Showing entry for Retinol dehydrogenase 12


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT019701
Protein NameRetinol dehydrogenase 12
Uniport IdQ96NR8
GeneRDH12
Gene Id145226
Domainadh_short
Pfam PF00106  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.8 Metabolism of cofactors and vitamins hsa00830 Retinol metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0110095 cellular detoxification of aldehyde
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0007601 visual perception
molecular function GO:0052650 NADP-retinol dehydrogenase activity
molecular function GO:0004745 retinol dehydrogenase activity
cellular component GO:0005789 endoplasmic reticulum membrane
cellular component GO:0001917 photoreceptor inner segment
cellular component GO:0060342 photoreceptor inner segment membrane
Reactome
Pathway Id Pathway Name
R-HSA-162582 Signal Transduction
R-HSA-1643685 Disease
R-HSA-2187338 Visual phototransduction
R-HSA-2453864 Retinoid cycle disease events
R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-2474795 Diseases associated with visual transduction
R-HSA-372790 Signaling by GPCR
R-HSA-388396 GPCR downstream signalling
R-HSA-418594 G alpha (i) signalling events
R-HSA-9675143 Diseases of the neuronal system
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0014065 BXGD000884 Congenital cerebral hernia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0017601 BXGD001125 Glaucoma Eye Diseases
C0018777 BXGD001217 Conductive hearing loss Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0020459 BXGD001394 Hyperinsulinism Nutritional and Metabolic Diseases
C0020619 BXGD001447 Hypogonadism Endocrine System Diseases
C0022578 BXGD001557 Keratoconus Eye Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0029089 BXGD002107 Ophthalmoplegia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0035304 BXGD002528 Retinal Degeneration Eye Diseases
C0035309 BXGD002530 Retinal Diseases Eye Diseases
C0035334 BXGD002539 Retinitis Pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0266435 BXGD005668 Congenital hypoplasia of penis Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0311338 BXGD006878 Fundus Albipunctatus Eye Diseases
C0339525 BXGD007258 Autosomal dominant retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339526 BXGD007259 Autosomal recessive retinitis pigmentosa Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0339527 BXGD007260 Leber Congenital Amaurosis Eye Diseases
C0375206 BXGD007973 Hemiplegia/hemiparesis
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0476397 BXGD008991 Electroretinogram abnormal
C0557874 BXGD009444 Global developmental delay
C0854723 BXGD011026 Retinal Dystrophies Eye Diseases
C1288283 BXGD012175 Atrophoderma maculatum Skin and Connective Tissue Diseases
C1301509 BXGD012294 Severe visual impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C1384666 BXGD012948 hearing impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1840077 BXGD014434 Anteverted nostril
C1849367 BXGD015046 Nasal bridge wide
C1855676 BXGD015528 Aplasia/Hypoplasia of the cerebellar vermis
C1858080 BXGD015768 Retinal Dystrophy, Early Onset Severe Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2675186 BXGD017277 LEBER CONGENITAL AMAUROSIS 13 Eye Diseases
C2931258 BXGD017991 Amaurosis congenita of Leber, type 1 Eye Diseases
C3150208 BXGD018298 RETINITIS PIGMENTOSA 53
C3489532 BXGD018934 Cone-Rod Dystrophy 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3808249 BXGD019541 Abnormality of the optic disc
C4021786 BXGD020779 Atypical scarring of skin Pathological Conditions, Signs and Symptoms
C4024818 BXGD021428 Progressive night blindness Eye Diseases
C4085590 BXGD022119 Cone-Rod Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4316870 BXGD022707 Abnormality of the eye
C4551633 BXGD023378 Pigmentary retinal dystrophy Eye Diseases
C4551714 BXGD023398 Rod-Cone Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4703503 BXGD023654 Mild hypermetropia Eye Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0047568 Retinol 286.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein