adisease

Showing entry for Cardiac fibrosis

General Disease Information
BXGD Id	BXGD012996
Disease Name	Cardiac fibrosis
Disease CUI Id	C1397307
MeSH Codes
Disease Class Name
Semantic Type	Disease or Syndrome
Human Phenotype Ontology Id
Human Phenotype Ontology Term
Disease Ontology Id
Disease Ontology Class Name
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O15123	BXGT004130	Angiopoietin-2	285	reviewed	Signaling
O15527	BXGT004176	N-glycosylase/DNA lyase	4968	reviewed
O60603	BXGT004887	Toll-like receptor 2	7097	reviewed
O60885	BXGT004906	Bromodomain-containing protein 4	23476	reviewed	Epigenetic regulator
O75030	BXGT005096	Microphthalmia-associated transcription factor	4286	reviewed
O75469	BXGT005128	Nuclear receptor subfamily 1 group I member 2	8856	reviewed	Nuclear receptor
O75762	BXGT005151	Transient receptor potential cation channel subfamily A member 1	8989	reviewed	Ion channel
O95069	BXGT005348	Potassium channel subfamily K member 2	3776	reviewed	Ion channel
O95255	BXGT005363	Multidrug resistance-associated protein 6	368	reviewed	Transporter
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00747	BXGT005639	Plasminogen	5340	reviewed	Enzyme
P00749	BXGT005641	Urokinase-type plasminogen activator	5328	reviewed	Enzyme
P00797	BXGT005658	Renin	5972	reviewed	Enzyme
P01019	BXGT005717	Angiotensinogen	183	reviewed	Enzyme modulator
P01031	BXGT005720	Complement C5	727	reviewed	Enzyme modulator
P01137	BXGT005737	Transforming growth factor beta-1 proprotein	7040	reviewed	Signaling
P01275	BXGT005747	Glucagon	2641	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P01579	BXGT005770	Interferon gamma	3458	reviewed
P01584	BXGT005772	Interleukin-1 beta	3553	reviewed
P02452	BXGT005878	Collagen alpha-1(I) chain	1277	reviewed
P02741	BXGT005936	C-reactive protein	1401	reviewed
P02750	BXGT005942	Leucine-rich alpha-2-glycoprotein	116844	reviewed
P02751	BXGT005943	Fibronectin	2335	reviewed	Signaling
P02766	BXGT005953	Transthyretin	7276	reviewed	Transporter
P04150	BXGT006154	Glucocorticoid receptor	2908	reviewed	Nuclear receptor
P04798	BXGT006265	Cytochrome P450 1A1	1543	reviewed	Enzyme
P04839	BXGT006273	Cytochrome b-245 heavy chain	1536	reviewed	Ion channel
P05091	BXGT006312	Aldehyde dehydrogenase, mitochondrial	217	reviewed	Enzyme
P05121	BXGT006320	Plasminogen activator inhibitor 1	5054	reviewed	Enzyme modulator
P05231	BXGT006345	Interleukin-6	3569	reviewed
P06396	BXGT006435	Gelsolin	2934	reviewed	Cellular structure
P06870	BXGT006518	Kallikrein-1	3816	reviewed	Enzyme
P08235	BXGT006751	Mineralocorticoid receptor	4306	reviewed	Nuclear receptor
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08588	BXGT006795	Beta-1 adrenergic receptor	153	reviewed	G-protein coupled receptor
P08670	BXGT006810	Vimentin	7431	reviewed
P09237	BXGT006874	Matrilysin	4316	reviewed	Enzyme
P09619	BXGT006911	Platelet-derived growth factor receptor beta	5159	reviewed	Kinase
P09874	BXGT006934	Poly [ADP-ribose] polymerase 1	142	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P12821	BXGT007849	Angiotensin-converting enzyme	1636	reviewed	Enzyme
P13500	BXGT007916	C-C motif chemokine 2	6347	reviewed	Signaling
P13726	BXGT007950	Tissue factor	2152	reviewed	Receptor
P14174	BXGT007991	Macrophage migration inhibitory factor	4282	reviewed
P14210	BXGT007994	Hepatocyte growth factor	3082	reviewed	Enzyme
P14780	BXGT008053	Matrix metalloproteinase-9	4318	reviewed	Enzyme
P14921	BXGT008068	Protein C-ets-1	2113	reviewed	Transcription factor
P15692	BXGT008147	Vascular endothelial growth factor A	7422	reviewed	Signaling
P16050	BXGT008184	Arachidonate 15-lipoxygenase	246	reviewed	Enzyme
P16070	BXGT008186	CD44 antigen	960	reviewed
P17301	BXGT008299	Integrin alpha-2	3673	reviewed
P17405	BXGT008304	Sphingomyelin phosphodiesterase	6609	reviewed	Enzyme
P17676	BXGT008327	CCAAT/enhancer-binding protein beta	1051	reviewed	Transcription factor
P17931	BXGT008356	Galectin-3	3958	reviewed	Signaling
P18847	BXGT008431	Cyclic AMP-dependent transcription factor ATF-3	467	reviewed	Transcription factor
P19099	BXGT008456	Cytochrome P450 11B2, mitochondrial	1585	reviewed
P19438	BXGT008480	Tumor necrosis factor receptor superfamily member 1A	7132	reviewed
P21333	BXGT008638	Filamin-A	2316	reviewed
P21453	BXGT008654	Sphingosine 1-phosphate receptor 1	1901	reviewed	G-protein coupled receptor
P21730	BXGT008687	C5a anaphylatoxin chemotactic receptor 1	728	reviewed	G-protein coupled receptor
P21980	BXGT008715	Protein-glutamine gamma-glutamyltransferase 2	7052	reviewed	Enzyme
P22736	BXGT008800	Nuclear receptor subfamily 4 group A member 1	3164	reviewed	Nuclear receptor
P25103	BXGT009020	Substance-P receptor	6869	reviewed	G-protein coupled receptor
P25963	BXGT009080	NF-kappa-B inhibitor alpha	4792	reviewed
P26447	BXGT009114	Protein S100-A4	6275	reviewed	Calcium-binding protein
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P27487	BXGT009187	Dipeptidyl peptidase 4	1803	reviewed	Enzyme
P28068	BXGT009229	HLA class II histocompatibility antigen, DM beta chain	3109	reviewed	Immune response
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P28562	BXGT009270	Dual specificity protein phosphatase 1	1843	reviewed
P28845	BXGT009297	Corticosteroid 11-beta-dehydrogenase isozyme 1	3290	reviewed
P29474	BXGT009352	Nitric oxide synthase, endothelial	4846	reviewed
P30556	BXGT009441	Type-1 angiotensin II receptor	185	reviewed	G-protein coupled receptor
P31639	BXGT009556	Sodium/glucose cotransporter 2	6524	reviewed	Transporter
P31645	BXGT009558	Sodium-dependent serotonin transporter	6532	reviewed	Transporter
P34947	BXGT009774	G protein-coupled receptor kinase 5	2869	reviewed	Kinase
P35222	BXGT009799	Catenin beta-1	1499	reviewed
P35555	BXGT009845	Fibrillin-1	2200	reviewed	Calcium-binding protein
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P36896	BXGT009940	Activin receptor type-1B	91	reviewed	Kinase
P36897	BXGT009941	TGF-beta receptor type-1	7046	reviewed	Kinase
P37023	BXGT009953	Serine/threonine-protein kinase receptor R3	94	reviewed	Kinase
P37173	BXGT009970	TGF-beta receptor type-2	7048	reviewed	Kinase
P37231	BXGT009972	Peroxisome proliferator-activated receptor gamma	5468	reviewed	Nuclear receptor
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P41235	BXGT010241	Hepatocyte nuclear factor 4-alpha	3172	reviewed	Nuclear receptor
P42345	BXGT010304	Serine/threonine-protein kinase mTOR	2475	reviewed	Kinase
P45983	BXGT010494	Mitogen-activated protein kinase 8	5599	reviewed	Kinase
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P49588	BXGT010713	Alanine--tRNA ligase, cytoplasmic	16	reviewed	Nucleic acid binding
P49841	BXGT010750	Glycogen synthase kinase-3 beta	2932	reviewed	Kinase
P51884	BXGT010903	Lumican	4060	reviewed
P55085	BXGT011104	Proteinase-activated receptor 2	2150	reviewed	G-protein coupled receptor
P60484	BXGT011307	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	5728	reviewed	Enzyme
P60709	BXGT011322	Actin, cytoplasmic 1	60	reviewed	Cellular structure
P61073	BXGT011352	C-X-C chemokine receptor type 4	7852	reviewed	G-protein coupled receptor
P61769	BXGT011383	Beta-2-microglobulin	567	reviewed	Immune response
P63165	BXGT011506	Small ubiquitin-related modifier 1	7341	reviewed
P78317	BXGT011831	E3 ubiquitin-protein ligase RNF4	6047	reviewed
P78556	BXGT011849	C-C motif chemokine 20	6364	reviewed	Signaling
P84022	BXGT012027	Mothers against decapentaplegic homolog 3	4088	reviewed	Transcription factor
Q00613	BXGT012540	Heat shock factor protein 1	3297	reviewed	Transcription factor
Q00987	BXGT012559	E3 ubiquitin-protein ligase Mdm2	4193	reviewed	Nucleic acid binding
Q03181	BXGT012701	Peroxisome proliferator-activated receptor delta	5467	reviewed	Nuclear receptor
Q04721	BXGT012777	Neurogenic locus notch homolog protein 2	4853	reviewed
Q05397	BXGT012815	Focal adhesion kinase 1	5747	reviewed	Kinase
Q05655	BXGT012832	Protein kinase C delta type	5580	reviewed	Kinase
Q07108	BXGT012919	Early activation antigen CD69	969	reviewed
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q08050	BXGT012958	Forkhead box protein M1	2305	reviewed
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13315	BXGT013339	Serine-protein kinase ATM	472	reviewed	Kinase
Q13427	BXGT013354	Peptidyl-prolyl cis-trans isomerase G	9360	reviewed
Q13526	BXGT013369	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5300	reviewed
Q13547	BXGT013373	Histone deacetylase 1	3065	reviewed	Epigenetic regulator
Q14118	BXGT013444	Dystroglycan	1605	reviewed	Receptor
Q14393	BXGT013466	Growth arrest-specific protein 6	2621	reviewed	Extracellular structure
Q14524	BXGT013478	Sodium channel protein type 5 subunit alpha	6331	reviewed	Ion channel
Q14790	BXGT013505	Caspase-8	841	reviewed	Enzyme
Q15063	BXGT013531	Periostin	10631	reviewed	Signaling
Q15109	BXGT013537	Advanced glycosylation end product-specific receptor	177	reviewed	Receptor
Q15796	BXGT013599	Mothers against decapentaplegic homolog 2	4087	reviewed	Transcription factor
Q16236	BXGT013624	Nuclear factor erythroid 2-related factor 2	4780	reviewed	Enzyme
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q16637	BXGT013646	Survival motor neuron protein	6607	reviewed	Epigenetic regulator
Q16698	BXGT013659	2,4-dienoyl-CoA reductase, mitochondrial	1666	reviewed	Enzyme
Q16832	BXGT013678	Discoidin domain-containing receptor 2	4921	reviewed	Kinase
Q5JTZ9	BXGT015458	Alanine--tRNA ligase, mitochondrial	57505	reviewed	Nucleic acid binding
Q8NBS9	BXGT018543	Thioredoxin domain-containing protein 5	81567	reviewed
Q8NET8	BXGT018557	Transient receptor potential cation channel subfamily V member 3	162514	reviewed	Ion channel
Q92736	BXGT019367	Ryanodine receptor 2	6262	reviewed	Ion channel
Q92963	BXGT019401	GTP-binding protein Rit1	6016	reviewed	Enzyme modulator
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q96F46	BXGT019656	Interleukin-17 receptor A	23765	reviewed
Q96P20	BXGT019704	NACHT, LRR and PYD domains-containing protein 3	114548	reviewed
Q9BYF1	BXGT020186	Angiotensin-converting enzyme 2	59272	reviewed	Enzyme
Q9HBX9	BXGT020523	Relaxin receptor 1	59350	reviewed	G-protein coupled receptor
Q9HC29	BXGT020526	Nucleotide-binding oligomerization domain-containing protein 2	64127	reviewed	Enzyme
Q9NPH5	BXGT021159	NADPH oxidase 4	50507	reviewed	Enzyme
Q9NTG7	BXGT021211	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	23410	reviewed	Epigenetic regulator
Q9UHV8	BXGT021706	Galactoside-binding soluble lectin 13	29124	reviewed	Signaling
Q9UKV0	BXGT021750	Histone deacetylase 9	9734	reviewed	Epigenetic regulator
Q9Y4K0	BXGT022280	Lysyl oxidase homolog 2	4017	reviewed
Q9Y5S8	BXGT022302	NADPH oxidase 1	27035	reviewed
Q9Y6K1	BXGT022331	DNA (cytosine-5)-methyltransferase 3A	1788	reviewed
Q92847	BXGT022673	Growth hormone secretagogue receptor type 1	2693	reviewed	G-protein coupled receptor
Q9UK05	BXGT023094	Growth/differentiation factor 2	2658	reviewed	Signaling
O14793	BXGT023280	Growth/differentiation factor 8	2660	reviewed	Signaling
O00308	BXGT023349	NEDD4-like E3 ubiquitin-protein ligase WWP2	11060	reviewed	Enzyme
Q9HAU4	BXGT024040	E3 ubiquitin-protein ligase SMURF2	64750	reviewed	Enzyme
O95399	BXGT024237	Urotensin-2	10911	reviewed
P29590	BXGT024350	Protein PML	5371	reviewed
O95140	BXGT024482	Mitofusin-2	9927	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}