Showing entry for Disks large homolog 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013283
Protein NameDisks large homolog 1
Uniport IdQ12959
GeneDLG1
Gene Id1739
DomainGuanylate_kin; L27_1; MAGUK_N_PEST; PDZ; PDZ_assoc; SH3_1
Pfam PF00625   PF09058   PF10608   PF00595   PF10600   PF00018  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04390 Hippo signaling pathway
4. Cellular Processes 4.3 Cellular community - eukaryotes hsa04530 Tight junction
5. Organismal Systems 5.1 Immune system hsa04660 T cell receptor signaling pathway
6. Human Diseases 6.9 Infectious diseases: Viral hsa05165 Human papillomavirus infection
6. Human Diseases 6.9 Infectious diseases: Viral hsa05166 Human T-cell leukemia virus 1 infection
6. Human Diseases 6.1 Cancers: Overview hsa05203 Viral carcinogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007015 actin filament organization
Biological Process GO:0032147 activation of protein kinase activity
Biological Process GO:0042982 amyloid precursor protein metabolic process
Biological Process GO:0030953 astral microtubule organization
Biological Process GO:0070830 bicellular tight junction assembly
Biological Process GO:0001658 branching involved in ureteric bud morphogenesis
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0034629 cellular protein-containing complex localization
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0030866 cortical actin cytoskeleton organization
Biological Process GO:0043622 cortical microtubule organization
Biological Process GO:0048704 embryonic skeletal system morphogenesis
Biological Process GO:0001935 endothelial cell proliferation
Biological Process GO:0051660 establishment of centrosome localization
Biological Process GO:0007163 establishment or maintenance of cell polarity
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0060022 hard palate development
Biological Process GO:0001771 immunological synapse formation
Biological Process GO:0002088 lens development in camera-type eye
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0031579 membrane raft organization
Biological Process GO:0007093 mitotic cell cycle checkpoint
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0045930 negative regulation of mitotic cell cycle
Biological Process GO:1903753 negative regulation of p38MAPK cascade
Biological Process GO:0051898 negative regulation of protein kinase B signaling
Biological Process GO:0042130 negative regulation of T cell proliferation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
Biological Process GO:0030432 peristalsis
Biological Process GO:0030838 positive regulation of actin filament polymerization
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0043268 positive regulation of potassium ion transport
Biological Process GO:1903078 positive regulation of protein localization to plasma membrane
Biological Process GO:0072659 protein localization to plasma membrane
Biological Process GO:0043113 receptor clustering
Biological Process GO:0097120 receptor localization to synapse
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0031641 regulation of myelination
Biological Process GO:2000310 regulation of NMDA receptor activity
Biological Process GO:1903764 regulation of potassium ion export across plasma membrane
Biological Process GO:1903286 regulation of potassium ion import
Biological Process GO:1902473 regulation of protein localization to synapse
Biological Process GO:1902305 regulation of sodium ion transmembrane transport
Biological Process GO:0098911 regulation of ventricular cardiac muscle cell action potential
Biological Process GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Biological Process GO:0048608 reproductive structure development
Biological Process GO:0048745 smooth muscle tissue development
Biological Process GO:0042110 T cell activation
Biological Process GO:0002369 T cell cytokine production
Biological Process GO:0016032 viral process
molecular function GO:0045296 cadherin binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0004385 guanylate kinase activity
molecular function GO:0044325 ion channel binding
molecular function GO:0097016 L27 domain binding
molecular function GO:0031434 mitogen-activated protein kinase kinase binding
molecular function GO:0060090 molecular adaptor activity
molecular function GO:0019902 phosphatase binding
molecular function GO:0004721 phosphoprotein phosphatase activity
molecular function GO:0015459 potassium channel regulator activity
molecular function GO:0008022 protein C-terminus binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0098919 structural constituent of postsynaptic density
cellular component GO:0016324 apical plasma membrane
cellular component GO:0005604 basement membrane
cellular component GO:0016323 basolateral plasma membrane
cellular component GO:0005923 bicellular tight junction
cellular component GO:0005911 cell-cell junction
cellular component GO:0030054 cell junction
cellular component GO:0031253 cell projection membrane
cellular component GO:0005737 cytoplasm
cellular component GO:0009898 cytoplasmic side of plasma membrane
cellular component GO:0005829 cytosol
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0070062 extracellular exosome
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0005794 Golgi apparatus
cellular component GO:0001772 immunological synapse
cellular component GO:0014704 intercalated disc
cellular component GO:0043219 lateral loop
cellular component GO:0016328 lateral plasma membrane
cellular component GO:0045121 membrane raft
cellular component GO:0005874 microtubule
cellular component GO:0097025 MPP7-DLG1-LIN7 complex
cellular component GO:0035748 myelin sheath abaxonal region
cellular component GO:0031594 neuromuscular junction
cellular component GO:0043005 neuron projection
cellular component GO:0033268 node of Ranvier
cellular component GO:0005634 nucleus
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0005886 plasma membrane
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0042383 sarcolemma
cellular component GO:0097060 synaptic membrane
Reactome
Pathway Id Pathway Name
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-373760 L1CAM interactions
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-422475 Axon guidance
R-HSA-438064 Post NMDA receptor activation events
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442755 Activation of NMDA receptors and postsynaptic events
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-447038 NrCAM interactions
R-HSA-451306 Ionotropic activity of kainate receptors
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-451326 Activation of kainate receptors upon glutamate binding
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6794362 Protein-protein interactions at synapses
R-HSA-8849932 Synaptic adhesion-like molecules
R-HSA-9607240 FLT3 Signaling
R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors
R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission
R-HSA-9620244 Long-term potentiation
R-HSA-9675108 Nervous system development
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0005695 BXGD000323 Bladder Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007873 BXGD000500 Uterine Cervical Neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0008925 BXGD000575 Cleft Palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0009375 BXGD000602 Colonic Neoplasms Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020295 BXGD001372 Hydronephrosis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0023493 BXGD001672 Adult T-Cell Lymphoma/Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024636 BXGD001793 Malocclusion Stomatognathic Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0042454 BXGD002983 Velopharyngeal Insufficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases; Otorhinolaryngologic Diseases
C0042834 BXGD003004 Vital capacity
C0158646 BXGD003897 Cleft palate with cleft lip Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0205682 BXGD004105 Waist-Hip Ratio
C0240310 BXGD005030 Hypoplasia of the maxilla
C0266316 BXGD005651 Congenital hydronephrosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0267071 BXGD005730 Oropharyngeal Dysphagia Digestive System Diseases; Otorhinolaryngologic Diseases
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0376634 BXGD008006 Craniofacial Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0454644 BXGD008850 Delayed speech and language development Behavior and Behavior Mechanisms
C0566620 BXGD009490 Nasal voice
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0699885 BXGD009869 Carcinoma of bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0747085 BXGD010158 Recurrent otitis media Otorhinolaryngologic Diseases
C0810364 BXGD010846 Cleft Lip with or without Cleft Palate
C1302773 BXGD012312 Low Grade Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1656427 BXGD013485 Early onset schizophrenia
C1698581 BXGD013519 Rokitansky Kuster Hauser syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C1837142 BXGD014201 Poor suck
C1837218 BXGD014207 Cleft palate, isolated Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1859363 BXGD015880 Abnormality of dental eruption
C1865313 BXGD016311 Speech articulation difficulties
C2032780 BXGD016887 Palate fistula
C2062441 BXGD016897 Influenza A
C2674949 BXGD017261 Chromosome 3q29 Deletion Syndrome Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3553084 BXGD019163 Bilateral cleft palate
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021881 BXGD020826 Agenesis of lateral incisor
C4022143 BXGD020883 Unilateral cleft palate
C4023573 BXGD021218 Abnormal number of permanent teeth
C4025060 BXGD021538 Peg-shaped maxillary lateral incisors
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein