protein

Showing entry for Sodium channel protein type 9 subunit alpha

General Target Information
BXGT Id	BXGT013610
Protein Name	Sodium channel protein type 9 subunit alpha
Uniport Id	Q15858
Gene	SCN9A
Gene Id	6335
Domain	Ion_trans; Na_trans_assoc; Na_trans_cytopl
Pfam	PF00520 PF06512 PF11933
Organism	Homo sapiens (Human)

Target protein affiliated biological pathways

KEGG

Class	Subclass	KEGG Id	Pathway Name
5. Organismal Systems	5.7 Sensory system	hsa04742	Taste transduction

Gene Ontology

GO Type	GO Id	Gene Ontology
Biological Process	GO:0048266	behavioral response to pain
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0086010	membrane depolarization during action potential
Biological Process	GO:0019228	neuronal action potential
Biological Process	GO:0009791	post-embryonic development
Biological Process	GO:0034765	regulation of ion transmembrane transport
Biological Process	GO:0009636	response to toxic substance
Biological Process	GO:0019233	sensory perception of pain
Biological Process	GO:0035725	sodium ion transmembrane transport
Biological Process	GO:0006814	sodium ion transport
molecular function	GO:0005261	cation channel activity
molecular function	GO:0031402	sodium ion binding
molecular function	GO:0005244	voltage-gated ion channel activity
molecular function	GO:0005248	voltage-gated sodium channel activity
cellular component	GO:0030424	axon
cellular component	GO:0005887	integral component of plasma membrane
cellular component	GO:0005886	plasma membrane
cellular component	GO:0001518	voltage-gated sodium channel complex

Reactome

Pathway Id	Pathway Name
R-HSA-1266738	Developmental Biology
R-HSA-373760	L1CAM interactions
R-HSA-397014	Muscle contraction
R-HSA-422475	Axon guidance
R-HSA-445095	Interaction between L1 and Ankyrins
R-HSA-5576891	Cardiac conduction
R-HSA-5576892	Phase 0 - rapid depolarisation
R-HSA-9675108	Nervous system development

Target protein-related diseases

Disease

CUI Id	BXGD Id	Disease Name	Disease Class
C0002768	BXGD000128	Congenital Pain Insensitivity	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0003028	BXGD000170	Anhidrosis	Skin and Connective Tissue Diseases
C0003126	BXGD000180	Anosmia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0003467	BXGD000194	Anxiety	Behavior and Behavior Mechanisms
C0004134	BXGD000256	Ataxia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006012	BXGD000360	Borderline Personality Disorder	Mental Disorders
C0006826	BXGD000408	Malignant Neoplasms	Neoplasms
C0009806	BXGD000633	Constipation	Pathological Conditions, Signs and Symptoms
C0009952	BXGD000639	Febrile Convulsions	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0010054	BXGD000647	Coronary Arteriosclerosis	Cardiovascular Diseases
C0011991	BXGD000766	Diarrhea	Pathological Conditions, Signs and Symptoms
C0013363	BXGD000818	Dysautonomia	Nervous System Diseases
C0014544	BXGD000926	Epilepsy	Nervous System Diseases
C0014550	BXGD000930	Myoclonic Epilepsy	Nervous System Diseases
C0014804	BXGD000951	Erythromelalgia	Cardiovascular Diseases
C0014805	BXGD000952	Primary Erythermalgia	Cardiovascular Diseases
C0016053	BXGD001041	Fibromyalgia	Musculoskeletal Diseases; Nervous System Diseases
C0016202	BXGD001050	Flatfoot	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0016382	BXGD001054	Flushing	Pathological Conditions, Signs and Symptoms
C0017168	BXGD001101	Gastroesophageal reflux disease	Digestive System Diseases
C0019270	BXGD001311	Hernia	Pathological Conditions, Signs and Symptoms
C0019372	BXGD001329	Herpesviridae Infections	Infections
C0020072	BXGD001357	Hereditary Sensory Autonomic Neuropathy, Type 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020075	BXGD001359	Hereditary Sensory Autonomic Neuropathy, Type 5	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0020429	BXGD001378	Hyperalgesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0020458	BXGD001393	Hyperhidrosis disorder	Skin and Connective Tissue Diseases
C0020507	BXGD001413	Hyperplasia	Pathological Conditions, Signs and Symptoms
C0020620	BXGD001448	Hypohidrosis	Skin and Connective Tissue Diseases
C0020672	BXGD001461	Hypothermia, natural	Pathological Conditions, Signs and Symptoms
C0022575	BXGD001555	Keratoconjunctivitis Sicca	Eye Diseases
C0023418	BXGD001642	leukemia	Neoplasms
C0024003	BXGD001726	Lordosis	Musculoskeletal Diseases
C0024623	BXGD001791	Malignant neoplasm of stomach	Digestive System Diseases; Neoplasms
C0026827	BXGD001936	Muscle hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027796	BXGD002037	Neuralgia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027889	BXGD002057	Hereditary Sensory and Autonomic Neuropathies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0029408	BXGD002137	Degenerative polyarthritis	Musculoskeletal Diseases
C0030193	BXGD002191	Pain	Pathological Conditions, Signs and Symptoms
C0030201	BXGD002194	Pain, Postoperative	Pathological Conditions, Signs and Symptoms
C0030252	BXGD002199	Palpitations	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Cardiovascular Diseases
C0030567	BXGD002240	Parkinson Disease	Nervous System Diseases
C0030578	BXGD002243	Paronychia Inflammation	Infections; Skin and Connective Tissue Diseases
C0031117	BXGD002285	Peripheral Neuropathy	Nervous System Diseases
C0032768	BXGD002370	Postherpetic neuralgia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0033578	BXGD002408	Prostatic Neoplasms	Neoplasms; Male Urogenital Diseases
C0033774	BXGD002419	Pruritus	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0036421	BXGD002613	Systemic Scleroderma	Skin and Connective Tissue Diseases
C0036572	BXGD002625	Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0037140	BXGD002667	B Virus Infection	Infections
C0037650	BXGD002695	Somatoform Disorder	Mental Disorders
C0038220	BXGD002740	Status Epilepticus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0038870	BXGD002782	Neuralgia, Supraorbital	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039231	BXGD002799	Tachycardia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0040822	BXGD002885	Tremor	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0041834	BXGD002935	Erythema	Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0042024	BXGD002949	Urinary Incontinence	Pathological Conditions, Signs and Symptoms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0042384	BXGD002979	Vasculitis	Cardiovascular Diseases
C0042656	BXGD002995	Neuralgia, Vidian	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0043352	BXGD003045	Xerostomia	Stomatognathic Diseases
C0149886	BXGD003379	Seizure, Febrile, Simple	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0149958	BXGD003395	Complex partial seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0150055	BXGD003401	Chronic pain	Pathological Conditions, Signs and Symptoms
C0151572	BXGD003442	Reflex, Corneal, Decreased	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151611	BXGD003447	Electroencephalogram abnormal	Nervous System Diseases
C0151744	BXGD003469	Myocardial Ischemia	Cardiovascular Diseases
C0151827	BXGD003483	Eye pain	Pathological Conditions, Signs and Symptoms; Eye Diseases
C0151854	BXGD003487	Abnormal platelets	Hemic and Lymphatic Diseases
C0151888	BXGD003497	Hyporeflexia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0151934	BXGD003504	Hypogeusia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0231528	BXGD004496	Myalgia	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0233565	BXGD004590	Bradykinesia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234146	BXGD004626	Absent reflex	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234230	BXGD004635	Pain, Burning	Pathological Conditions, Signs and Symptoms
C0234241	BXGD004638	Indifference to pain	Pathological Conditions, Signs and Symptoms; Mental Disorders
C0234247	BXGD004642	Neuralgia, Atypical	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234249	BXGD004643	Neuralgia, Stump	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234252	BXGD004646	Mechanical pain	Pathological Conditions, Signs and Symptoms
C0234259	BXGD004649	Sensitive to smells	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0234985	BXGD004708	Mental deterioration	Mental Disorders
C0235946	BXGD004789	Cerebral atrophy	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0235974	BXGD004796	Pancreatic carcinoma	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0236000	BXGD004803	Jaw pain	Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Stomatognathic Diseases
C0238637	BXGD004948	Anal pain	Pathological Conditions, Signs and Symptoms; Digestive System Diseases; Nervous System Diseases
C0240940	BXGD005065	Scalp pain	Pathological Conditions, Signs and Symptoms
C0270834	BXGD006114	Complex partial seizure with impairment of consciousness	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270844	BXGD006115	Tonic Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270846	BXGD006116	Epileptic drop attack	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0270914	BXGD006131	Hereditary Motor and Sensory-Neuropathy Type II	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0271291	BXGD006183	Corneal anesthesia	Eye Diseases
C0282488	BXGD006804	Interstitial Cystitis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0338478	BXGD007184	Idiopathic Myoclonic Epilepsy	Nervous System Diseases
C0338479	BXGD007185	Symptomatic Myoclonic Epilepsy	Nervous System Diseases
C0338656	BXGD007211	Impaired cognition	Mental Disorders
C0344232	BXGD007659	Blurred vision	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0344307	BXGD007664	Absence of pain sensation	Pathological Conditions, Signs and Symptoms; Mental Disorders
C0346647	BXGD007832	Malignant neoplasm of pancreas	Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349506	BXGD007912	Photosensitivity of skin	Skin and Connective Tissue Diseases
C0376358	BXGD007992	Malignant neoplasm of prostate	Neoplasms; Male Urogenital Diseases
C0376532	BXGD008000	Epilepsy, Rolandic	Nervous System Diseases
C0391976	BXGD008022	Pain Disorder	Mental Disorders
C0393695	BXGD008121	Early Childhood Epilepsy, Myoclonic	Nervous System Diseases
C0393702	BXGD008124	Myoclonic Astatic Epilepsy	Nervous System Diseases
C0393703	BXGD008125	Myoclonic Absence Epilepsy	Nervous System Diseases
C0423711	BXGD008498	Neuralgia, Perineal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0423712	BXGD008499	Neuralgia, Iliohypogastric Nerve	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0424230	BXGD008522	Motor retardation	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0426886	BXGD008594	Tapering fingers (finding)
C0426900	BXGD008596	Tibial torsion
C0428977	BXGD008644	Bradycardia	Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0431380	BXGD008680	Cortical Dysplasia	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0432262	BXGD008760	Dysosteosclerosis	Musculoskeletal Diseases
C0438414	BXGD008802	Myoclonic Encephalopathy	Nervous System Diseases
C0442874	BXGD008814	Neuropathy	Nervous System Diseases
C0458219	BXGD008903	Complex Regional Pain Syndromes	Nervous System Diseases
C0494475	BXGD009030	Tonic - clonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0497552	BXGD009067	Congenital neurologic anomalies	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0520947	BXGD009126	Clumsiness - motor delay	Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0520966	BXGD009128	Abnormal coordination	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0541794	BXGD009262	Skeletal muscle atrophy
C0543888	BXGD009300	Epileptic encephalopathy	Nervous System Diseases
C0557874	BXGD009444	Global developmental delay
C0598589	BXGD009667	Inherited neuropathies	Nervous System Diseases
C0600040	BXGD009684	Chronic interstitial cystitis	Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0600139	BXGD009695	Prostate carcinoma	Neoplasms; Male Urogenital Diseases
C0699739	BXGD009861	Sensory Neuropathy, Hereditary	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0699791	BXGD009867	Stomach Carcinoma	Digestive System Diseases; Neoplasms
C0740447	BXGD009998	Diabetic peripheral neuropathy	Nervous System Diseases; Endocrine System Diseases
C0751120	BXGD010324	Benign Infantile Myoclonic Epilepsy	Nervous System Diseases
C0751122	BXGD010325	Infantile Severe Myoclonic Epilepsy	Nervous System Diseases
C0751371	BXGD010415	Neuralgia, Ilioinguinal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751372	BXGD010416	Nerve Pain	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751373	BXGD010417	Paroxysmal Nerve Pain	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751495	BXGD010473	Seizures, Focal	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0752323	BXGD010716	Focal Clonic Seizures	Nervous System Diseases
C0853946	BXGD010987	Pain worsened
C0856975	BXGD011127	Autistic behavior	Behavior and Behavior Mechanisms
C0877017	BXGD011329	Generalized tonic-clonic seizures with focal onset	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0917800	BXGD011411	Epilepsy, Myoclonic, Infantile	Nervous System Diseases
C0917990	BXGD011424	Acro-Osteolysis	Musculoskeletal Diseases
C1145628	BXGD011763	Autonomic nervous system disorders	Nervous System Diseases
C1260880	BXGD011837	Rhinorrhea	Infections; Respiratory Tract Diseases; Otorhinolaryngologic Diseases
C1262211	BXGD011876	Diarrhoea predominant irritable bowel syndrome
C1269955	BXGD012005	Tumor Cell Invasion
C1298685	BXGD012249	Chronic pain syndrome	Pathological Conditions, Signs and Symptoms
C1306459	BXGD012361	Primary malignant neoplasm	Neoplasms
C1510586	BXGD013176	Autism Spectrum Disorders	Mental Disorders
C1557375	BXGD013360	Blurred Vision, CTCAE
C1611743	BXGD013456	Familial (FPAH)
C1720983	BXGD013698	Channelopathies	Pathological Conditions, Signs and Symptoms
C1833225	BXGD013904	Dystrophic toenail
C1833661	BXGD013935	PAROXYSMAL EXTREME PAIN DISORDER	Pathological Conditions, Signs and Symptoms
C1834433	BXGD013973	Obsessive-compulsive trait	Behavior and Behavior Mechanisms
C1836830	BXGD014165	Developmental regression	Mental Disorders
C1837522	BXGD014244	Impaired pain sensation
C1837602	BXGD014250	Painless fractures due to injury
C1839333	BXGD014369	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2	Nervous System Diseases
C1844690	BXGD014662	Limited knee extension
C1846620	BXGD014832	Hemiclonic seizures	Nervous System Diseases
C1847514	BXGD014868	Postnatal microcephaly
C1849148	BXGD015014	Decreased sensory nerve conduction velocity
C1849265	BXGD015028	Overgrowth
C1852289	BXGD015270	Autoamputation of digits	Musculoskeletal Diseases
C1852581	BXGD015294	EPILEPSY, BENIGN NEONATAL, 2	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1854301	BXGD015391	Motor delay	Mental Disorders
C1854494	BXGD015409	Slow progression
C1855106	BXGD015459	Neonatal onset
C1855739	BXGD015538	Indifference to Pain, Congenital, Autosomal Recessive	Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1857171	BXGD015680	Episodic hyperhidrosis	Skin and Connective Tissue Diseases
C1857640	BXGD015726	Decreased nerve conduction velocity
C1858120	BXGD015774	Generalized hypotonia	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1858285	BXGD015781	Decreased number of peripheral myelinated nerve fibers
C1861403	BXGD016045	Variable expressivity
C1867864	BXGD016472	Poor fine motor coordination
C1867971	BXGD016477	Acute episodes of neuropathic symptoms
C2364082	BXGD017123	Sense of smell impaired	Nervous System Diseases
C2674432	BXGD017246	Reduced bone mineral density
C2674608	BXGD017250	Feeding difficulties in infancy
C2751778	BXGD017739	Generalized Epilepsy With Febrile Seizures Plus, 7	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2752089	BXGD017768	Neuropathy, Hereditary Sensory And Autonomic, Type IIA	Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C3151229	BXGD018411	FEBRILE SEIZURES, FAMILIAL, 3B
C3160712	BXGD018467	Palpitations, CTCAE
C3160917	BXGD018499	Bladder pain syndrome
C3178789	BXGD018537	Widespread Chronic Pain	Pathological Conditions, Signs and Symptoms
C3276706	BXGD018694	Small Fiber Neuropathy	Nervous System Diseases
C3502809	BXGD019049	Generalized Epilepsy with Febrile Seizures Plus	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3551426	BXGD019146	Dystrophic fingernails
C3806482	BXGD019514	Recurrent respiratory infections	Infections; Respiratory Tract Diseases
C3810365	BXGD019652	Central visual impairment	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C3889476	BXGD020004	Benign Familial Convulsion	Nervous System Diseases
C4012054	BXGD020118	NEUROPATHY, HEREDITARY SENSORY AND AUTONOMIC, TYPE IID
C4021611	BXGD020697	Abnormality of epiphysis morphology
C4021735	BXGD020743	Abnormality of the hip bone
C4021741	BXGD020749	Abnormal cortical bone morphology
C4021745	BXGD020752	Abnormality of the musculature
C4021759	BXGD020762	Generalized myoclonic seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4021768	BXGD020766	Abnormality of metabolism/homeostasis
C4021801	BXGD020791	Lacrimation abnormality
C4022738	BXGD020974	Neurodevelopmental delay
C4023511	BXGD021206	Obtundation status	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4023683	BXGD021240	EEG with spike-wave complexes
C4023691	BXGD021245	Abnormality of pain sensation	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4024945	BXGD021492	Generalized cerebral atrophy/hypoplasia
C4025660	BXGD021715	Abnormality of the ankles
C4025676	BXGD021727	Abnormality of the knee
C4025744	BXGD021771	Foot acroosteolysis
C4048268	BXGD021896	Cortical visual impairment	Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C4316903	BXGD022711	Absence Seizures	Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4551549	BXGD023343	Early Infantile Epileptic Encephalopathy 6	Nervous System Diseases
C4552061	BXGD023480	Mandibular pain	Pathological Conditions, Signs and Symptoms
C4552662	BXGD023518	Rhinorrhea, CTCAE
C4553071	BXGD023533	Anal Pain, CTCAE 5
C4721453	BXGD023744	Peripheral Nervous System Diseases	Nervous System Diseases
C4732740	BXGD023896	Acral ulceration

Target protein-related compounds

Compounds

BXGC Id	Compound Name	Strcuture	Molecular Weight
BXGC0024988	Nifedipine		346.12
BXGC0041018	Saxitoxin		299.13
BXGC0049369	Tetrodotoxin		319.1

The target protein-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compound^{? Number of compound in food, higher numbers indicate the food are more associated with the protein}