Showing entry for Pyruvic Acid


　 　 　 　 　 　 　 　 　 　 　 　 　 　 　
General Compound Information
BXGC IdBXGC0038275
Compound NamePyruvic Acid
Structure
FormulaC3H4O3
InchiKeyLCTONWCANYUPML-UHFFFAOYSA-N
SMILESOC(=O)C(=O)C
InchiInChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
IUPAC2-oxopropanoic acid
Molecular Weight88.02
Pubchem Id1060
Chembl IdCHEMBL1162144
Targets of Information Source
DrugBank DB00119
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
Uniport Id BXGT Id Protein Name Status Protein Class Gene Groups Target Type
O15427 BXGT004167 Monocarboxylate transporter 4 reviewed Transporter SLC16A3 approved; investigational; nutraceutical -
P36021 BXGT009893 Monocarboxylate transporter 8 reviewed Transporter SLC16A2 approved; investigational; nutraceutical -
Q9BYV1 BXGT020191 Alanine--glyoxylate aminotransferase 2, mitochondrial reviewed - AGXT2 approved; investigational; nutraceutical -
O15375 BXGT004158 Monocarboxylate transporter 6 reviewed Transporter SLC16A5 approved; investigational; nutraceutical -
P30613 BXGT009447 Pyruvate kinase PKLR reviewed Kinase PKLR approved; investigational; nutraceutical -
O15403 BXGT004165 Monocarboxylate transporter 7 reviewed Transporter SLC16A6 approved; investigational; nutraceutical -
O60669 BXGT004891 Monocarboxylate transporter 2 reviewed Transporter SLC16A7 approved; investigational; nutraceutical -
P11177 BXGT007666 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial reviewed - PDHB approved; investigational; nutraceutical -
P14618 BXGT008027 Pyruvate kinase PKM reviewed Kinase PKM approved; investigational; nutraceutical -
P80404 BXGT011907 4-aminobutyrate aminotransferase, mitochondrial reviewed Enzyme ABAT approved; investigational; nutraceutical inhibitor
O15374 BXGT004157 Monocarboxylate transporter 5 reviewed Transporter SLC16A4 approved; investigational; nutraceutical -
O95907 BXGT005406 Monocarboxylate transporter 3 reviewed Transporter SLC16A8 approved; investigational; nutraceutical -
P53985 BXGT011022 Monocarboxylate transporter 1 reviewed Transporter SLC16A1 approved; investigational; nutraceutical -
P11498 BXGT007714 Pyruvate carboxylase, mitochondrial reviewed Enzyme PC approved; investigational; nutraceutical -
PDB PYR
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM Ka M-1
P22259 BXGT008748 Phosphoenolpyruvate carboxykinase (ATP) reviewed pckA - - - - -
P0A790 BXGT007100 Aspartate 1-decarboxylase reviewed panD - - - - -
P23522 BXGT008877 5-keto-4-deoxy-D-glucarate aldolase reviewed garL - - - - -
A0A140NB38 BXGT000660 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase unreviewed ECBD_1789 - - - - -
P11974 BXGT007764 Pyruvate kinase PKM reviewed PKM - - - - -
P9WKK7 BXGT012372 Isocitrate lyase reviewed icl - - - - -
P00175 BXGT005478 Cytochrome b2, mitochondrial reviewed CYB2 - - - - -
P0A6L4 BXGT007064 N-acetylneuraminate lyase reviewed nanA - - - - -
P09373 BXGT006881 Formate acetyltransferase 1 reviewed pflB - - - - -
P00862 BXGT005677 Histidine decarboxylase proenzyme reviewed hdcA - - - - -
P17707 BXGT008331 S-adenosylmethionine decarboxylase proenzyme reviewed AMD1 Enzyme - - - -
P00897 BXGT005686 Anthranilate synthase component 1 reviewed trpE - - - - -
P61889 BXGT011392 Malate dehydrogenase reviewed mdh - 56000000 - - -
P0A9G6 BXGT007187 Isocitrate lyase reviewed aceA - - - - -
Q9UVD4 BXGT021833 Macrophomate synthase unreviewed - - - - -
Q04694 BXGT012775 S-adenosylmethionine decarboxylase proenzyme reviewed SAMDC - - - - -
Q57764 BXGT015132 Pyruvoyl-dependent arginine decarboxylase reviewed pdaD - - - - -
Q56062 BXGT015077 2-methylisocitrate lyase reviewed prpB - - - - -
P37330 BXGT009978 Malate synthase G reviewed glcB - 1000000 - - -
P23368 BXGT008856 NAD-dependent malic enzyme, mitochondrial reviewed ME2 Enzyme - - - -
Q70AC7 BXGT016662 Methylmalonyl-CoA carboxyltransferase 5S subunit reviewed - - - - -
O52942 BXGT004695 Alanine dehydrogenase unreviewed ald - - - - -
Q5SKN7 BXGT015774 Aspartate 1-decarboxylase reviewed panD - - - - -
O54288 BXGT004723 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase reviewed - - - - -
Q9RW27 BXGT021523 NimA-related protein unreviewed DR_0842 - - - - -
Q9WXS1 BXGT021961 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase unreviewed TM_0066 - - - - -
P77541 BXGT011814 2-methylisocitrate lyase reviewed prpB - - - - -
A6VKV4 BXGT001513 Phosphoenolpyruvate carboxykinase (ATP) reviewed pckA - - - - -
P94692 BXGT012144 Pyruvate:ferredoxin oxidoreductase reviewed por - - - - -
Q44467 BXGT014606 Lactate oxidase unreviewed - - - - -
P37063 BXGT009959 Pyruvate oxidase reviewed pox5 - - - - -
Q9X9I8 BXGT022158 Salicylate synthetase, Irp9 unreviewed irp9 - - - - -
P9WFX1 BXGT012252 Salicylate synthase reviewed mbtI - - - - -
Q51507 BXGT014952 Isochorismate pyruvate lyase reviewed pchB - - - - -
Q3J1R2 BXGT014439 Alpha-keto acid-binding periplasmic protein TakP reviewed takP - - - 270 -
Q4JC35 BXGT014825 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase reviewed Saci_0225 - - - - -
P16528 BXGT008240 Transcriptional repressor IclR reviewed iclR - - - - -
P07379 BXGT006617 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] reviewed Pck1 - - - - -
Q704D1 BXGT016655 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase reviewed kdgA - - - - -
P9WQB1 BXGT012498 Alanine dehydrogenase reviewed ald - - - - -
P06169 BXGT006417 Pyruvate decarboxylase isozyme 1 reviewed PDC1 - - - - -
P76469 BXGT011787 2-keto-3-deoxy-L-rhamnonate aldolase reviewed rhmA - - - - -
P06672 BXGT006467 Pyruvate decarboxylase reviewed pdc - - - - -
Q8R7R4 BXGT018691 Phosphoenolpyruvate-protein phosphotransferase unreviewed PtsA - - - - -
Q97BK3 BXGT019791 NDP-sugar epimerase unreviewed TVG0440460 - 23200000 - - -
P11498 BXGT007714 Pyruvate carboxylase, mitochondrial reviewed PC Enzyme - - - -
A0A0H3JRU9 BXGT000419 Pyruvate carboxylase reviewed pycA - - - - -
Q8F3Q1 BXGT018124 Isopropylmalate/homocitrate/citramalate synthase reviewed cimA - - - - -
P00593 BXGT005594 Phospholipase A2 reviewed PLA2G1B - - - - -
Q9BHM6 BXGT020094 Octopine dehydrogenase reviewed odh1 - - - - -
Q5HJD7 BXGT015412 L-lactate dehydrogenase 1 reviewed ldh1 - - - - -
Q5HG25 BXGT015407 4-hydroxy-tetrahydrodipicolinate synthase reviewed dapA - - - - -
P21874 BXGT008702 Pyruvate dehydrogenase E1 component subunit beta reviewed pdhB - - - - -
P0A6L2 BXGT007063 4-hydroxy-tetrahydrodipicolinate synthase reviewed dapA - - - 29900 -
Q9WZC3 BXGT022021 S-adenosylmethionine decarboxylase proenzyme reviewed speH - - - - -
P9WP25 BXGT012437 4-hydroxy-tetrahydrodipicolinate synthase reviewed dapA - - - - -
P00341 BXGT005506 L-lactate dehydrogenase A chain reviewed ldha - - - - -
A5W059 BXGT001370 4-hydroxy-4-methyl-2-oxoglutarate aldolase/4-carboxy-4-hydroxy-2-oxoadipate aldolase reviewed Pput_1361 - - - - -
D4GTL2 BXGT002927 Malate synthase reviewed aceB - - - - -
Q9PIK3 BXGT021332 Aspartate 1-decarboxylase reviewed panD - - - - -
Q396C7 BXGT014378 Anthranilate/para-aminobenzoate synthase component I unreviewed Bcep18194_B1570 - - - - -
D0CFC3 BXGT002673 4-hydroxy-tetrahydrodipicolinate synthase unreviewed dapA - - - - -
P14618 BXGT008027 Pyruvate kinase PKM reviewed PKM Kinase - - - -
D2YW47 BXGT002865 putative Kdpg (2-keto-3-deoxy-6-phosphogluconate) aldolase unreviewed - - - - -
B1IS70 BXGT001883 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase reviewed hpcH - - - - -
B1IS70 BXGT001883 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase reviewed hpcH - - - 26900000 -
O54983 BXGT004739 Ketimine reductase mu-crystallin reviewed Crym - - - - -
Q8ZNT7 BXGT019225 D-cysteine desulfhydrase reviewed dcyD - - - - -
A0A0F6AW83 BXGT000177 Conjugative transfer: regulation unreviewed traJ - - - - -
Q87T87 BXGT017677 Methyl-accepting chemotaxis protein unreviewed VP0183 - - - - -
A0A0F7RI56 BXGT000211 Methylisocitrate lyase unreviewed prpB - - - - -
Q5H4T8 BXGT015393 Cystathionine gamma-lyase-like protein unreviewed metB - - - - -
O31671 BXGT004407 Sporulation kinase D reviewed kinD - - - - -
P25325 BXGT009038 3-mercaptopyruvate sulfurtransferase reviewed MPST Enzyme - - - -
Q643B8 BXGT016117 Uncharacterized protein unreviewed mppR - - - - -
Q2K340 BXGT014111 Pyruvate carboxylase unreviewed pyc - - - - -
P30615 BXGT009448 Pyruvate kinase 1 reviewed PYK1 - - - - -
D1A3K8 BXGT002777 4-hydroxy-2-oxovalerate aldolase unreviewed Tcur_0536 - - - - -
P37355 BXGT009984 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase reviewed menH - - - - -
Q5CYZ2 BXGT015314 Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase unreviewed cgd7_480 - - - - -
P75682 BXGT011751 Putative 2-dehydro-3-deoxy-D-gluconate aldolase YagE reviewed yagE - - - - -
Q48AL6 BXGT014753 Extracellular solute-binding protein, family 7 unreviewed CPS_0129 - - - - -
A0A075B5G8 BXGT000060 Lactate dehydrogenase unreviewed - - - - -
A0A075B5H0 BXGT000061 Malate dehydrogenase unreviewed - - - - -
Q3MFZ5 BXGT014504 Amino acid/amide ABC transporter substrate-binding protein, HAAT family unreviewed Ava_0465 - - - - -
D7C0E5 BXGT003000 Acetoacetate decarboxylase unreviewed SBI_00515 - - - - -
Q96XT2 BXGT019755 2-oxoacid:ferredoxin oxidoreductase 2, subunit alpha reviewed ST2435 - - - - -
Q8NMD2 BXGT018581 Dihydrodipicolinate synthase/N-acetylneuraminate lyase unreviewed Cgl2646 - - - - -
Q15TH9 BXGT013619 TRAP dicarboxylate transporter-DctP subunit unreviewed Patl_2292 - - - - -
Q9UGL1 BXGT021685 Lysine-specific demethylase 5B reviewed KDM5B Epigenetic regulator - - - -
O75164 BXGT005104 Lysine-specific demethylase 4A reviewed KDM4A - - - - -
Q94JQ4 BXGT019568 Reactive Intermediate Deaminase A, chloroplastic reviewed RIDA - - - - -
Q8UB77 BXGT018901 Probable 5-dehydro-4-deoxyglucarate dehydratase reviewed Atu3140 - - - - -
Q1H157 BXGT013790 Oxaloacetate decarboxylase alpha subunit unreviewed Mfla_1512 - - - - -
Q7YW97 BXGT017234 L-threonine 3-dehydrogenase unreviewed - - - - -
P22221 BXGT008743 Pyruvate, phosphate dikinase, chloroplastic reviewed PPDK - - - - -
Q587A7 BXGT015209 S-adenosylmethionine decarboxylase proenzyme unreviewed Tb927.6.4410 - - - - -
P39669 BXGT010129 Glucose-1-phosphate adenylyltransferase reviewed glgC - - - - -
P27696 BXGT009200 Acetolactate synthase, catabolic reviewed budB - - - - -
O52792 BXGT023675 4-hydroxymandelate oxidase reviewed hmo - - - - -
O25064 BXGT004240 Uncharacterized protein unreviewed HP_0291 - - - - -
P9WPE1 BXGT012451 Citrate lyase subunit beta-like protein reviewed citE - - - - -
P9WPE0 BXGT012450 Citrate lyase subunit beta-like protein reviewed citE - - - - -
P07342 BXGT006606 Acetolactate synthase catalytic subunit, mitochondrial reviewed ILV2 - - - - -
H8EVV4 BXGT003625 Isocitrate lyase 1 reviewed icl1 - - - - -
Q84LQ5 BXGT023812 Malic enzyme unreviewed SORBI_3003G036200 - - - - -
Q97U28 BXGT024132 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase reviewed eda - - - - -
Q8NLC0 BXGT024435 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase unreviewed Cgl3022 - - - - -
Q9I111 BXGT024438 FAA_hydrolase domain-containing protein unreviewed PA2471 - - - - -
S6C1Z0 BXGT024459 L-lactate dehydrogenase unreviewed ldh - - - - -
G2IPX5 BXGT024549 Uncharacterized protein unreviewed SLG_11280 - - - - -
B4SII9 BXGT024572 Cystathionine gamma-lyase unreviewed Smal_0489 - - - - -
P0A8K1 BXGT024728 Phosphatidylserine decarboxylase proenzyme reviewed psd - - - - -
P9WIL3 BXGT025146 Aspartate 1-decarboxylase reviewed panD - - - - -
Q8A5J2 BXGT017825 Putative ryanodine receptor unreviewed BT_2247 - - - - -
A0QX93 BXGT026043 Anthranilate synthase component 1 reviewed trpE - - - - -
Binding DB 19473
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
Uniport Id BXGT Id Protein Name Status Protein Class Gene Ki nM ic50 nM Kd nM EC50 nM
reviewed BXGT011178 C-terminal-binding protein 2 reviewed Transcription factor CTBP2 - >300000 - -
reviewed BXGT018912 Solute carrier family 22 member 6 reviewed Slc22a6 11900000 - - -
reviewed BXGT017282 Solute carrier family 22 member 20 reviewed Slc22a20 271000 - - -
reviewed BXGT019400 Solute carrier organic anion transporter family member 2A1 reviewed Transporter SLCO2A1 26000000 - - -
reviewed BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO reviewed FTO - >1000000 - -
CHEMBL CHEMBL1162144
Uniport Id BXGT Id Protein Name Status Protein Class Gene width="10%">Type Relation value Units
Uniport Id BXGT Id Protein Name Status Protein Class Gene Type Relation value Units
Q05BR4 BXGT012851 SLC16A10 protein unreviewed - SLC16A10 Activity - - -
Q80UJ1 BXGT017282 Solute carrier family 22 member 20 reviewed - Slc22a20 Ki '=' 269153 nM
Q66HS9 BXGT016172 Monocarboxylate transporter 2 unreviewed - Slc16a7 Ki '=' 80000 nM
Q80UJ1 BXGT017282 Solute carrier family 22 member 20 reviewed - Slc22a20 Ki '=' 271000 nM
Q8VC69 BXGT018912 Solute carrier family 22 member 6 reviewed - Slc22a6 Ki '=' 11900000 nM
P53987 BXGT011023 Monocarboxylate transporter 1 reviewed - Slc16a1 Km '=' 1010000 nM
P53987 BXGT011023 Monocarboxylate transporter 1 reviewed - Slc16a1 Activity '=' 23 %
P53987 BXGT011023 Monocarboxylate transporter 1 reviewed - Slc16a1 Km '=' 2500000 nM
Q91Y77 BXGT019323 Monocarboxylate transporter 10 reviewed - Slc16a10 Activity - - -
O60669 BXGT004891 Monocarboxylate transporter 2 reviewed Transporter SLC16A7 Km '=' 25000 nM
O15427 BXGT004167 Monocarboxylate transporter 4 reviewed Transporter SLC16A3 Km '=' 153000000 nM
P56545 BXGT011178 C-terminal-binding protein 2 reviewed Transcription factor CTBP2 IC50 '>' 300000 nM
Q92959 BXGT019400 Solute carrier organic anion transporter family member 2A1 reviewed Transporter SLCO2A1 Ki '=' 26000000 nM
Q9C0B1 BXGT020209 Alpha-ketoglutarate-dependent dioxygenase FTO reviewed - FTO IC50 '>' 1000000 nM
Q8VC69 BXGT018912 Solute carrier family 22 member 6 reviewed - Slc22a6 Ki '=' 12022644 nM
B2GV46 BXGT001957 Free fatty acid receptor 3 reviewed - Ffar3 EC50 - - -
Foods  containing  the  compound
Foods
BXGF Id Food Name Scientific Name Food Group
BXGF Id Food Name Scientific Name Food Group
BXGF00040 Pepper (C. annuum) Capsicum annuum Vegetables
BXGF00047 Chickpea Cicer arietinum Pulses
BXGF00956 Passiflora incarnata Passiflora incarnata Medicinal Plant
BXGF01157 Alstonia muelleriana Alstonia muelleriana Others
BXGF01185 Aloe vera Aloe vera Medicinal Plant
BXGF01205 Dacrydium cupressinum Dacrydium cupressinum Medicinal Plant
BXGF01442 Torilis japonica Torilis japonica Medicinal Plant
BXGF01448 Trigonella grandiflora Trigonella grandiflora Others
BXGF01554 Nicotiana undulata Nicotiana undulata Others
BXGF01821 Artemisia cina Artemisia cina Medicinal Plant
BXGF01900 Aloe ferox Aloe ferox Medicinal Plant
BXGF01911 Bupleurum scorzonerifolium Bupleurum scorzonerifolium Medicinal Plant
BXGF02065 Cnidium monnieri Cnidium monnieri Medicinal Plant
BXGF02317 Krameria parvifolia Krameria parvifolia Others
BXGF02372 Aesculus turbinata Aesculus turbinata Medicinal Plant
BXGF02390 Argyreia speciosa Argyreia speciosa Medicinal Plant
BXGF02465 Vernonia profuga Vernonia profuga Others
BXGF02567 Lycium chinense Lycium chinense Medicinal Plant
BXGF02578 Artocarpus styracifolius Artocarpus styracifolius Human Edible Plant
BXGF02757 Tripolium pannonicum Tripolium pannonicum Others
BXGF02779 Swertia chinensis Swertia chinensis Medicinal Plant
BXGF02821 Forsythia giraldiana Forsythia giraldiana Others
BXGF02892 Dorstenia mannii Dorstenia mannii Medicinal Plant
BXGF02925 Coreopsis nodosa Coreopsis nodosa Others
BXGF03180 Uvaria calamistrata Uvaria calamistrata Medicinal Plant
BXGF03508 Haematococcus lacustris Haematococcus lacustris Others
BXGF03560 Alnus alnobetula Alnus alnobetula Others
BXGF03645 Lycium barbarum Lycium barbarum Medicinal Plant
BXGF03685 Typha latifolia Typha latifolia Medicinal Plant
BXGF03847 Thermopsis mollis Thermopsis mollis Others
BXGF04430 Crinum latifolium Crinum latifolium Medicinal Plant
BXGF04631 Aloe spicata Aloe spicata Medicinal Plant
BXGF04820 Panax ginseng Panax ginseng 0
BXGF04875 Bupleurum chinense Bupleurum chinense Medicinal Plant
BXGF04926 Aloe africana Aloe africana Medicinal Plant
BXGF04981 Bupleurum falcatum Bupleurum falcatum Medicinal Plant
BXGF05073 Alnus cordata Alnus cordata Human Edible Plant
BXGF05162 Melia indica Melia indica Medicinal Plant
BXGF05308 Aloe deltoideodonta Aloe deltoideodonta Others
BXGF05413 Glycine tomentella Glycine tomentella Human Edible Plant
BXGF05501 Bauhinia purpurea Bauhinia purpurea Medicinal Plant
BXGF05817 Panax schinseng Panax schinseng Others
BXGF05819 Citrus aurantium Citrus aurantium Medicinal Plant
BXGF05944 Senecio paludaffinis Senecio paludaffinis Others
BXGF05960 Leitneria floridana Leitneria floridana Others
BXGF06124 Notholaena aschenborniana Notholaena aschenborniana Others
BXGF06128 Cnidium monieri Cnidium monieri Others
The  compound-realted  diseases
Diseases
BXGD Id Disease Name CUI Disease Id Disease Class Name Number of targets?Number of targets related to compound connecting disease, higher numbers indicate the compound is more associated with the disease