Showing entry for Receptor-type tyrosine-protein phosphatase kappa


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT013555
Protein NameReceptor-type tyrosine-protein phosphatase kappa
Uniport IdQ15262
GenePTPRK
Gene Id5796
Domainfn3; I-set; MAM; Y_phosphatase
Pfam PF00041   PF07679   PF00629   PF00102  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007155 cell adhesion
Biological Process GO:0016477 cell migration
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0034644 cellular response to UV
Biological Process GO:0048041 focal adhesion assembly
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0010839 negative regulation of keratinocyte proliferation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0031175 neuron projection development
Biological Process GO:0006470 protein dephosphorylation
Biological Process GO:0034394 protein localization to cell surface
Biological Process GO:0007165 signal transduction
Biological Process GO:0030217 T cell differentiation
Biological Process GO:0007179 transforming growth factor beta receptor signaling pathway
molecular function GO:0008013 beta-catenin binding
molecular function GO:0045295 gamma-catenin binding
molecular function GO:0019901 protein kinase binding
molecular function GO:0004725 protein tyrosine phosphatase activity
molecular function GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
cellular component GO:0005912 adherens junction
cellular component GO:0030424 axon
cellular component GO:0005911 cell-cell junction
cellular component GO:0030054 cell junction
cellular component GO:0009986 cell surface
cellular component GO:0030425 dendrite
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0031256 leading edge membrane
cellular component GO:0043025 neuronal cell body
cellular component GO:0001750 photoreceptor outer segment
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-177929 Signaling by EGFR
R-HSA-182971 EGFR downregulation
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014548 BXGD000928 Epilepsy, Generalized Nervous System Diseases
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0025202 BXGD001832 melanoma Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0079772 BXGD003099 T-Cell Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0264408 BXGD005387 Childhood asthma Respiratory Tract Diseases; Immune System Diseases
C0280803 BXGD006766 Primary central nervous system lymphoma Neoplasms; Immune System Diseases; Nervous System Diseases; Hemic and Lymphatic Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0410702 BXGD008447 Adolescent idiopathic scoliosis Musculoskeletal Diseases
C0455829 BXGD008859 Waist Circumference
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0678909 BXGD009757 Brain Waves
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1266025 BXGD011935 Traditional Serrated Adenoma Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1333116 BXGD012598 Colorectal Traditional Serrated Adenoma
C1527304 BXGD013266 Allergic Reaction Immune System Diseases
C1837461 BXGD014234 SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein