Showing entry for 4-aminobutyrate aminotransferase, mitochondrial


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT011907
Protein Name4-aminobutyrate aminotransferase, mitochondrial
Uniport IdP80404
GeneABAT
Gene Id18
DomainAminotran_3
Pfam PF00202  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.5 Amino acid metabolism hsa00250 Alanine, aspartate and glutamate metabolism
1. Metabolism 1.5 Amino acid metabolism hsa00280 Valine, leucine and isoleucine degradation
1. Metabolism 1.6 Metabolism of other amino acids hsa00410 beta-Alanine metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00640 Propanoate metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00650 Butanoate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
5. Organismal Systems 5.6 Nervous system hsa04727 GABAergic synapse
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0007568 aging
Biological Process GO:0048148 behavioral response to cocaine
Biological Process GO:0021549 cerebellum development
Biological Process GO:0007620 copulation
Biological Process GO:0035640 exploration behavior
Biological Process GO:0009449 gamma-aminobutyric acid biosynthetic process
Biological Process GO:0009450 gamma-aminobutyric acid catabolic process
Biological Process GO:0009448 gamma-aminobutyric acid metabolic process
Biological Process GO:0007626 locomotory behavior
Biological Process GO:0045776 negative regulation of blood pressure
Biological Process GO:0033602 negative regulation of dopamine secretion
Biological Process GO:0014053 negative regulation of gamma-aminobutyric acid secretion
Biological Process GO:0090331 negative regulation of platelet aggregation
Biological Process GO:0042135 neurotransmitter catabolic process
Biological Process GO:1904450 positive regulation of aspartate secretion
Biological Process GO:0045964 positive regulation of dopamine metabolic process
Biological Process GO:0031652 positive regulation of heat generation
Biological Process GO:0097151 positive regulation of inhibitory postsynaptic potential
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:1902722 positive regulation of prolactin secretion
Biological Process GO:0070474 positive regulation of uterine smooth muscle contraction
Biological Process GO:0042493 response to drug
Biological Process GO:0045471 response to ethanol
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0010039 response to iron ion
Biological Process GO:0035094 response to nicotine
molecular function GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity
molecular function GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity
molecular function GO:0042802 identical protein binding
molecular function GO:0051536 iron-sulfur cluster binding
molecular function GO:0046872 metal ion binding
molecular function GO:0030170 pyridoxal phosphate binding
molecular function GO:0032145 succinate-semialdehyde dehydrogenase binding
cellular component GO:0032144 4-aminobutyrate transaminase complex
cellular component GO:0005759 mitochondrial matrix
cellular component GO:0005739 mitochondrion
cellular component GO:0043005 neuron projection
Reactome
Pathway Id Pathway Name
R-HSA-112310 Neurotransmitter release cycle
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112316 Neuronal System
R-HSA-888590 GABA synthesis, release, reuptake and degradation
R-HSA-916853 Degradation of GABA
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001973 BXGD000095 Alcoholic Intoxication, Chronic Chemically-Induced Disorders; Mental Disorders
C0002622 BXGD000119 Amnesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0003123 BXGD000178 Anorexia Pathological Conditions, Signs and Symptoms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0013386 BXGD000827 Dyskinesia, Drug-Induced Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Chemically-Induced Disorders
C0014544 BXGD000926 Epilepsy Nervous System Diseases
C0017168 BXGD001101 Gastroesophageal reflux disease Digestive System Diseases
C0019337 BXGD001319 Heroin Dependence Chemically-Induced Disorders; Mental Disorders
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020429 BXGD001378 Hyperalgesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020538 BXGD001422 Hypertensive disease Cardiovascular Diseases
C0022116 BXGD001531 Ischemia Pathological Conditions, Signs and Symptoms
C0022333 BXGD001534 Jacksonian Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0023380 BXGD001640 Lethargy Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0026825 BXGD001934 Flaccid Muscle Tone Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0033922 BXGD002440 Psychomotor Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0034933 BXGD002496 Reflex, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037769 BXGD002701 West Syndrome Nervous System Diseases
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040264 BXGD002857 Tinnitus Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Otorhinolaryngologic Diseases
C0149958 BXGD003395 Complex partial seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151572 BXGD003442 Reflex, Corneal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151888 BXGD003497 Hyporeflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0153676 BXGD003679 Secondary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0234146 BXGD004626 Absent reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234533 BXGD004687 Generalized seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234535 BXGD004688 Clonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234784 BXGD004696 Reflex, Gag, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0236736 BXGD004825 Cocaine-Related Disorders Chemically-Induced Disorders; Mental Disorders
C0238111 BXGD004877 Lennox-Gastaut syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0239154 BXGD004967 High pitched cry Behavior and Behavior Mechanisms
C0241240 BXGD005089 Tall stature
C0241772 BXGD005112 Reflex, Deep Tendon, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0266470 BXGD005678 Cerebellar Hypoplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0270824 BXGD006113 Visual seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844 BXGD006115 Tonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846 BXGD006116 Epileptic drop attack Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270857 BXGD006122 Epilepsy, Reflex Nervous System Diseases
C0277839 BXGD006481 Hoffman's Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0277850 BXGD006482 Reflex, Pendular Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0278211 BXGD006507 Reflex, Corneal, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0282513 BXGD006808 Primary Progressive Aphasia (disorder) Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0342708 BXGD007532 Gamma aminobutyric acid transaminase deficiency Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0422850 BXGD008457 Seizures, Somatosensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422852 BXGD008458 Seizures, Auditory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422853 BXGD008459 Olfactory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422854 BXGD008460 Gustatory seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0422855 BXGD008461 Vertiginous seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0424230 BXGD008522 Motor retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0424295 BXGD008524 Hyperactive behavior Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0427201 BXGD008612 Floppy Muscles Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0427202 BXGD008613 Muscle Tone Atonic Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0494475 BXGD009030 Tonic - clonic seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0522345 BXGD009201 Reflex, Acoustic, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0523465 BXGD009209 Serum albumin measurement
C0525045 BXGD009255 Mood Disorders Mental Disorders
C0557874 BXGD009444 Global developmental delay
C0558845 BXGD009459 Reflex, Ankle, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558846 BXGD009460 Reflex, Triceps, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0558847 BXGD009461 Reflex, Biceps, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0576612 BXGD009529 Reflex, Anal, Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0740858 BXGD010012 Substance abuse problem Chemically-Induced Disorders; Mental Disorders
C0743002 BXGD010072 Abnormal Deep Tendon Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751056 BXGD010306 Non-epileptic convulsion Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751110 BXGD010318 Single Seizure Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751123 BXGD010326 Atonic Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751229 BXGD010359 Hypersomnolence Nervous System Diseases; Mental Disorders
C0751330 BXGD010389 Unilateral Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751456 BXGD010448 Developmental Psychomotor Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0751468 BXGD010453 Bulbocavernosus Reflex, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751469 BXGD010454 Bulbocavernousus Reflex Absent Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751470 BXGD010455 Palmo-Mental Reflex Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751471 BXGD010456 Reflex, Anal, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751472 BXGD010457 Reflex, Ankle, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751473 BXGD010458 Reflex, Ankle, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751474 BXGD010459 Reflex, Biceps, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751475 BXGD010460 Reflex, Biceps, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751476 BXGD010461 Reflex, Gag, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751477 BXGD010462 Reflex, Knee, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751478 BXGD010463 Reflex, Knee, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751479 BXGD010464 Reflex, Moro, Asymmetric Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751480 BXGD010465 Reflex, Triceps, Abnormal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751481 BXGD010466 Reflex, Triceps, Decreased Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751494 BXGD010472 Convulsive Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751496 BXGD010474 Seizures, Sensory Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1837397 BXGD014227 Severe global developmental delay
C1839630 BXGD014391 Severe muscular hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1843392 BXGD014582 Death in childhood
C1857353 BXGD015697 Posterior fossa cyst
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2347761 BXGD017049 Childhood Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C2674422 BXGD017245 Seizures, intractable
C3463824 BXGD018899 MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases
C3494422 BXGD018966 Retrognathia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C3495874 BXGD019008 Nonepileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3642347 BXGD019246 Basal-Like Breast Carcinoma
C3887506 BXGD019886 Hyperkinesia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3887898 BXGD019926 Infantile Spasm Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3900098 BXGD020106 Adult Myelodysplastic Syndrome Hemic and Lymphatic Diseases
C4048158 BXGD021890 Convulsions Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4274731 BXGD022356 Jeavons syndrome Nervous System Diseases
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317109 BXGD022725 Epileptic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4317123 BXGD022727 Myoclonic Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4505436 BXGD022962 Generalized Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000279 L-Alanine 89.09
BXGC0000497 Vanillin 152.15
BXGC0000524 4-Methoxybenzaldehyde 136.15
BXGC0000539 Anthranilic acid 137.14
BXGC0000642 4-Aminobenzoic acid 137.14
BXGC0004665 4-Aminobutyric acid 103.12
BXGC0004707 4'-Hydroxyacetophenone 136.15
BXGC0004708 4-Hydroxybenzaldehyde 122.12
BXGC0004711 4-Hydroxybenzoic acid 138.12
BXGC0004715 4-Hydroxybenzylamine 123.15
BXGC0005793 Baicalein 270.24
BXGC0006162 L-Glutamic acid 147.13
BXGC0006174 4-Hydroxybenzyl alcohol 124.14
BXGC0028048 helicide 284.09
BXGC0030094 Paroxypropione 150.07
BXGC0035923 gastrodin 286.11
BXGC0038275 Pyruvic Acid 88.02
BXGC0043088 Pyridoxal Phosphate 247.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein