Showing entry for Spastic Paraplegia


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Disease Information
BXGD IdBXGD002703
Disease NameSpastic Paraplegia
Disease CUI IdC0037772
MeSH Codes C23   C10  
Disease Class NamePathological Conditions, Signs and Symptoms; Nervous System Diseases
Semantic TypeDisease or Syndrome
Human Phenotype Ontology Id HP:0000707   HP:0003011  
Human Phenotype Ontology TermAbnormality of the nervous system; Abnormality of the musculature
Disease Ontology Id   
Disease Ontology Class Name
Disorder Network disorder-protein-compound-food associations
The  disease-related  target proteins
Proteins
Uniport Id BXGT Id Protein Name Gene Status Protein Class
Uniport Id BXGT Id Protein name Gene Status Protein class
O00189 BXGT003891 AP-4 complex subunit mu-1 9179 reviewed Extracellular structure
O00330 BXGT003910 Pyruvate dehydrogenase protein X component, mitochondrial 8050 reviewed Enzyme
O00429 BXGT003919 Dynamin-1-like protein 10059 reviewed Enzyme modulator
O00522 BXGT003935 Krev interaction trapped protein 1 889 reviewed
O43424 BXGT004592 Glutamate receptor ionotropic, delta-2 2895 reviewed Ion channel
O43896 BXGT004632 Kinesin-like protein KIF1C 10749 reviewed Cellular structure
O60313 BXGT004871 Dynamin-like 120 kDa protein, mitochondrial 4976 reviewed Enzyme modulator
O95255 BXGT005363 Multidrug resistance-associated protein 6 368 reviewed Transporter
O95363 BXGT005375 Phenylalanine--tRNA ligase, mitochondrial 10667 reviewed Enzyme
O95831 BXGT005399 Apoptosis-inducing factor 1, mitochondrial 9131 reviewed Enzyme
P00533 BXGT005575 Epidermal growth factor receptor 1956 reviewed Kinase
P05089 BXGT006310 Arginase-1 383 reviewed Enzyme
P07101 BXGT006547 Tyrosine 3-monooxygenase 7054 reviewed
P07384 BXGT006619 Calpain-1 catalytic subunit 823 reviewed Enzyme
P09936 BXGT006943 Ubiquitin carboxyl-terminal hydrolase isozyme L1 7345 reviewed Enzyme
P0DP23 BXGT007520 Calmodulin-1 808 reviewed
P0DP24 BXGT007521 Calmodulin-2 808 reviewed
P10809 BXGT007617 60 kDa heat shock protein, mitochondrial 3329 reviewed
P11166 BXGT007661 Solute carrier family 2, facilitated glucose transporter member 1 6513 reviewed Transporter
P20807 BXGT008601 Calpain-3 825 reviewed Enzyme
P30044 BXGT009395 Peroxiredoxin-5, mitochondrial 25824 reviewed
P30793 BXGT009466 GTP cyclohydrolase 1 2643 reviewed Enzyme
P32004 BXGT009594 Neural cell adhesion molecule L1 3897 reviewed
P36021 BXGT009893 Monocarboxylate transporter 8 6567 reviewed Transporter
P41229 BXGT010239 Lysine-specific demethylase 5C 8242 reviewed
P46100 BXGT010508 Transcriptional regulator ATRX 546 reviewed
P48643 BXGT010650 T-complex protein 1 subunit epsilon 22948 reviewed Chaperone
P49768 BXGT010740 Presenilin-1 5663 reviewed Enzyme
P49902 BXGT010758 Cytosolic purine 5'-nucleotidase 22978 reviewed Enzyme
P53355 BXGT010985 Death-associated protein kinase 1 1612 reviewed Kinase
P54762 BXGT011076 Ephrin type-B receptor 1 2047 reviewed Kinase
P54803 BXGT011082 Galactocerebrosidase 2581 reviewed
P54886 BXGT011092 Delta-1-pyrroline-5-carboxylate synthase 5832 reviewed Enzyme
P55072 BXGT011103 Transitional endoplasmic reticulum ATPase 7415 reviewed
Q01668 BXGT012605 Voltage-dependent L-type calcium channel subunit alpha-1D 776 reviewed Ion channel
Q04446 BXGT012764 1,4-alpha-glucan-branching enzyme 2632 reviewed Enzyme
Q12756 BXGT013261 Kinesin-like protein KIF1A 547 reviewed Cellular structure
Q12840 BXGT013269 Kinesin heavy chain isoform 5A 3798 reviewed Cellular structure
Q14204 BXGT013456 Cytoplasmic dynein 1 heavy chain 1 1778 reviewed Enzyme
Q16881 BXGT013688 Thioredoxin reductase 1, cytoplasmic 7296 reviewed Enzyme
Q6XUX3 BXGT016612 Dual serine/threonine and tyrosine protein kinase 25778 reviewed Kinase
Q86SX6 BXGT017601 Glutaredoxin-related protein 5, mitochondrial 51218 reviewed Enzyme
Q8TAF3 BXGT018786 WD repeat-containing protein 48 57599 reviewed
Q8TD30 BXGT018805 Alanine aminotransferase 2 84706 reviewed Enzyme
Q8WXF7 BXGT019011 Atlastin-1 51062 reviewed Enzyme modulator
Q96GD0 BXGT019665 Pyridoxal phosphate phosphatase 57026 reviewed Enzyme
Q9BX59 BXGT020157 Tapasin-related protein 55080 reviewed Receptor
Q9HCG7 BXGT020533 Non-lysosomal glucosylceramidase 57704 reviewed
Q9NZ09 BXGT021267 Ubiquitin-associated protein 1 51271 reviewed
Q9NZJ4 BXGT021274 Sacsin 26278 reviewed
Q9Y5Y6 BXGT022308 Suppressor of tumorigenicity 14 protein 6768 reviewed Enzyme
Q9Y619 BXGT022316 Mitochondrial ornithine transporter 1 10166 reviewed Transporter
Q7Z624 BXGT022792 Calmodulin-lysine N-methyltransferase 79823 reviewed
Q9UBP0 BXGT023601 Spastin 6683 reviewed Cellular structure
O95140 BXGT024482 Mitofusin-2 9927 reviewed Enzyme
P0DP25 BXGT024595 Calmodulin-3 808 reviewed
Q9UNE7 BXGT025000 E3 ubiquitin-protein ligase CHIP 10273 reviewed
P28715 BXGT025675 DNA repair protein complementing XP-G cells 2073 reviewed
The  disease-related  compounds
Compounds
BXGC Id Compound Name Structure Molecular Weight Number of targets?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease
The  disease-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compounds in food?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease