Showing entry for Beta-klotho


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT017639
Protein NameBeta-klotho
Uniport IdQ86Z14
GeneKLB
Gene Id152831
DomainGlyco_hydro_1
Pfam PF00232  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0008543 fibroblast growth factor receptor signaling pathway
Biological Process GO:0000165 MAPK cascade
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
Biological Process GO:0051897 positive regulation of protein kinase B signaling
molecular function GO:0017134 fibroblast growth factor binding
molecular function GO:0005104 fibroblast growth factor receptor binding
molecular function GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
cellular component GO:0005783 endoplasmic reticulum
cellular component GO:0016021 integral component of membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-109704 PI3K Cascade
R-HSA-112399 IRS-mediated signalling
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1307965 betaKlotho-mediated ligand binding
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-168256 Immune System
R-HSA-190236 Signaling by FGFR
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-2428924 IGF1R signaling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654716 Downstream signaling of activated FGFR4
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5654743 Signaling by FGFR4
R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5683057 MAPK family signaling cascades
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-74752 Signaling by Insulin receptor
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-9607240 FLT3 Signaling
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001948 BXGD000091 Alcohol consumption Behavior and Behavior Mechanisms
C0005845 BXGD000341 Blood urea nitrogen measurement
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011991 BXGD000766 Diarrhea Pathological Conditions, Signs and Symptoms
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0022104 BXGD001529 Irritable Bowel Syndrome Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029928 BXGD002183 Ovarian Diseases Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0035078 BXGD002505 Kidney Failure Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0085207 BXGD003140 Gestational Diabetes Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0202239 BXGD004087 Uric acid measurement (procedure)
C0206682 BXGD004237 Follicular thyroid carcinoma Neoplasms
C0220748 BXGD004336 Cartilage-hair hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Digestive System Diseases; Musculoskeletal Diseases; Immune System Diseases
C0236734 BXGD004823 Caffeine related disorders
C0238461 BXGD004936 Anaplastic thyroid carcinoma Neoplasms
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0260037 BXGD005227 Multiple tumors Neoplasms
C0268318 BXGD005896 Cholestasis of pregnancy Digestive System Diseases; Female Urogenital Diseases and Pregnancy Complications
C0342642 BXGD007519 Autosomal dominant hypophosphatemic rickets Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases
C0342649 BXGD007522 Vascular calcification Nutritional and Metabolic Diseases
C0348898 BXGD007884 Irritable bowel syndrome with diarrhea Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0863194 BXGD011276 Hepatoma resectable Digestive System Diseases; Neoplasms
C1134719 BXGD011688 Invasive Ductal Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1262211 BXGD011876 Diarrhoea predominant irritable bowel syndrome
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1704272 BXGD013537 Benign Prostatic Hyperplasia Male Urogenital Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2607914 BXGD017148 Allergic rhinitis (disorder) Respiratory Tract Diseases; Immune System Diseases; Otorhinolaryngologic Diseases
C2711227 BXGD017478 Steatohepatitis Digestive System Diseases
C3241937 BXGD018578 Nonalcoholic Steatohepatitis Digestive System Diseases
C3539878 BXGD019087 Triple Negative Breast Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C3899503 BXGD020084 Congenital hypogonadotropic hypogonadism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Endocrine System Diseases
C4722518 BXGD023806 Triple-Negative Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005620 beta-D-Glucopyranose 180.16
BXGC0030612 tetraethylene glycol 194.12
BXGC0050194 alpha-D-Mannose 180.06
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein