Showing entry for NEDD4-like E3 ubiquitin-protein ligase WWP2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT023349
Protein NameNEDD4-like E3 ubiquitin-protein ligase WWP2
Uniport IdO00308
GeneWWP2
Gene Id11060
DomainHECT; WW
Pfam PF00632   PF00397  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
2. Genetic Information Processing 2.3 Folding, sorting and degradation hsa04120 Ubiquitin mediated proteolysis
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006464 cellular protein modification process
Biological Process GO:0006858 extracellular transport
Biological Process GO:0043433 negative regulation of DNA-binding transcription factor activity
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0045746 negative regulation of Notch signaling pathway
Biological Process GO:0051224 negative regulation of protein transport
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0032410 negative regulation of transporter activity
Biological Process GO:0045732 positive regulation of protein catabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0051865 protein autoubiquitination
Biological Process GO:0070534 protein K63-linked ubiquitination
Biological Process GO:0000209 protein polyubiquitination
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0034765 regulation of ion transmembrane transport
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:1901016 regulation of potassium ion transmembrane transporter activity
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process
Biological Process GO:0046718 viral entry into host cell
molecular function GO:0001085 RNA polymerase II transcription factor binding
molecular function GO:0008134 transcription factor binding
molecular function GO:0061630 ubiquitin protein ligase activity
molecular function GO:0004842 ubiquitin-protein transferase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
cellular component GO:0016020 membrane
cellular component GO:0005634 nucleus
cellular component GO:0000151 ubiquitin ligase complex
Reactome
Pathway Id Pathway Name
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-157118 Signaling by NOTCH
R-HSA-162582 Signal Transduction
R-HSA-6807070 PTEN Regulation
R-HSA-8948751 Regulation of PTEN stability and activity
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-9012852 Signaling by NOTCH3
R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000768 BXGD000007 Congenital Abnormality Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0005890 BXGD000345 Body Height
C0006413 BXGD000397 Burkitt Lymphoma Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007302 BXGD000460 Cartilage Diseases Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0017638 BXGD001132 Glioma Neoplasms
C0017654 BXGD001136 Glomerular Filtration Rate
C0021704 BXGD001510 Intelligence Behavior and Behavior Mechanisms
C0023508 BXGD001675 White Blood Cell Count procedure
C0024301 BXGD001759 Lymphoma, Follicular Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0027051 BXGD001963 Myocardial Infarction Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0039685 BXGD002825 Tetralogy of Fallot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0042834 BXGD003004 Vital capacity
C0079731 BXGD003087 B-Cell Lymphomas Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0149756 BXGD003358 Fasciitis, Plantar Musculoskeletal Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0158360 BXGD003883 Fibromatosis, Plantar Neoplasms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0200638 BXGD004043 Eosinophil count procedure
C0202236 BXGD004086 Triglycerides measurement
C0205682 BXGD004105 Waist-Hip Ratio
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0239946 BXGD005010 Fibrosis, Liver Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0424621 BXGD008536 Body Fat Distribution
C0428883 BXGD008639 Diastolic blood pressure
C0521158 BXGD009130 Recurrent tumor
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0596887 BXGD009648 mathematical ability
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0871470 BXGD011316 Systolic Pressure
C0919267 BXGD011426 ovarian neoplasm Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1140680 BXGD011718 Malignant neoplasm of ovary Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1314691 BXGD012388 Age at menarche Behavior and Behavior Mechanisms
C1397307 BXGD012996 Cardiac fibrosis
C1832661 BXGD013866 ANOPHTHALMIA AND PULMONARY HYPOPLASIA Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C2985280 BXGD018223 Blood Protein Measurement
C2986665 BXGD018237 Early-Stage Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3665419 BXGD019285 intracranial glioma Neoplasms; Nervous System Diseases
C3714636 BXGD019421 Pneumonitis Infections; Respiratory Tract Diseases
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4733214 BXGD023914 stage IIIC melanoma
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0003705 Chloride 35.45
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein