 99 %
O14757 BXGT004092 Serine/threonine-protein kinase Chk1 reviewed Kinase CHEK1 Activity '=' 91 %
Q9NQU5 BXGT021169 Serine/threonine-protein kinase PAK 6 reviewed - PAK6 Activity '=' 92 %
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Activity '=' 57 %
Q9HC98 BXGT020528 Serine/threonine-protein kinase Nek6 reviewed Kinase NEK6 Activity '=' 75 %
O60674 BXGT004892 Tyrosine-protein kinase JAK2 reviewed Kinase JAK2 Activity '=' 66 %
Q16513 BXGT013632 Serine/threonine-protein kinase N2 reviewed Kinase PKN2 Activity '=' 68 %
P29317 BXGT009331 Ephrin type-A receptor 2 reviewed Kinase EPHA2 Activity '=' 96 %
Q96RR4 BXGT019734 Calcium/calmodulin-dependent protein kinase kinase 2 reviewed Kinase CAMKK2 Activity '=' 36 %
P08069 BXGT006723 Insulin-like growth factor 1 receptor reviewed Kinase IGF1R Activity '=' 50 %
P33981 BXGT009744 Dual specificity protein kinase TTK reviewed Kinase TTK Activity '=' 54 %
Q8TDC3 BXGT018808 Serine/threonine-protein kinase BRSK1 reviewed Kinase BRSK1 Activity '=' 24 %
Q15303 BXGT013557 Receptor tyrosine-protein kinase erbB-4 reviewed Kinase ERBB4 Activity '=' 24 %
Q12851 BXGT013271 Mitogen-activated protein kinase kinase kinase kinase 2 reviewed Kinase MAP4K2 Activity '=' 15 %
Q8IWQ3 BXGT018355 Serine/threonine-protein kinase BRSK2 reviewed Kinase BRSK2 Activity '=' 31 %
P51812 BXGT010893 Ribosomal protein S6 kinase alpha-3 reviewed Kinase RPS6KA3 Activity '=' 15 %
P11309 BXGT007685 Serine/threonine-protein kinase pim-1 reviewed Kinase PIM1 Activity '=' 33 %
Q16644 BXGT013647 MAP kinase-activated protein kinase 3 reviewed Kinase MAPKAPK3 Activity '=' 33 %
Q92630 BXGT019360 Dual specificity tyrosine-phosphorylation-regulated kinase 2 reviewed Kinase DYRK2 Activity '=' 4 %
O43353 BXGT004589 Receptor-interacting serine/threonine-protein kinase 2 reviewed Kinase RIPK2 Activity '=' 53 %
Q96L34 BXGT019689 MAP/microtubule affinity-regulating kinase 4 reviewed Kinase MARK4 Activity '=' 57 %
Q02750 BXGT012662 Dual specificity mitogen-activated protein kinase kinase 1 reviewed Kinase MAP2K1 Activity '=' 51 %
P06213 BXGT006425 Insulin receptor reviewed Kinase INSR Activity '=' 35 %
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Activity '=' 87 %
Q15418 BXGT013569 Ribosomal protein S6 kinase alpha-1 reviewed Kinase RPS6KA1 Activity '=' 47 %
O75582 BXGT005137 Ribosomal protein S6 kinase alpha-5 reviewed Kinase RPS6KA5 Activity '=' 44 %
Q13627 BXGT013385 Dual specificity tyrosine-phosphorylation-regulated kinase 1A reviewed Kinase DYRK1A Activity '=' 4 %
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF04435 Derris scandens Derris scandens Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease