Showing entry for Serine/threonine-protein kinase PLK4


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT003921
Protein NameSerine/threonine-protein kinase PLK4
Uniport IdO00444
GenePLK4
Gene Id10733
DomainPkinase; Plk4_PB1; Plk4_PB2; POLO_box
Pfam PF00069   PF18190   PF18409   PF00659  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
3. Environmental Information Processing 3.2 Signal transduction hsa04068 FoxO signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007099 centriole replication
Biological Process GO:0097711 ciliary basal body-plasma membrane docking
Biological Process GO:0098535 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
Biological Process GO:0000086 G2/M transition of mitotic cell cycle
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0046601 positive regulation of centriole replication
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0032465 regulation of cytokinesis
Biological Process GO:0010389 regulation of G2/M transition of mitotic cell cycle
Biological Process GO:0060707 trophoblast giant cell differentiation
molecular function GO:0005524 ATP binding
molecular function GO:0042802 identical protein binding
molecular function GO:0004674 protein serine/threonine kinase activity
cellular component GO:0005814 centriole
cellular component GO:0005813 centrosome
cellular component GO:0032154 cleavage furrow
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0098536 deuterosome
cellular component GO:0005730 nucleolus
cellular component GO:0005634 nucleus
cellular component GO:0000922 spindle pole
cellular component GO:0001741 XY body
Reactome
Pathway Id Pathway Name
R-HSA-1640170 Cell Cycle
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380287 Centrosome maturation
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-5617833 Cilium Assembly
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-68877 Mitotic Prometaphase
R-HSA-68886 M Phase
R-HSA-69275 G2/M Transition
R-HSA-69278 Cell Cycle, Mitotic
R-HSA-8854518 AURKA Activation by TPX2
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0004509 BXGD000275 Azoospermia Male Urogenital Diseases
C0005684 BXGD000319 Malignant neoplasm of urinary bladder Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006625 BXGD000401 Cachexia Pathological Conditions, Signs and Symptoms
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010278 BXGD000660 Craniosynostosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0015398 BXGD000984 Eye Diseases, Hereditary Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017601 BXGD001125 Glaucoma Eye Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0020473 BXGD001396 Hyperlipidemia Nutritional and Metabolic Diseases
C0021400 BXGD001504 Influenza Infections; Respiratory Tract Diseases
C0022679 BXGD001575 Cystic kidney Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023449 BXGD001650 Acute lymphocytic leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452 BXGD001651 Childhood Acute Lymphoblastic Leukemia Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024299 BXGD001758 Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025149 BXGD001826 Medulloblastoma Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0025990 BXGD001884 Micrognathism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C0026010 BXGD001886 Microphthalmos Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0026826 BXGD001935 Muscle Hypertonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027654 BXGD002010 Embryonal Neoplasm Neoplasms
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0028738 BXGD002081 Nystagmus Eye Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0029463 BXGD002160 Osteosarcoma Neoplasms
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038379 BXGD002752 Strabismus Eye Diseases; Nervous System Diseases
C0086543 BXGD003294 Cataract Eye Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206743 BXGD004285 Rhabdoid Tumor Neoplasms
C0220630 BXGD004302 Adult Liver Carcinoma Digestive System Diseases; Neoplasms
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0240538 BXGD005041 Convex nasal ridge
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0265202 BXGD005461 Seckel syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0266544 BXGD005691 Microcornea Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0278510 BXGD006526 Childhood Medulloblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0279000 BXGD006622 Liver and Intrahepatic Biliary Tract Carcinoma Digestive System Diseases; Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0339383 BXGD007245 Choroidal and/or chorioretinal disorder Eye Diseases
C0342573 BXGD007508 PITUITARY DWARFISM I Musculoskeletal Diseases; Nervous System Diseases; Endocrine System Diseases
C0343401 BXGD007623 MRSA - Methicillin resistant Staphylococcus aureus infection Infections
C0345904 BXGD007745 Malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0400966 BXGD008266 Non-alcoholic Fatty Liver Disease Digestive System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0431350 BXGD008668 Primary microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0541764 BXGD009259 Delayed bone age
C0557874 BXGD009444 Global developmental delay
C0585442 BXGD009593 Osteosarcoma of bone Neoplasms
C0587248 BXGD009617 Costello syndrome (disorder) Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677886 BXGD009734 Epithelial ovarian cancer Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699791 BXGD009867 Stomach Carcinoma Digestive System Diseases; Neoplasms
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740279 BXGD009973 Cerebellar atrophy
C0751606 BXGD010523 Adult Acute Lymphocytic Leukemia
C0878787 BXGD011392 Growth failure
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1328407 BXGD012465 Hip Dysplasia Musculoskeletal Diseases; Wounds and Injuries
C1332206 BXGD012504 Adult Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1332979 BXGD012571 Childhood Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332986 BXGD012574 Childhood Osteosarcoma Neoplasms
C1384583 BXGD012942 Congenital absence of germinal epithelium of testes Male Urogenital Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1512409 BXGD013188 Hepatocarcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1837249 BXGD014210 Malformations of Cortical Development, Group II Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1837463 BXGD014235 Narrow face
C1840069 BXGD014433 Sandal gap
C1840077 BXGD014434 Anteverted nostril
C1844505 BXGD014633 Pointed chin
C1847540 BXGD014874 Azoospermia, Nonobstructive Male Urogenital Diseases
C1849364 BXGD015045 Absent earlobe
C1849367 BXGD015046 Nasal bridge wide
C1850049 BXGD015101 Clinodactyly of the 5th finger
C1854418 BXGD015402 Biparietal narrowing
C1855285 BXGD015483 Protruding ear
C1857042 BXGD015669 Sparse scalp hair
C1857656 BXGD015731 Prematurely aged appearance
C1857679 BXGD015735 Sloping forehead
C1862475 BXGD016132 Abnormality of retinal pigmentation
C1865037 BXGD016289 Cone-shaped epiphysis
C1956147 BXGD016622 Microlissencephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1961102 BXGD016673 Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1963184 BXGD016688 Nystagmus, CTCAE 3.0
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2675111 BXGD017272 Abnormal eyelash morphology
C2749675 BXGD017631 Cortical gyral simplification
C2919142 BXGD017867 Short Stature, CTCAE
C3279222 BXGD018751 Aplasia/Hypoplasia of the cerebellum
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3502492 BXGD019046 Microcephaly with Chorioretinopathy, Autosomal Recessive Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Musculoskeletal Diseases; Nervous System Diseases
C3553764 BXGD019187 Joint hyperflexibility
C3665347 BXGD019279 Visual Impairment Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3853041 BXGD019819 Severe Congenital Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C4012968 BXGD020124 Mild global developmental delay
C4015388 BXGD020203 MICROCEPHALY AND CHORIORETINOPATHY, AUTOSOMAL RECESSIVE, 2
C4021800 BXGD020790 Abnormality of dental enamel
C4024202 BXGD021303 Reduced number of teeth
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4551583 BXGD023361 Cerebral cortical atrophy
C4552766 BXGD023523 Miscarriage Female Urogenital Diseases and Pregnancy Complications
C4554036 BXGD023557 Nystagmus, CTCAE 5.0
C4721610 BXGD023760 Carcinoma, Ovarian Epithelial Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000933 (-)-Arctigenin 372.41
BXGC0001940 Daphnetin 178.14
BXGC0002063 Alternariol 258.23
BXGC0002071 Apigenin 270.24
BXGC0003705 Chloride 35.45
BXGC0004580 Carbanilide 212.25
BXGC0005624 Genistein 270.24
BXGC0005683 Quercetin 302.24
BXGC0006193 Ellagic acid 302.19
BXGC0007052 Olomoucine 298.34
BXGC0012706 4-hydroxy-5-nitrophenyl acetic acid 197.03
BXGC0013582 Curcumin 368.13
BXGC0017701 Altenusin 290.08
BXGC0020911 Debromohymenialdisine 245.09
BXGC0035685 alternariol monomethyl ether 272.07
BXGC0042376 Picropodophyllotoxin 414.13
BXGC0042870 Piceatannol 244.07
BXGC0044857 Sp-600125 220.06
BXGC0045254 Sb-202190 331.11
BXGC0047692 Gefitinib 446.15
BXGC0051819 Altertoxin I 352.09
BXGC0051995 Wedelolactone 314.04
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein