adisease

Showing entry for Inflammatory pain

General Disease Information
BXGD Id	BXGD004645
Disease Name	Inflammatory pain
Disease CUI Id	C0234251
MeSH Codes	C23
Disease Class Name	Pathological Conditions, Signs and Symptoms
Semantic Type	Sign or Symptom
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O00329	BXGT003909	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	5293	reviewed	Kinase
O14684	BXGT004082	Prostaglandin E synthase	9536	reviewed
O15054	BXGT004121	Lysine-specific demethylase 6B	23135	reviewed	Epigenetic regulator
O43612	BXGT004605	Orexin	3060	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60760	BXGT004899	Hematopoietic prostaglandin D synthase	27306	reviewed
O75116	BXGT005100	Rho-associated protein kinase 2	9475	reviewed	Kinase
O75311	BXGT005109	Glycine receptor subunit alpha-3	8001	reviewed	Ion channel
O75347	BXGT005113	Tubulin-specific chaperone A	6902	reviewed	Chaperone
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75475	BXGT005130	PC4 and SFRS1-interacting protein	11168	reviewed	Signaling
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01042	BXGT005722	Kininogen-1	3827	reviewed	Enzyme modulator
P01100	BXGT005727	Proto-oncogene c-Fos	2353	reviewed	Transcription factor
P01138	BXGT005738	Beta-nerve growth factor	4803	reviewed	Signaling
P01189	BXGT005742	Pro-opiomelanocortin	5443	reviewed
P01303	BXGT005748	Pro-neuropeptide Y	4852	reviewed	Signaling
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P01889	BXGT005809	HLA class I histocompatibility antigen, B-7 alpha chain	3106	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P04083	BXGT006147	Annexin A1	301	reviewed
P04629	BXGT006239	High affinity nerve growth factor receptor	4914	reviewed	Kinase
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05067	BXGT006306	Amyloid-beta precursor protein	351	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P06280	BXGT006433	Alpha-galactosidase A	2717	reviewed
P06702	BXGT006476	Protein S100-A9	6280	reviewed	Calcium-binding protein
P06850	BXGT006511	Corticoliberin	1392	reviewed	Signaling
P07101	BXGT006547	Tyrosine 3-monooxygenase	7054	reviewed
P07333	BXGT006602	Macrophage colony-stimulating factor 1 receptor	1436	reviewed	Kinase
P08908	BXGT006837	5-hydroxytryptamine receptor 1A	3350	reviewed	G-protein coupled receptor
P08922	BXGT006843	Proto-oncogene tyrosine-protein kinase ROS	6098	reviewed	Kinase
P09429	BXGT006889	High mobility group protein B1	3146	reviewed	Nucleic acid binding
P09601	BXGT006909	Heme oxygenase 1	3162	reviewed
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11511	BXGT007717	Aromatase	1588	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P14784	BXGT008054	Interleukin-2 receptor subunit beta	3560	reviewed	Receptor
P15085	BXGT008077	Carboxypeptidase A1	1357	reviewed	Enzyme
P15559	BXGT008139	NAD(P)H dehydrogenase [quinone] 1	1728	reviewed
P16157	BXGT008203	Ankyrin-1	286	reviewed
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P18089	BXGT008379	Alpha-2B adrenergic receptor	151	reviewed	G-protein coupled receptor
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P21554	BXGT008662	Cannabinoid receptor 1	1268	reviewed	G-protein coupled receptor
P21964	BXGT008714	Catechol O-methyltransferase	1312	reviewed	Enzyme
P23560	BXGT008883	Brain-derived neurotrophic factor	627	reviewed	Signaling
P23946	BXGT008932	Chymase	1215	reviewed	Enzyme
P25098	BXGT009015	Beta-adrenergic receptor kinase 1	156	reviewed	Kinase
P25100	BXGT009017	Alpha-1D adrenergic receptor	146	reviewed	G-protein coupled receptor
P25101	BXGT009018	Endothelin-1 receptor	1909	reviewed	G-protein coupled receptor
P25774	BXGT009066	Cathepsin S	1520	reviewed	Enzyme
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P27695	BXGT009199	DNA-(apurinic or apyrimidinic site) lyase	328	reviewed
P28347	BXGT009257	Transcriptional enhancer factor TEF-1	7003	reviewed	Transcription factor
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29323	BXGT009334	Ephrin type-B receptor 2	2048	reviewed	Kinase
P29350	BXGT009335	Tyrosine-protein phosphatase non-receptor type 6	5777	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31391	BXGT009535	Somatostatin receptor type 4	6754	reviewed	G-protein coupled receptor
P32239	BXGT009612	Gastrin/cholecystokinin type B receptor	887	reviewed	G-protein coupled receptor
P34932	BXGT009772	Heat shock 70 kDa protein 4	3308	reviewed
P34972	BXGT009779	Cannabinoid receptor 2	1269	reviewed	G-protein coupled receptor
P35219	BXGT009797	Carbonic anhydrase-related protein	767	reviewed
P35228	BXGT009800	Nitric oxide synthase, inducible	4843	reviewed
P35270	BXGT009807	Sepiapterin reductase	6697	reviewed
P35348	BXGT009814	Alpha-1A adrenergic receptor	148	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35372	BXGT009823	Mu-type opioid receptor	4988	reviewed	G-protein coupled receptor
P35408	BXGT009828	Prostaglandin E2 receptor EP4 subtype	5734	reviewed	G-protein coupled receptor
P36551	BXGT009927	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial	1371	reviewed	Enzyme
P37288	BXGT009977	Vasopressin V1a receptor	552	reviewed	G-protein coupled receptor
P40926	BXGT010207	Malate dehydrogenase, mitochondrial	4191	reviewed	Enzyme
P41143	BXGT010223	Delta-type opioid receptor	4985	reviewed	G-protein coupled receptor
P41146	BXGT010226	Nociceptin receptor	4987	reviewed	G-protein coupled receptor
P41594	BXGT010266	Metabotropic glutamate receptor 5	2915	reviewed	G-protein coupled receptor
P41597	BXGT010268	C-C chemokine receptor type 2	729230	reviewed
P42261	BXGT010293	Glutamate receptor 1	2890	reviewed	Ion channel
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P42338	BXGT010303	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	5291	reviewed	Kinase
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P43115	BXGT010356	Prostaglandin E2 receptor EP3 subtype	5733	reviewed	G-protein coupled receptor
P45974	BXGT010493	Ubiquitin carboxyl-terminal hydrolase 5	8078	reviewed	Enzyme
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P46663	BXGT010531	B1 bradykinin receptor	623	reviewed	G-protein coupled receptor
P48067	BXGT010619	Sodium- and chloride-dependent glycine transporter 1	6536	reviewed	Transporter
P48357	BXGT010627	Leptin receptor	3953	reviewed	Signaling
P48643	BXGT010650	T-complex protein 1 subunit epsilon	22948	reviewed	Chaperone
P48736	BXGT010658	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	5294	reviewed	Kinase
P49902	BXGT010758	Cytosolic purine 5'-nucleotidase	22978	reviewed	Enzyme
P51149	BXGT010835	Ras-related protein Rab-7a	7879	reviewed
P53985	BXGT011022	Monocarboxylate transporter 1	6566	reviewed	Transporter
P54829	BXGT011085	Tyrosine-protein phosphatase non-receptor type 5	84867	reviewed
P55055	BXGT011101	Oxysterols receptor LXR-beta	7376	reviewed	Nuclear receptor
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P56373	BXGT011164	P2X purinoceptor 3	5024	reviewed	Ion channel
P56524	BXGT011176	Histone deacetylase 4	9759	reviewed	Epigenetic regulator
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
Q00535	BXGT012534	Cyclin-dependent-like kinase 5	1020	reviewed	Kinase
Q01469	BXGT012590	Fatty acid-binding protein 5	2171	reviewed
Q01726	BXGT012610	Melanocyte-stimulating hormone receptor	4157	reviewed	G-protein coupled receptor
Q02790	BXGT012672	Peptidyl-prolyl cis-trans isomerase FKBP4	2288	reviewed	Enzyme
Q04609	BXGT012768	Glutamate carboxypeptidase 2	2346	reviewed	Enzyme
Q05586	BXGT012826	Glutamate receptor ionotropic, NMDA 1	2902	reviewed	Ion channel
Q08257	BXGT012975	Quinone oxidoreductase	1429	reviewed
Q08499	BXGT012988	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	5144	reviewed
Q12879	BXGT013275	Glutamate receptor ionotropic, NMDA 2A	2903	reviewed	Ion channel
Q13085	BXGT013309	Acetyl-CoA carboxylase 1	31	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13224	BXGT013328	Glutamate receptor ionotropic, NMDA 2B	2904	reviewed	Ion channel
Q13451	BXGT013356	Peptidyl-prolyl cis-trans isomerase FKBP5	2289	reviewed	Enzyme
Q13976	BXGT013409	cGMP-dependent protein kinase 1	5592	reviewed	Kinase
Q14833	BXGT013508	Metabotropic glutamate receptor 4	2914	reviewed	G-protein coupled receptor
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q53H47	BXGT015014	Histone-lysine N-methyltransferase SETMAR	6419	reviewed	Epigenetic regulator
Q7Z2W7	BXGT017248	Transient receptor potential cation channel subfamily M member 8	79054	reviewed	Ion channel
Q8IVS2	BXGT018349	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial	27349	reviewed
Q8NER1	BXGT018556	Transient receptor potential cation channel subfamily V member 1	7442	reviewed	Ion channel
Q92945	BXGT019397	Far upstream element-binding protein 2	8570	reviewed	Enzyme
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96FJ2	BXGT019659	Dynein light chain 2, cytoplasmic	140735	reviewed	Cellular structure
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q96PU5	BXGT019711	E3 ubiquitin-protein ligase NEDD4-like	23327	reviewed	Enzyme
Q99523	BXGT019929	Sortilin	6272	reviewed	Transporter
Q99572	BXGT019935	P2X purinoceptor 7	5027	reviewed	Ion channel
Q99685	BXGT019948	Monoglyceride lipase	11343	reviewed	Enzyme
Q99720	BXGT019955	Sigma non-opioid intracellular receptor 1	10280	reviewed
Q9BYT8	BXGT020190	Neurolysin, mitochondrial	57486	reviewed	Enzyme
Q9H244	BXGT020448	P2Y purinoceptor 12	64805	reviewed	G-protein coupled receptor
Q9H2X9	BXGT020459	Solute carrier family 12 member 5	57468	reviewed	Transporter
Q9H3N8	BXGT020463	Histamine H4 receptor	59340	reviewed	G-protein coupled receptor
Q9HBA0	BXGT020516	Transient receptor potential cation channel subfamily V member 4	59341	reviewed	Ion channel
Q9UBB5	BXGT021649	Methyl-CpG-binding domain protein 2	8932	reviewed	Epigenetic regulator
Q9UBL9	BXGT021656	P2X purinoceptor 2	22953	reviewed	Ion channel
Q9UEU0	BXGT021673	Vesicle transport through interaction with t-SNAREs homolog 1B	10490	reviewed	Transporter
Q9UHC3	BXGT021695	Acid-sensing ion channel 3	9311	reviewed	Ion channel
Q9UL51	BXGT021754	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	610	reviewed	Ion channel
Q9ULC4	BXGT021757	Malignant T-cell-amplified sequence 1	28985	reviewed	Receptor
Q9UNW8	BXGT021793	Probable G-protein coupled receptor 132	29933	reviewed	G-protein coupled receptor
Q9UQL6	BXGT021813	Histone deacetylase 5	10014	reviewed	Epigenetic regulator
Q9Y286	BXGT022225	Sialic acid-binding Ig-like lectin 7	27036	reviewed	Receptor
Q9Y2T6	BXGT022247	G-protein coupled receptor 55	9290	reviewed	G-protein coupled receptor
Q9Y2W7	BXGT022250	Calsenilin	30818	reviewed	Ion channel
Q9Y4D2	BXGT022274	Sn1-specific diacylglycerol lipase alpha	747	reviewed
Q9Y5S8	BXGT022302	NADPH oxidase 1	27035	reviewed
Q9Y698	BXGT022323	Voltage-dependent calcium channel gamma-2 subunit	10369	reviewed	Ion channel
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
Q15878	BXGT022659	Voltage-dependent R-type calcium channel subunit alpha-1E	777	reviewed	Ion channel
O60936	BXGT022857	Nucleolar protein 3	8996	reviewed
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}