Showing entry for Voltage-dependent calcium channel gamma-2 subunit


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT022323
Protein NameVoltage-dependent calcium channel gamma-2 subunit
Uniport IdQ9Y698
GeneCACNG2
Gene Id10369
DomainPMP22_Claudin
Pfam PF00822  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04010 MAPK signaling pathway
5. Organismal Systems 5.3 Circulatory system hsa04260 Cardiac muscle contraction
5. Organismal Systems 5.3 Circulatory system hsa04261 Adrenergic signaling in cardiomyocytes
5. Organismal Systems 5.2 Endocrine system hsa04921 Oxytocin signaling pathway
6. Human Diseases 6.6 Cardiovascular diseases hsa05410 Hypertrophic cardiomyopathy (HCM)
6. Human Diseases 6.6 Cardiovascular diseases hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
6. Human Diseases 6.6 Cardiovascular diseases hsa05414 Dilated cardiomyopathy (DCM)
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0061337 cardiac conduction
Biological Process GO:0060082 eye blink reflex
Biological Process GO:0051899 membrane depolarization
Biological Process GO:0060081 membrane hyperpolarization
Biological Process GO:0007528 neuromuscular junction development
Biological Process GO:0099590 neurotransmitter receptor internalization
Biological Process GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome
Biological Process GO:2000969 positive regulation of AMPA receptor activity
Biological Process GO:1904510 positive regulation of protein localization to basolateral plasma membrane
Biological Process GO:0051968 positive regulation of synaptic transmission, glutamatergic
Biological Process GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:2000311 regulation of AMPA receptor activity
Biological Process GO:0051592 response to calcium ion
Biological Process GO:0019226 transmission of nerve impulse
molecular function GO:0016247 channel regulator activity
molecular function GO:0035255 ionotropic glutamate receptor binding
molecular function GO:0005245 voltage-gated calcium channel activity
cellular component GO:0032281 AMPA glutamate receptor complex
cellular component GO:0009986 cell surface
cellular component GO:0044300 cerebellar mossy fiber
cellular component GO:0005829 cytosol
cellular component GO:0030666 endocytic vesicle membrane
cellular component GO:0098978 glutamatergic synapse
cellular component GO:0099061 integral component of postsynaptic density membrane
cellular component GO:0005886 plasma membrane
cellular component GO:0098839 postsynaptic density membrane
cellular component GO:0098685 Schaffer collateral - CA1 synapse
cellular component GO:0036477 somatodendritic compartment
cellular component GO:0005891 voltage-gated calcium channel complex
Reactome
Pathway Id Pathway Name
R-HSA-112308 Presynaptic depolarization and calcium channel opening
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-1266738 Developmental Biology
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-5682910 LGI-ADAM interactions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0005586 BXGD000315 Bipolar Disorder Mental Disorders
C0006012 BXGD000360 Borderline Personality Disorder Mental Disorders
C0006111 BXGD000369 Brain Diseases Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006287 BXGD000390 Bronchopulmonary Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0014553 BXGD000931 Absence Epilepsy Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0027404 BXGD001984 Narcolepsy Nervous System Diseases; Mental Disorders
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0041671 BXGD002930 Attention Deficit Disorder Mental Disorders
C0150055 BXGD003401 Chronic pain Pathological Conditions, Signs and Symptoms
C0234251 BXGD004645 Inflammatory pain Pathological Conditions, Signs and Symptoms
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0279583 BXGD006640 Childhood T Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C1263846 BXGD011897 Attention deficit hyperactivity disorder Mental Disorders
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1963674 BXGD016692 Spinocerebellar Ataxia 10 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3280284 BXGD018819 MENTAL RETARDATION, AUTOSOMAL DOMINANT 10
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000434 Ethanol 46.07
BXGC0003611 Latex 416.57
BXGC0006372 Ergocalciferol 396.65
BXGC0024988 Nifedipine 346.12
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein