protein

Showing entry for Integrin alpha-X

General Target Information
BXGT Id	BXGT008592
Protein Name	Integrin alpha-X
Uniport Id	P20702
Gene	ITGAX
Gene Id	3687
Domain	FG-GAP; Integrin_alpha; Integrin_alpha2; VWA
Pfam	PF01839 PF00357 PF08441 PF00092
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.1 Immune system	hsa04610	Complement and coagulation cascades
4. Cellular Processes	4.5 Cell motility	hsa04810	Regulation of actin cytoskeleton
6. Human Diseases	6.8 Infectious diseases: Bacterial	hsa05152	Tuberculosis

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0009887	animal organ morphogenesis
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0019221	cytokine-mediated signaling pathway
Biological Process	GO:0030198	extracellular matrix organization
Biological Process	GO:0034113	heterotypic cell-cell adhesion
Biological Process	GO:0007229	integrin-mediated signaling pathway
Biological Process	GO:0050900	leukocyte migration
Biological Process	GO:0043312	neutrophil degranulation
Biological Process	GO:0045766	positive regulation of angiogenesis
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:1905956	positive regulation of endothelial tube morphogenesis
Biological Process	GO:0010628	positive regulation of gene expression
Biological Process	GO:0031643	positive regulation of myelination
molecular function	GO:0005178	integrin binding
molecular function	GO:0046872	metal ion binding
molecular function	GO:0030971	receptor tyrosine kinase binding
molecular function	GO:0038023	signaling receptor activity
cellular component	GO:0009986	cell surface
cellular component	GO:0101003	ficolin-1-rich granule membrane
cellular component	GO:0034689	integrin alphaX-beta2 complex
cellular component	GO:0008305	integrin complex
cellular component	GO:0016020	membrane
cellular component	GO:0005886	plasma membrane
cellular component	GO:0030667	secretory granule membrane
cellular component	GO:0070821	tertiary granule membrane

Reactome

Pathway Id	Pathway Name
R-HSA-109582	Hemostasis
R-HSA-1280215	Cytokine Signaling in Immune system
R-HSA-1474244	Extracellular matrix organization
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-202733	Cell surface interactions at the vascular wall
R-HSA-216083	Integrin cell surface interactions
R-HSA-3000178	ECM proteoglycans
R-HSA-449147	Signaling by Interleukins
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695	Neutrophil degranulation

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002395	BXGD000111	Alzheimer's Disease	Nervous System Diseases; Mental Disorders
C0003850	BXGD000225	Arteriosclerosis	Cardiovascular Diseases
C0003864	BXGD000231	Arthritis	Musculoskeletal Diseases
C0003873	BXGD000236	Rheumatoid Arthritis	Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096	BXGD000252	Asthma	Respiratory Tract Diseases; Immune System Diseases
C0004153	BXGD000260	Atherosclerosis	Cardiovascular Diseases
C0004364	BXGD000270	Autoimmune Diseases	Immune System Diseases
C0004943	BXGD000297	Behcet Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142	BXGD000374	Malignant neoplasm of breast	Neoplasms; Skin and Connective Tissue Diseases
C0007097	BXGD000424	Carcinoma	Neoplasms
C0007102	BXGD000425	Malignant tumor of colon	Digestive System Diseases; Neoplasms
C0007103	BXGD000426	Malignant neoplasm of endometrium	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0007137	BXGD000445	Squamous cell carcinoma	Neoplasms
C0007684	BXGD000472	Central Nervous System Infection	Infections; Nervous System Diseases
C0007789	BXGD000488	Cerebral Palsy	Nervous System Diseases
C0009319	BXGD000596	Colitis	Digestive System Diseases
C0009324	BXGD000597	Ulcerative Colitis	Digestive System Diseases
C0009402	BXGD000605	Colorectal Carcinoma	Digestive System Diseases; Neoplasms
C0009447	BXGD000613	Common Variable Immunodeficiency	Immune System Diseases
C0010346	BXGD000664	Crohn Disease	Digestive System Diseases
C0010823	BXGD000690	Cytomegalovirus Infections	Infections
C0011311	BXGD000714	Dengue Fever	Infections
C0011603	BXGD000734	Dermatitis	Skin and Connective Tissue Diseases
C0011847	BXGD000749	Diabetes	Endocrine System Diseases
C0011849	BXGD000751	Diabetes Mellitus	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854	BXGD000753	Diabetes Mellitus, Insulin-Dependent	Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011860	BXGD000755	Diabetes Mellitus, Non-Insulin-Dependent	Nutritional and Metabolic Diseases; Endocrine System Diseases
C0012546	BXGD000776	Diphtheria	Infections
C0014057	BXGD000880	Japanese Encephalitis	Infections; Nervous System Diseases
C0014070	BXGD000887	Encephalomyelitis	Infections; Nervous System Diseases
C0016529	BXGD001068	Forced expiratory volume function
C0017152	BXGD001096	Gastritis	Digestive System Diseases
C0017638	BXGD001132	Glioma	Neoplasms
C0017661	BXGD001139	IGA Glomerulonephritis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Immune System Diseases
C0018133	BXGD001176	Graft-vs-Host Disease	Immune System Diseases
C0018889	BXGD001243	Helminthiasis	Infections
C0019163	BXGD001295	Hepatitis B	Digestive System Diseases; Infections
C0019196	BXGD001301	Hepatitis C	Digestive System Diseases; Infections
C0019693	BXGD001346	HIV Infections	Infections; Immune System Diseases
C0020429	BXGD001378	Hyperalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020443	BXGD001385	Hypercholesterolemia	Nutritional and Metabolic Diseases
C0020538	BXGD001422	Hypertensive disease	Cardiovascular Diseases
C0021390	BXGD001503	Inflammatory Bowel Diseases	Digestive System Diseases
C0022104	BXGD001529	Irritable Bowel Syndrome	Digestive System Diseases
C0022575	BXGD001555	Keratoconjunctivitis Sicca	Eye Diseases
C0023434	BXGD001643	Chronic Lymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023443	BXGD001648	Hairy Cell Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023452	BXGD001651	Childhood Acute Lymphoblastic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023467	BXGD001658	Leukemia, Myelocytic, Acute	Neoplasms
C0023486	BXGD001668	Prolymphocytic Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023487	BXGD001669	Acute Promyelocytic Leukemia	Neoplasms
C0023493	BXGD001672	Adult T-Cell Lymphoma/Leukemia	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0023530	BXGD001683	Leukopenia	Hemic and Lymphatic Diseases
C0024131	BXGD001736	Lupus Vulgaris	Infections; Skin and Connective Tissue Diseases
C0024138	BXGD001738	Lupus Erythematosus, Discoid	Skin and Connective Tissue Diseases
C0024141	BXGD001740	Lupus Erythematosus, Systemic	Skin and Connective Tissue Diseases; Immune System Diseases
C0024282	BXGD001755	Lymphocytosis	Hemic and Lymphatic Diseases
C0024299	BXGD001758	Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024301	BXGD001759	Lymphoma, Follicular	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0024530	BXGD001783	Malaria	Infections
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0025202	BXGD001832	melanoma	Neoplasms
C0026470	BXGD001903	Monoclonal Gammopathy of Undetermined Significance	Immune System Diseases; Hemic and Lymphatic Diseases
C0026764	BXGD001928	Multiple Myeloma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769	BXGD001930	Multiple Sclerosis	Immune System Diseases; Nervous System Diseases
C0026896	BXGD001946	Myasthenia Gravis	Neoplasms; Immune System Diseases; Nervous System Diseases
C0026936	BXGD001950	Mycoplasma Infections	Infections
C0027059	BXGD001965	Myocarditis	Cardiovascular Diseases
C0027430	BXGD001988	Nasal Polyps	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C0027583	BXGD002001	Nematode infections	Infections
C0027627	BXGD002006	Neoplasm Metastasis	Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651	BXGD002009	Neoplasms	Neoplasms
C0027708	BXGD002025	Nephroblastoma	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027962	BXGD002064	Melanocytic nevus	Neoplasms
C0028754	BXGD002082	Obesity	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028756	BXGD002083	Obesity, Morbid	Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0032285	BXGD002344	Pneumonia	Infections; Respiratory Tract Diseases
C0032460	BXGD002355	Polycystic Ovary Syndrome	Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033770	BXGD002417	Prune Belly Syndrome	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0033860	BXGD002438	Psoriasis	Skin and Connective Tissue Diseases
C0034050	BXGD002452	Pulmonary Alveolar Proteinosis	Respiratory Tract Diseases
C0034067	BXGD002456	Pulmonary Emphysema	Respiratory Tract Diseases
C0034069	BXGD002458	Pulmonary Fibrosis	Respiratory Tract Diseases
C0035235	BXGD002519	Respiratory Syncytial Virus Infections	Infections
C0036202	BXGD002581	Sarcoidosis	Hemic and Lymphatic Diseases
C0036690	BXGD002632	Septicemia	Pathological Conditions, Signs and Symptoms; Infections
C0037284	BXGD002679	Skin lesion	Skin and Connective Tissue Diseases
C0038358	BXGD002748	Gastric ulcer	Digestive System Diseases
C0041296	BXGD002903	Tuberculosis	Infections
C0041327	BXGD002916	Tuberculosis, Pulmonary	Infections; Respiratory Tract Diseases
C0042769	BXGD002999	Virus Diseases	Infections
C0079744	BXGD003090	Diffuse Large B-Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0085166	BXGD003136	Bacterial Vaginosis	Female Urogenital Diseases and Pregnancy Complications; Infections
C0085207	BXGD003140	Gestational Diabetes	Nutritional and Metabolic Diseases; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0085220	BXGD003142	Cerebral Amyloid Angiopathy	Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0085702	BXGD003247	Monocytosis	Pathological Conditions, Signs and Symptoms; Hemic and Lymphatic Diseases
C0151332	BXGD003415	Active tuberculosis	Infections
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0155626	BXGD003806	Acute myocardial infarction	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0162871	BXGD003996	Aortic Aneurysm, Abdominal	Cardiovascular Diseases
C0178874	BXGD004037	Tumor Progression	Pathological Conditions, Signs and Symptoms
C0206139	BXGD004159	Lichen Planus, Oral	Skin and Connective Tissue Diseases; Stomatognathic Diseases
C0239946	BXGD005010	Fibrosis, Liver	Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0242379	BXGD005157	Malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C0242596	BXGD005181	Neoplasm, Residual	Pathological Conditions, Signs and Symptoms; Neoplasms
C0242647	BXGD005184	Mucosa-Associated Lymphoid Tissue Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0243026	BXGD005210	Sepsis	Pathological Conditions, Signs and Symptoms; Infections
C0263361	BXGD005292	Psoriasis vulgaris	Skin and Connective Tissue Diseases
C0268393	BXGD005931	Familial Cerebral Amyloid Angiopathy	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C0269102	BXGD006053	Endometrioma	Female Urogenital Diseases and Pregnancy Complications
C0271650	BXGD006227	Impaired glucose tolerance	Nutritional and Metabolic Diseases
C0275518	BXGD006375	Acute infectious disease	Pathological Conditions, Signs and Symptoms; Infections
C0276447	BXGD006425	Rhinovirus infection	Infections
C0278762	BXGD006579	Adult Diffuse Large Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0278840	BXGD006600	Childhood Diffuse Large Cell Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0279565	BXGD006638	Invasive Lobular Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0375023	BXGD007970	Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0409974	BXGD008401	Lupus Erythematosus	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Immune System Diseases
C0476089	BXGD008977	Endometrial Carcinoma	Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0520678	BXGD009100	Postpartum psychosis	Mental Disorders
C0524620	BXGD009236	Metabolic Syndrome X	Nutritional and Metabolic Diseases
C0543697	BXGD009291	Mixed cryoglobulinemia	Immune System Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0678222	BXGD009749	Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases
C0684249	BXGD009790	Carcinoma of lung	Neoplasms; Respiratory Tract Diseases
C0686619	BXGD009835	Secondary malignant neoplasm of lymph node	Pathological Conditions, Signs and Symptoms; Neoplasms
C0699790	BXGD009866	Colon Carcinoma	Digestive System Diseases; Neoplasms
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0699949	BXGD009872	airway disease	Pathological Conditions, Signs and Symptoms; Respiratory Tract Diseases
C0702166	BXGD009912	Acne	Skin and Connective Tissue Diseases
C0740391	BXGD009987	Middle Cerebral Artery Occlusion	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0855095	BXGD011071	Small Lymphocytic Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C0856169	BXGD011096	Endothelial dysfunction
C0867389	BXGD011300	Chronic graft-versus-host disease	Immune System Diseases
C0878544	BXGD011368	Cardiomyopathies	Cardiovascular Diseases
C1096184	BXGD011607	West Nile viral infection	Infections; Nervous System Diseases
C1136085	BXGD011709	Monoclonal Gammapathies	Immune System Diseases; Hemic and Lymphatic Diseases
C1305855	BXGD012348	Body mass index
C1306460	BXGD012362	Primary malignant neoplasm of lung	Neoplasms; Respiratory Tract Diseases
C1332206	BXGD012504	Adult Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1332979	BXGD012571	Childhood Lymphoma	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1334011	BXGD012676	High Grade Cervical Intraepithelial Neoplasia	Neoplasms
C1368771	BXGD012901	Burkitt-like lymphoma	Neoplasms; Infections; Immune System Diseases; Hemic and Lymphatic Diseases
C1456781	BXGD013123	Benign melanocytic nevus	Neoplasms
C1510489	BXGD013173	Cerebral Amyloid Angiopathy, Hereditary	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases; Cardiovascular Diseases
C1536999	BXGD013348	cancer angiogenesis
C1609538	BXGD013444	Latent Tuberculosis	Infections
C1720830	BXGD013687	Painful Bladder Syndrome	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1832661	BXGD013866	ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Respiratory Tract Diseases
C1837218	BXGD014207	Cleft palate, isolated	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Stomatognathic Diseases
C1842937	BXGD014546	AURAL ATRESIA, CONGENITAL	Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C1868683	BXGD016526	B-CELL MALIGNANCY, LOW-GRADE
C2004493	BXGD016875	Leukemia, B-Cell	Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C2062441	BXGD016897	Influenza A
C2314882	BXGD017018	Reproductive tract infection	Female Urogenital Diseases and Pregnancy Complications; Infections; Male Urogenital Diseases
C2675014	BXGD017263	Mullerian Aplasia and Hyperandrogenism	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C2711227	BXGD017478	Steatohepatitis	Digestive System Diseases
C2936349	BXGD018109	Plaque, Amyloid	Pathological Conditions, Signs and Symptoms
C2936664	BXGD018125	Acquired Hypogammaglobulinemia	Immune System Diseases
C3241937	BXGD018578	Nonalcoholic Steatohepatitis	Digestive System Diseases
C3267073	BXGD018613	Autoinflammatory disease
C3495814	BXGD019005	Fulminant type 1 diabetes mellitus
C3536663	BXGD019068	Acute deep venous thrombosis	Cardiovascular Diseases
C3539878	BXGD019087	Triple Negative Breast Neoplasms	Neoplasms; Skin and Connective Tissue Diseases
C3714636	BXGD019421	Pneumonitis	Infections; Respiratory Tract Diseases
C3875321	BXGD019874	Inflammatory dermatosis	Skin and Connective Tissue Diseases
C4048329	BXGD021904	Immunosuppression
C4082764	BXGD022093	Gastrointestinal infection	Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Infections
C4331921	BXGD022817	Obesity-Associated Insulin Resistance
C4529962	BXGD023178	Fatty Liver Disease
C4722518	BXGD023806	Triple-Negative Breast Carcinoma	Neoplasms; Skin and Connective Tissue Diseases

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0002586	Calcium		40.08
BXGC0002588	Magnesium		24.31
BXGC0003705	Chloride		35.45
BXGC0018397	beta-1,4-mannan		180.06
BXGC0050194	alpha-D-Mannose		180.06

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}