Showing entry for LIM domain-binding protein 3


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT005099
Protein NameLIM domain-binding protein 3
Uniport IdO75112
GeneLDB3
Gene Id11155
DomainDUF4749; LIM; PDZ
Pfam PF15936   PF00412   PF00595  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007507 heart development
Biological Process GO:0061061 muscle structure development
Biological Process GO:0045214 sarcomere organization
molecular function GO:0003779 actin binding
molecular function GO:0008092 cytoskeletal protein binding
molecular function GO:0046872 metal ion binding
molecular function GO:0051371 muscle alpha-actinin binding
molecular function GO:0005080 protein kinase C binding
cellular component GO:0005912 adherens junction
cellular component GO:0005856 cytoskeleton
cellular component GO:0031941 filamentous actin
cellular component GO:0048471 perinuclear region of cytoplasm
cellular component GO:0031143 pseudopodium
cellular component GO:0001725 stress fiber
cellular component GO:0030018 Z disc
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007194 BXGD000452 Hypertrophic Cardiomyopathy Cardiovascular Diseases
C0016529 BXGD001068 Forced expiratory volume function
C0018784 BXGD001220 Sensorineural Hearing Loss (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0018794 BXGD001222 Heart Block Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0018799 BXGD001224 Heart Diseases Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0026848 BXGD001941 Myopathy Musculoskeletal Diseases; Nervous System Diseases
C0026850 BXGD001942 Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027126 BXGD001976 Myotonic Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027127 BXGD001977 Myotonia Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0027868 BXGD002053 Neuromuscular Diseases Nervous System Diseases
C0152025 BXGD003521 Polyneuropathy Nervous System Diseases
C0231666 BXGD004505 Wrist-Drop Nervous System Diseases
C0240421 BXGD005037 Progressive muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0241005 BXGD005072 Creatine phosphokinase serum increased
C0242698 BXGD005189 Ventricular Dysfunction, Left Cardiovascular Diseases
C0340427 BXGD007329 Familial dilated cardiomyopathy Cardiovascular Diseases
C0349788 BXGD007956 Arrhythmogenic Right Ventricular Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C0427515 BXGD008619 Neutrophil abnormality
C0442874 BXGD008814 Neuropathy Nervous System Diseases
C0476403 BXGD008992 Electromyogram abnormal
C0544966 BXGD009320 Autophagic vaculoes (finding)
C0553980 BXGD009420 Endomyocardial Fibrosis Cardiovascular Diseases
C0574083 BXGD009501 3-Methylglutaconic aciduria type 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Cardiovascular Diseases
C0575081 BXGD009512 Gait abnormality Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0746674 BXGD010147 Generalized muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0751336 BXGD010392 Distal Muscular Dystrophies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0878544 BXGD011368 Cardiomyopathies Cardiovascular Diseases
C0917713 BXGD011404 Becker Muscular Dystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1292778 BXGD012237 Chronic myeloproliferative disorder Neoplasms; Hemic and Lymphatic Diseases
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1832244 BXGD013815 CARDIOMYOPATHY, DILATED, 1C (disorder) Cardiovascular Diseases
C1832370 BXGD013832 MYOPATHY, MYOFIBRILLAR, DESMIN-RELATED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Cardiovascular Diseases
C1832931 BXGD013885 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C1834536 BXGD013977 Weakness of the intrinsic hand muscles
C1834696 BXGD013989 Hyporeflexia of lower limbs
C1836057 BXGD014076 Muscle fiber splitting
C1836155 BXGD014084 Myopathy, Myofibrillar, Zasp-Related Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C1836156 BXGD014085 Progressive proximal muscle weakness
C1836609 BXGD014138 Progressive distal muscle weakness
C1837323 BXGD014220 Decreased Achilles reflex
C1858127 BXGD015775 Limb-girdle muscle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C1864716 BXGD016245 Intrinsic hand muscle atrophy
C1866012 BXGD016361 Proximal muscle weakness in upper limbs
C1866141 BXGD016379 Foot dorsiflexor weakness
C1960469 BXGD016664 Left ventricular noncompaction Cardiovascular Diseases
C2228039 BXGD016957 Ankle weakness Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C2678065 BXGD017398 Myofibrillar Myopathy Musculoskeletal Diseases; Nervous System Diseases
C2921627 BXGD017886 Clinically isolated syndrome
C3152137 BXGD018459 LEFT VENTRICULAR NONCOMPACTION 3
C3250443 BXGD018584 MYOTONIC DYSTROPHY 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C3277184 BXGD018709 Decreased patellar reflex
C4021133 BXGD020563 Left ventricular noncompaction cardiomyopathy Pathological Conditions, Signs and Symptoms
C4021726 BXGD020735 EMG: myopathic abnormalities Musculoskeletal Diseases; Nervous System Diseases
C4021727 BXGD020736 EMG: neuropathic changes
C4022585 BXGD020926 Fatigable weakness of distal limb muscles
C4024601 BXGD021334 Weakness of long finger extensor muscles
C4024610 BXGD021341 Leg muscle stiffness
C4225414 BXGD022270 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 24
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4551915 BXGD023441 Gait Disturbance, CTCAE
C4552811 BXGD023526 Generalized Muscle Weakness, CTCAE
C4721453 BXGD023744 Peripheral Nervous System Diseases Nervous System Diseases
C4721886 BXGD023780 MYOPATHY, MYOFIBRILLAR, 4
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0006162 L-Glutamic acid 147.13
BXGC0032575 Leucine 131.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein