Showing entry for Glutaredoxin-related protein 5, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017601
Protein NameGlutaredoxin-related protein 5, mitochondrial
Uniport IdQ86SX6
GeneGLRX5
Gene Id51218
DomainGlutaredoxin
Pfam PF00462  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030097 hemopoiesis
Biological Process GO:0009249 protein lipoylation
Biological Process GO:0044281 small molecule metabolic process
molecular function GO:0051537 2 iron, 2 sulfur cluster binding
molecular function GO:0009055 electron transfer activity
molecular function GO:0046872 metal ion binding
molecular function GO:0015035 protein disulfide oxidoreductase activity
cellular component GO:0030425 dendrite
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis
R-HSA-1430728 Metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002896 BXGD000153 Sideroblastic anemia Hemic and Lymphatic Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004610 BXGD000281 Bacteremia Pathological Conditions, Signs and Symptoms; Infections
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0014772 BXGD000948 Red Blood Cell Count measurement
C0014800 BXGD000950 Erythroid hyperplasia Pathological Conditions, Signs and Symptoms
C0016719 BXGD001074 Friedreich Ataxia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0019214 BXGD001307 Hepatosplenomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Hemic and Lymphatic Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023882 BXGD001710 Little's Disease Nervous System Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0034935 BXGD002497 Babinski Reflex
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0149721 BXGD003349 Left Ventricular Hypertrophy Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0221018 BXGD004366 Hereditary sideroblastic anemia Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0221278 BXGD004435 Anisocytosis
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0232466 BXGD004543 Feeding difficulties
C0238644 BXGD004949 Anemia, severe Hemic and Lymphatic Diseases
C0241013 BXGD005075 Increased serum ferritin
C0241224 BXGD005087 Spinal cord lesion Nervous System Diseases
C0262630 BXGD005262 Reduced concentration span Behavior and Behavior Mechanisms
C0268307 BXGD005892 Conjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0268559 BXGD005984 Hyperglycinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0282193 BXGD006798 Iron Overload Nutritional and Metabolic Diseases
C0333912 BXGD006973 Hypochromatism
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0344482 BXGD007678 Hypoplasia of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0454596 BXGD008842 Dysarthria, Spastic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0524587 BXGD009232 Mean Corpuscular Volume (result)
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751748 BXGD010573 Nonketotic Hyperglycinemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0855790 BXGD011088 Decreased mean corpuscular volume
C1261502 BXGD011856 Finding of Mean Corpuscular Hemoglobin
C1835993 BXGD014068 Loss of ability to walk in early childhood
C1836830 BXGD014165 Developmental regression Mental Disorders
C1839888 BXGD014424 Decreased activity of the pyruvate dehydrogenase complex
C1848701 BXGD014967 Elevated hepatic transaminase
C1849156 BXGD015017 Spastic Ataxia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1859520 BXGD015907 Progressive spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2673914 BXGD017232 Anemia, Sideroblastic, Pyridoxine-Refractory, Autosomal Recessive Hemic and Lymphatic Diseases
C2698117 BXGD017446 Anisocyte Measurement
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4022891 BXGD021028 Elevated hepatic iron concentration
C4225155 BXGD022161 ANEMIA, SIDEROBLASTIC, 3, PYRIDOXINE-REFRACTORY
C4225178 BXGD022168 Childhood-onset spasticity with hyperglycinemia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C4225425 BXGD022275 ANEMIA, SIDEROBLASTIC, 2, PYRIDOXINE-REFRACTORY
C4551511 BXGD023330 X-linked sideroblastic anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552810 BXGD023525 Irritability, CTCAE
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000989 Glutathione 307.32
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein