Showing entry for Altenusin


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0017701
Compound NameAltenusin
Structure
FormulaC15H14O6
InchiKeyADPBTBPPIIKLEH-UHFFFAOYSA-N
SMILESCOc1cc(O)c(c(c1)c1cc(O)c(cc1C)O)C(=O)O
InchiInChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20)
IUPAC2-(4,5-dihydroxy-2-methylphenyl)-6-hydroxy-4-methoxybenzoic acid
Molecular Weight290.08
Pubchem Id6918469
Chembl IdCHEMBL483531
Targets of Information Source
DrugBank n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
PDB n.a
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Binding DB 50576
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 - 4147.647397 - -
reviewed BXGT022194 Zinc finger protein mex-5 reviewed mex-5 - - - 300000
reviewed BXGT007701 Glucose-6-phosphate 1-dehydrogenase reviewed Enzyme G6PD - 31000 - -
CHEMBL CHEMBL483531
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
O94925 BXGT005342 Glutaminase kidney isoform, mitochondrial reviewed Enzyme GLS Potency - 35481 nM
Q9UBT6 BXGT021664 DNA polymerase kappa reviewed - POLK Potency - 56234 nM
Q9BHT9 BXGT020096 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase unreviewed - G6PD-6PGL IC50 '=' 19400 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 10000 nM
P54760 BXGT011075 Ephrin type-B receptor 4 reviewed Kinase EPHB4 IC50 '=' 9 ug.mL-1
Q9UIF8 BXGT021718 Bromodomain adjacent to zinc finger domain protein 2B reviewed - BAZ2B Potency - 56234 nM
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 IC50 '=' 7 ug.mL-1
O75496 BXGT005132 Geminin reviewed - GMNN Potency - 9200 nM
O14965 BXGT004117 Aurora kinase A reviewed Kinase AURKA IC50 '=' 1 ug.mL-1
Q92830 BXGT019379 Histone acetyltransferase KAT2A reviewed - KAT2A Potency - 7079 nM
P15056 BXGT008075 Serine/threonine-protein kinase B-raf reviewed Kinase BRAF IC50 '=' 3 ug.mL-1
G5EF15 BXGT003524 Cytoplasmic zinc-finger protein unreviewed - pos-1 EC50 '=' 30968 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 25118 nM
B2RXH2 BXGT002006 Lysine-specific demethylase 4E reviewed - KDM4E Potency '=' 14125 nM
O60285 BXGT004867 NUAK family SNF1-like kinase 1 reviewed Kinase NUAK1 IC50 '=' 6 ug.mL-1
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed - KDM4A Potency - 12589 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency - 44668 nM
P00533 BXGT005575 Epidermal growth factor receptor reviewed Kinase EGFR IC50 '=' 9 ug.mL-1
P68400 BXGT011599 Casein kinase II subunit alpha reviewed Kinase CSNK2A1 IC50 '>' 10 ug.mL-1
O00444 BXGT003921 Serine/threonine-protein kinase PLK4 reviewed Kinase PLK4 IC50 '=' 3 ug.mL-1
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 22387 nM
P46063 BXGT010501 ATP-dependent DNA helicase Q1 reviewed Enzyme RECQL Potency '=' 39810 nM
P39748 BXGT010134 Flap endonuclease 1 reviewed Enzyme FEN1 Potency - 89125 nM
Q9Y253 BXGT022216 DNA polymerase eta reviewed - POLH Potency - 84921 nM
P41279 BXGT010254 Mitogen-activated protein kinase kinase kinase 8 reviewed Kinase MAP3K8 IC50 '=' 8 ug.mL-1
Q962Y6 BXGT019597 Thioredoxin glutathione reductase unreviewed - TGR Potency '=' 158 nM
Q9XUB2 BXGT022194 Zinc finger protein mex-5 reviewed - mex-5 EC50 '>' 300000 nM
P09619 BXGT006911 Platelet-derived growth factor receptor beta reviewed Kinase PDGFRB IC50 '=' 5 ug.mL-1
P04626 BXGT006238 Receptor tyrosine-protein kinase erbB-2 reviewed Kinase ERBB2 IC50 '>' 10 ug.mL-1
P12931 BXGT007859 Proto-oncogene tyrosine-protein kinase Src reviewed Kinase SRC IC50 '=' 8 ug.mL-1
P31749 BXGT009574 RAC-alpha serine/threonine-protein kinase reviewed Kinase AKT1 IC50 '>' 10 ug.mL-1
P08069 BXGT006723 Insulin-like growth factor 1 receptor reviewed Kinase IGF1R IC50 '=' 4 ug.mL-1
P53350 BXGT010984 Serine/threonine-protein kinase PLK1 reviewed Kinase PLK1 Potency - 23778 nM
Q9BHT9 BXGT020096 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase unreviewed - G6PD-6PGL IC50 '>' 80000 nM
Q9BHT9 BXGT020096 Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase unreviewed - G6PD-6PGL IC50 '=' 3750 nM
Q07820 BXGT012942 Induced myeloid leukemia cell differentiation protein Mcl-1 reviewed Signaling MCL1 IC50 '=' 4147 nM
P08581 BXGT006794 Hepatocyte growth factor receptor reviewed Kinase MET IC50 '=' 4 ug.mL-1
Q13951 BXGT013407 Core-binding factor subunit beta reviewed - CBFB Potency - 25118 nM
Q01196 BXGT012575 Runt-related transcription factor 1 reviewed Transcription factor RUNX1 Potency - 25118 nM
P24941 BXGT009002 Cyclin-dependent kinase 2 reviewed Kinase CDK2 IC50 '>' 10 ug.mL-1
P24385 BXGT008965 G1/S-specific cyclin-D1 reviewed Enzyme modulator CCND1 IC50 '=' 4 ug.mL-1
P11802 BXGT007750 Cyclin-dependent kinase 4 reviewed Kinase CDK4 IC50 '=' 4 ug.mL-1
P10253 BXGT007550 Lysosomal alpha-glucosidase reviewed Enzyme GAA Potency '=' 15848 nM
Q96KQ7 BXGT019687 Histone-lysine N-methyltransferase EHMT2 reviewed Epigenetic regulator EHMT2 Potency - 354 nM
P35968 BXGT009887 Vascular endothelial growth factor receptor 2 reviewed Kinase KDR IC50 '=' 5 ug.mL-1
P36888 BXGT009938 Receptor-type tyrosine-protein kinase FLT3 reviewed Kinase FLT3 IC50 '=' 1 ug.mL-1
P35916 BXGT009881 Vascular endothelial growth factor receptor 3 reviewed Kinase FLT4 IC50 '>' 10 ug.mL-1
P06213 BXGT006425 Insulin receptor reviewed Kinase INSR IC50 '=' 5 ug.mL-1
Q27686 BXGT013930 Pyruvate kinase reviewed - PYK Potency '=' 2818 nM
Q57TT1 BXGT015153 Uncharacterized protein unreviewed - Tb927.8.6820 Potency - 10000 nM
P08659 BXGT006805 Luciferin 4-monooxygenase reviewed - Potency - 4775 nM
P63092 BXGT011495 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short reviewed - GNAS Potency - 50118 nM
Q05397 BXGT012815 Focal adhesion kinase 1 reviewed Kinase PTK2 IC50 '>' 10 ug.mL-1
Q96GD4 BXGT019667 Aurora kinase B reviewed Kinase AURKB IC50 '=' 1 ug.mL-1
O89049 BXGT005293 Thioredoxin reductase 1, cytoplasmic reviewed - Txnrd1 Potency - 794 nM
P11413 BXGT007701 Glucose-6-phosphate 1-dehydrogenase reviewed Enzyme G6PD IC50 '=' 31000 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 16360 nM
P06746 BXGT006496 DNA polymerase beta reviewed Enzyme POLB Potency '=' 19952 nM
Q9NUW8 BXGT021219 Tyrosyl-DNA phosphodiesterase 1 reviewed Enzyme TDP1 Potency - 4610 nM
Q02763 BXGT012667 Angiopoietin-1 receptor reviewed Kinase TEK IC50 '=' 9 ug.mL-1
P83916 BXGT012025 Chromobox protein homolog 1 reviewed Epigenetic regulator CBX1 Potency - 22387 nM
P10636 BXGT007596 Microtubule-associated protein tau reviewed - MAPT Potency '=' 28183 nM
P28482 BXGT009263 Mitogen-activated protein kinase 1 reviewed Kinase MAPK1 Potency '=' 15848 nM
O15648 BXGT004185 ATP-dependent 6-phosphofructokinase reviewed - pfk Potency - 37933 nM
P37840 BXGT010015 Alpha-synuclein reviewed Transporter SNCA Potency - 14125 nM
Q9UNA4 BXGT021785 DNA polymerase iota reviewed - POLI Potency - 44668 nM
P27695 BXGT009199 DNA-(apurinic or apyrimidinic site) lyase reviewed - APEX1 Potency - 19952 nM
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF02603 Sonneratia alba Sonneratia alba Human Edible Plant
BXGF05998 Vaccaria hispanica Vaccaria hispanica Medicinal Plant
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease