Showing entry for Pyruvate kinase PKLR


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009447
Protein NamePyruvate kinase PKLR
Uniport IdP30613
GenePKLR
Gene Id5313
DomainPK; PK_C
Pfam PF00224   PF02887  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.1 Carbohydrate metabolism hsa00010 Glycolysis / Gluconeogenesis
1. Metabolism 1.4 Nucleotide metabolism hsa00230 Purine metabolism
1. Metabolism 1.1 Carbohydrate metabolism hsa00620 Pyruvate metabolism
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01200 Carbon metabolism
1. Metabolism 1.0 Global and overview maps hsa01230 Biosynthesis of amino acids
5. Organismal Systems 5.2 Endocrine system hsa04910 Insulin signaling pathway
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04930 Type II diabetes mellitus
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04932 Non-alcoholic fatty liver disease (NAFLD)
6. Human Diseases 6.7 Endocrine and metabolic diseases hsa04950 Maturity onset diabetes of the young
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0061621 canonical glycolysis
Biological Process GO:0071872 cellular response to epinephrine stimulus
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0006096 glycolytic process
Biological Process GO:0042866 pyruvate biosynthetic process
Biological Process GO:0033198 response to ATP
Biological Process GO:0051591 response to cAMP
Biological Process GO:0009749 response to glucose
Biological Process GO:0009408 response to heat
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0010226 response to lithium ion
Biological Process GO:0007584 response to nutrient
molecular function GO:0005524 ATP binding
molecular function GO:0016301 kinase activity
molecular function GO:0000287 magnesium ion binding
molecular function GO:0030955 potassium ion binding
molecular function GO:0004743 pyruvate kinase activity
cellular component GO:0005737 cytoplasm
cellular component GO:0005829 cytosol
cellular component GO:0070062 extracellular exosome
Reactome
Pathway Id Pathway Name
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002152 BXGD000104 Alloxan Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0002871 BXGD000132 Anemia Hemic and Lymphatic Diseases
C0002878 BXGD000137 Anemia, Hemolytic Hemic and Lymphatic Diseases
C0002881 BXGD000140 Anemia, Hemolytic, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0002882 BXGD000141 Anemia, Hemolytic, Congenital Nonspherocytic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0008325 BXGD000529 Cholecystitis Digestive System Diseases
C0008350 BXGD000531 Cholelithiasis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011853 BXGD000752 Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011860 BXGD000755 Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases; Endocrine System Diseases
C0017205 BXGD001105 Gaucher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0018939 BXGD001253 Hematological Disease Hemic and Lymphatic Diseases
C0020074 BXGD001358 HSAN Type IV Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020305 BXGD001374 Hydrops Fetalis Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Immune System Diseases; Hemic and Lymphatic Diseases
C0020456 BXGD001392 Hyperglycemia Nutritional and Metabolic Diseases
C0022346 BXGD001537 Icterus Pathological Conditions, Signs and Symptoms
C0023893 BXGD001716 Liver Cirrhosis, Experimental Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024530 BXGD001783 Malaria Infections
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0032461 BXGD002356 Polycythemia Hemic and Lymphatic Diseases
C0035126 BXGD002509 Reperfusion Injury Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038433 BXGD002754 Streptozotocin Diabetes Nutritional and Metabolic Diseases; Endocrine System Diseases
C0151900 BXGD003500 Serum iron raised Nutritional and Metabolic Diseases
C0153452 BXGD003647 Malignant neoplasm of gallbladder Digestive System Diseases; Neoplasms
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0206160 BXGD004166 Reticulocytosis Pathological Conditions, Signs and Symptoms
C0206161 BXGD004167 Reticulocyte count (procedure)
C0221016 BXGD004365 Red blood cell disorder Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0221278 BXGD004435 Anisocytosis
C0221281 BXGD004436 Poikilocytosis
C0235782 BXGD004769 Gallbladder Carcinoma Digestive System Diseases; Neoplasms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0241013 BXGD005075 Increased serum ferritin
C0242723 BXGD005193 Parasitemia Pathological Conditions, Signs and Symptoms; Infections
C0266781 BXGD005710 Abnormal amniotic fluid
C0268306 BXGD005891 Unconjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms
C0278678 BXGD006556 Metastatic Renal Cell Cancer
C0338508 BXGD007196 Optic Atrophy 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Eye Diseases; Nervous System Diseases
C0340968 BXGD007377 Deficiency of pyruvate kinase Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Hemic and Lymphatic Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0346993 BXGD007844 Secondary malignant neoplasm of female breast Neoplasms; Skin and Connective Tissue Diseases
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0424621 BXGD008536 Body Fat Distribution
C0494165 BXGD009022 Secondary malignant neoplasm of liver Digestive System Diseases; Neoplasms
C0520572 BXGD009093 Enzymopathy Nutritional and Metabolic Diseases
C0559506 BXGD009473 Neonatal unconjugated hyperbilirubinemia Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0686619 BXGD009835 Secondary malignant neoplasm of lymph node Pathological Conditions, Signs and Symptoms; Neoplasms
C1269683 BXGD012001 Major Depressive Disorder Mental Disorders
C1387532 BXGD012957 Chronic hemolytic anemia Hemic and Lymphatic Diseases
C1849478 BXGD015056 Increased red cell osmotic fragility
C1859236 BXGD015867 Prolonged neonatal jaundice Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1863224 BXGD016157 Adenosine Triphosphate, Elevated, Of Erythrocytes Hemic and Lymphatic Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2349595 BXGD017063 Fetal anemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Hemic and Lymphatic Diseases
C2698117 BXGD017446 Anisocyte Measurement
C3854388 BXGD019830 Hyperferritinaemia Nutritional and Metabolic Diseases
C4022546 BXGD020913 Reduced erythrocyte 2,3-diphosphoglycerate concentration
C4022892 BXGD021029 Elevated transferrin saturation
C4025735 BXGD021767 Nonspherocytic hemolytic anemia Hemic and Lymphatic Diseases
C4476595 BXGD022837 Reduced red cell pyruvate kinase activity
C4525297 BXGD023131 Stage 0 Gallbladder Cancer AJCC v8
C4525300 BXGD023132 Stage IIA Gallbladder Cancer AJCC v8
C4525301 BXGD023133 Stage IIB Gallbladder Cancer AJCC v8
C4525302 BXGD023134 Stage III Gallbladder Cancer AJCC v8
C4525305 BXGD023135 Stage IV Gallbladder Cancer AJCC v8
C4551637 BXGD023379 Erythrocytosis familial, 1 Hemic and Lymphatic Diseases
C4552000 BXGD023473 Episodic Kinesigenic Dyskinesia 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4721698 BXGD023763 Metastatic Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C4722085 BXGD023788 Malignant neoplasm of colon and/or rectum
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
BXGC0000942 Phosphoenolpyruvic acid 168.04
BXGC0002591 Potassium 39.1
BXGC0002605 Adenosine 267.24
BXGC0032798 Shikonin 288.1
BXGC0038275 Pyruvic Acid 88.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein