Showing entry for Monocarboxylate transporter 8


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT009893
Protein NameMonocarboxylate transporter 8
Uniport IdP36021
GeneSLC16A2
Gene Id6567
DomainMFS_1
Pfam PF07690  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.2 Endocrine system hsa04919 Thyroid hormone signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0089718 amino acid import across plasma membrane
Biological Process GO:0006520 cellular amino acid metabolic process
Biological Process GO:0015718 monocarboxylic acid transport
Biological Process GO:2000178 negative regulation of neural precursor cell proliferation
Biological Process GO:0043252 sodium-independent organic anion transport
Biological Process GO:0006590 thyroid hormone generation
Biological Process GO:0042403 thyroid hormone metabolic process
Biological Process GO:0070327 thyroid hormone transport
Biological Process GO:0070460 thyroid-stimulating hormone secretion
Biological Process GO:0150104 transport across blood-brain barrier
molecular function GO:0015171 amino acid transmembrane transporter activity
molecular function GO:0008028 monocarboxylic acid transmembrane transporter activity
molecular function GO:0015293 symporter activity
molecular function GO:0015349 thyroid hormone transmembrane transporter activity
molecular function GO:0005215 transporter activity
cellular component GO:0016324 apical plasma membrane
cellular component GO:0016021 integral component of membrane
cellular component GO:0005887 integral component of plasma membrane
cellular component GO:0005886 plasma membrane
Reactome
Pathway Id Pathway Name
R-HSA-382551 Transport of small molecules
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-879518 Transport of organic anions
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0000772 BXGD000009 Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0002793 BXGD000130 Anaplasia Pathological Conditions, Signs and Symptoms; Neoplasms
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004158 BXGD000261 Athetosis Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0005745 BXGD000331 Blepharoptosis Eye Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0007115 BXGD000432 Malignant neoplasm of thyroid Neoplasms; Endocrine System Diseases
C0008370 BXGD000534 Cholestasis Digestive System Diseases
C0008489 BXGD000546 Chorea Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0009024 BXGD000578 Clonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0013132 BXGD000799 Drooling Stomatognathic Diseases
C0013362 BXGD000817 Dysarthria Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0015300 BXGD000973 Exophthalmos Eye Diseases
C0015732 BXGD001018 Fecal Incontinence Digestive System Diseases
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0016202 BXGD001050 Flatfoot Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016842 BXGD001083 Congenital pectus excavatum Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0018536 BXGD001201 Hallux Valgus Musculoskeletal Diseases
C0020550 BXGD001429 Hyperthyroidism Endocrine System Diseases
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0023520 BXGD001678 Leukodystrophy Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023787 BXGD001698 Lipodystrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0024043 BXGD001728 Low T3 Syndrome Endocrine System Diseases
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026106 BXGD001889 Mild Mental Retardation Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027651 BXGD002009 Neoplasms Neoplasms
C0033377 BXGD002406 Ptosis Pathological Conditions, Signs and Symptoms
C0034935 BXGD002497 Babinski Reflex
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037772 BXGD002703 Spastic Paraplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0040128 BXGD002844 Thyroid Diseases Endocrine System Diseases
C0040136 BXGD002845 Thyroid Neoplasm Neoplasms; Endocrine System Diseases
C0040156 BXGD002849 Thyrotoxicosis Endocrine System Diseases
C0042024 BXGD002949 Urinary Incontinence Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0151889 BXGD003498 Hyperreflexia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0152421 BXGD003586 Macrotia
C0162298 BXGD003933 Joint stiffness Musculoskeletal Diseases
C0162429 BXGD003942 Malnutrition Nutritional and Metabolic Diseases
C0221163 BXGD004395 Motor Disorders Mental Disorders
C0221505 BXGD004466 Lesion of brain
C0234133 BXGD004624 Extrapyramidal sign
C0235909 BXGD004786 Impaired psychomotor development Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0238463 BXGD004938 Papillary thyroid carcinoma Neoplasms; Endocrine System Diseases
C0240379 BXGD005033 Open mouth (finding)
C0240414 BXGD005035 Hypoplasia of muscle
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0266623 BXGD005702 Congenital anomaly of neck Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0270612 BXGD006081 Leukoencephalopathy Nervous System Diseases
C0270685 BXGD006084 Cerebral calcification Nutritional and Metabolic Diseases; Nervous System Diseases
C0270971 BXGD006146 Floppy infant syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0338656 BXGD007211 Impaired cognition Mental Disorders
C0343239 BXGD007611 Benign congenital hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0409348 BXGD008384 Flexion contracture of proximal interphalangeal joint
C0423109 BXGD008470 Upward slant of palpebral fissure
C0424605 BXGD008535 Developmental delay (disorder) Mental Disorders
C0426970 BXGD008598 Spastic Quadriplegia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0432072 BXGD008718 Dysmorphic features
C0497552 BXGD009067 Congenital neurologic anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0541794 BXGD009262 Skeletal muscle atrophy
C0549473 BXGD009384 Thyroid carcinoma Neoplasms; Endocrine System Diseases
C0557874 BXGD009444 Global developmental delay
C0586553 BXGD009609 Raised TSH level Endocrine System Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0751265 BXGD010370 Learning Disabilities Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0752210 BXGD010697 Dyskinesias, Paroxysmal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0795889 BXGD010759 Allan-Herndon-Dudley syndrome (AHDS) Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0857516 BXGD011153 Floppy
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1280433 BXGD012125 Lipoatrophy Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C1389113 BXGD012965 Generalized amyotrophy
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1837397 BXGD014227 Severe global developmental delay
C1837463 BXGD014235 Narrow face
C1839758 BXGD014402 Narrow forehead
C1839888 BXGD014424 Decreased activity of the pyruvate dehydrogenase complex
C1845272 BXGD014735 Prominent antihelix
C1845274 BXGD014736 Abnormal conjugate eye movement
C1846149 BXGD014786 Intellectual disability, progressive Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1847879 BXGD014895 X-linked dominant inheritance
C1854418 BXGD015402 Biparietal narrowing
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1854919 BXGD015442 Severe psychomotor retardation
C1855285 BXGD015483 Protruding ear
C1857276 BXGD015688 Trichohepatoenteric Syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases
C1862095 BXGD016100 Bilateral single transverse palmar creases
C1862689 BXGD016136 Stahl ear
C2267233 BXGD017017 Neonatal Hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2674608 BXGD017250 Feeding difficulties in infancy
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2940786 BXGD018184 Thyroid Hormone Resistance Syndrome Endocrine System Diseases
C3649644 BXGD019251 Congenital condition
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4021242 BXGD020592 Hypoplasia of the zygomatic bone
C4021758 BXGD020761 Delayed CNS myelination
C4024655 BXGD021359 Underfolded superior helices
C4274084 BXGD022344 Pelizaeus Merzbacher like disease
C4552810 BXGD023525 Irritability, CTCAE
C4722330 BXGD023801 Generalized Thyroid Hormone Resistance Endocrine System Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0038275 Pyruvic Acid 88.02
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein