Showing entry for Sentrin-specific protease 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT021292
Protein NameSentrin-specific protease 1
Uniport IdQ9P0U3
GeneSENP1
Gene Id29843
DomainPeptidase_C48
Pfam PF02902  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0016926 protein desumoylation
Biological Process GO:0016925 protein sumoylation
Biological Process GO:0006508 proteolysis
Biological Process GO:0010724 regulation of definitive erythrocyte differentiation
molecular function GO:0004175 endopeptidase activity
molecular function GO:0070140 SUMO-specific isopeptidase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005925 focal adhesion
cellular component GO:0031965 nuclear membrane
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-2990846 SUMOylation
R-HSA-3065679 SUMO is proteolytically processed
R-HSA-3215018 Processing and activation of SUMO
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0003850 BXGD000225 Arteriosclerosis Cardiovascular Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007134 BXGD000443 Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0007222 BXGD000454 Cardiovascular Diseases Cardiovascular Diseases
C0010054 BXGD000647 Coronary Arteriosclerosis Cardiovascular Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0019348 BXGD001325 Herpes Simplex Infections Infections; Skin and Connective Tissue Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023524 BXGD001681 Leukoencephalopathy, Progressive Multifocal Infections; Nervous System Diseases
C0023860 BXGD001708 Listeriosis Infections
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0025322 BXGD001863 Premature Menopause Female Urogenital Diseases and Pregnancy Complications
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0042834 BXGD003004 Vital capacity
C0085215 BXGD003141 Ovarian Failure, Premature Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0151744 BXGD003469 Myocardial Ischemia Cardiovascular Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205851 BXGD004132 Germ cell tumor Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0271650 BXGD006227 Impaired glucose tolerance Nutritional and Metabolic Diseases
C0272139 BXGD006309 Erythrocytosis due to low atmospheric pressure Hemic and Lymphatic Diseases
C0274294 BXGD006367 Chronic mountain sickness Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0278764 BXGD006581 Adult Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0278879 BXGD006610 Childhood Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0282612 BXGD006820 Prostatic Intraepithelial Neoplasias Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0520679 BXGD009101 Sleep Apnea, Obstructive Respiratory Tract Diseases; Nervous System Diseases
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0936223 BXGD011477 Metastatic Prostate Carcinoma Neoplasms; Male Urogenital Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1168327 BXGD011787 High-Grade Prostatic Intraepithelial Neoplasia Neoplasms; Male Urogenital Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1282496 BXGD012147 Metastasis from malignant tumor of prostate
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1335302 BXGD012775 Pancreatic Ductal Adenocarcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1739135 BXGD013733 Progression of prostate cancer
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1853195 BXGD015313 Prostate Cancer, Hereditary, 7 Neoplasms; Male Urogenital Diseases
C1956346 BXGD016627 Coronary Artery Disease Cardiovascular Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4528257 BXGD023159 Corpuscular Hemoglobin Concentration Mean
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0027644 2-(3,4-Dihydroxyphenyl)-5-Hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyloxan-2-Yl]Oxymethyl]Oxan-2-Yl]Oxychromen-4-One 594.16
BXGC0028823 (2R,3R,4S,5S,6R)-2-[[(1S,2R,3R)-7-Hydroxy-1-(4-Hydroxy-3,5-Dimethoxyphenyl)-3-(Hydroxymethyl)-6,8-Dimethoxy-1,2,3,4-Tetrahydronaphthalen-2-Yl]Methoxy]-6-(Hydroxymethyl)Oxane-3,4,5-Triol 582.23
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein