Showing entry for Deoxyhypusine synthase


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT025175
Protein NameDeoxyhypusine synthase
Uniport IdP49366
GeneDHPS
Gene Id1725
DomainDS
Pfam PF01916  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0042102 positive regulation of T cell proliferation
Biological Process GO:0046203 spermidine catabolic process
Biological Process GO:0008216 spermidine metabolic process
Biological Process GO:0006412 translation
molecular function GO:0034038 deoxyhypusine synthase activity
molecular function GO:0042802 identical protein binding
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
Reactome
Pathway Id Pathway Name
R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-204626 Hypusine synthesis from eIF5A-lysine
R-HSA-392499 Metabolism of proteins
R-HSA-597592 Post-translational protein modification
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001175 BXGD000029 Acquired Immunodeficiency Syndrome Infections; Immune System Diseases
C0004623 BXGD000282 Bacterial Infections Infections
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006271 BXGD000384 Bronchiolitis Infections; Respiratory Tract Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0009806 BXGD000633 Constipation Pathological Conditions, Signs and Symptoms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0020649 BXGD001459 Hypotension Cardiovascular Diseases
C0024115 BXGD001732 Lung diseases Respiratory Tract Diseases
C0024530 BXGD001783 Malaria Infections
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025303 BXGD001858 Meningococcal Infections Infections
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0031873 BXGD002311 Pica Disease Pathological Conditions, Signs and Symptoms; Mental Disorders
C0032285 BXGD002344 Pneumonia Infections; Respiratory Tract Diseases
C0032914 BXGD002379 Pre-Eclampsia Female Urogenital Diseases and Pregnancy Complications
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0079924 BXGD003103 Oligohydramnios Female Urogenital Diseases and Pregnancy Complications
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0231686 BXGD004508 Gait, Unsteady Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0233514 BXGD004584 Abnormal behavior Behavior and Behavior Mechanisms
C0239234 BXGD004974 Low set ears
C0240635 BXGD005047 Byzanthine arch palate Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Stomatognathic Diseases
C0241726 BXGD005110 Delayed ability to walk
C0242510 BXGD005173 Drug usage Chemically-Induced Disorders; Mental Disorders
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0280100 BXGD006713 Solid Neoplasm Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0423224 BXGD008475 Sunken eyes Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0424503 BXGD008532 Dysmorphic facies
C0426848 BXGD008590 Sacral dimple Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0431128 BXGD008664 Papillary craniopharyngioma Neoplasms
C0557874 BXGD009444 Global developmental delay
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0677936 BXGD009737 Refractory cancer Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0852413 BXGD010943 Abnormal muscle tone Nervous System Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1535939 BXGD013323 Pneumocystis jiroveci pneumonia Infections; Respiratory Tract Diseases
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1838391 BXGD014313 Limb hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1853743 BXGD015358 Muscular hypotonia of the trunk Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854113 BXGD015382 Prominent nasal bridge
C2363741 BXGD017100 HIV-1 infection
C2747816 BXGD017577 Complicated malaria Infections
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3854222 BXGD019826 Human immunodeficiency virus (HIV) II infection category B1
C4021817 BXGD020803 Abnormality of head or neck
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4553743 BXGD023548 Spasticity, CTCAE
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000985 Putrescine 88.15
BXGC0002390 Spermine 202.34
BXGC0004139 Sperminidine 145.25
BXGC0006368 Formic acid 46.03
BXGC0037687 (4S)-2-methylpentane-2,4-diol 118.1
BXGC0049447 acetate 59.01
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein