Showing entry for NACHT, LRR and PYD domains-containing protein 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT020206
Protein NameNACHT, LRR and PYD domains-containing protein 1
Uniport IdQ9C000
GeneNLRP1
Gene Id22861
DomainCARD; FIIND; LRR_6; NACHT; NLRC4_HD2; NOD2_WH; PYRIN
Pfam PF00619   PF13553   PF13516   PF05729   PF17776   PF17779   PF02758  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.1 Immune system hsa04621 NOD-like receptor signaling pathway
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0006915 apoptotic process
Biological Process GO:0042742 defense response to bacterium
Biological Process GO:0006954 inflammatory response
Biological Process GO:0045087 innate immune response
Biological Process GO:0051402 neuron apoptotic process
Biological Process GO:1904784 NLRP1 inflammasome complex assembly
Biological Process GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Process GO:0032731 positive regulation of interleukin-1 beta production
Biological Process GO:0050727 regulation of inflammatory response
Biological Process GO:0032495 response to muramyl dipeptide
Biological Process GO:0016032 viral process
molecular function GO:0005524 ATP binding
molecular function GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
molecular function GO:0019899 enzyme binding
molecular function GO:0019904 protein domain specific binding
cellular component GO:0005829 cytosol
cellular component GO:0061702 inflammasome complex
cellular component GO:0072558 NLRP1 inflammasome complex
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
Reactome
Pathway Id Pathway Name
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System
R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-622312 Inflammasomes
R-HSA-844455 The NLRP1 inflammasome
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0002726 BXGD000125 Amyloidosis Nutritional and Metabolic Diseases
C0002880 BXGD000139 Autoimmune hemolytic anemia Immune System Diseases; Hemic and Lymphatic Diseases
C0003175 BXGD000187 Anthrax disease Infections
C0003467 BXGD000194 Anxiety Behavior and Behavior Mechanisms
C0003469 BXGD000195 Anxiety Disorders Mental Disorders
C0003864 BXGD000231 Arthritis Musculoskeletal Diseases
C0003873 BXGD000236 Rheumatoid Arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C0004096 BXGD000252 Asthma Respiratory Tract Diseases; Immune System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004364 BXGD000270 Autoimmune Diseases Immune System Diseases
C0004943 BXGD000297 Behcet Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007095 BXGD000423 Carcinoid Tumor Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007102 BXGD000425 Malignant tumor of colon Digestive System Diseases; Neoplasms
C0007113 BXGD000430 Rectal Carcinoma Digestive System Diseases; Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007193 BXGD000451 Cardiomyopathy, Dilated Cardiovascular Diseases
C0007570 BXGD000467 Celiac Disease Digestive System Diseases; Nutritional and Metabolic Diseases
C0009319 BXGD000596 Colitis Digestive System Diseases
C0009402 BXGD000605 Colorectal Carcinoma Digestive System Diseases; Neoplasms
C0010346 BXGD000664 Crohn Disease Digestive System Diseases
C0011175 BXGD000701 Dehydration Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0011570 BXGD000729 Mental Depression Behavior and Behavior Mechanisms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0011603 BXGD000734 Dermatitis Skin and Connective Tissue Diseases
C0011615 BXGD000738 Dermatitis, Atopic Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Immune System Diseases
C0011847 BXGD000749 Diabetes Endocrine System Diseases
C0011849 BXGD000751 Diabetes Mellitus Nutritional and Metabolic Diseases; Endocrine System Diseases
C0011854 BXGD000753 Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases
C0011881 BXGD000760 Diabetic Nephropathy Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases; Endocrine System Diseases
C0011884 BXGD000762 Diabetic Retinopathy Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases
C0013575 BXGD000854 Ectodermal Dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014038 BXGD000878 Encephalitis Nervous System Diseases
C0014556 BXGD000932 Epilepsy, Temporal Lobe Nervous System Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015672 BXGD001011 Fatigue Pathological Conditions, Signs and Symptoms
C0015967 BXGD001030 Fever Pathological Conditions, Signs and Symptoms
C0019209 BXGD001305 Hepatomegaly Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0020097 BXGD001360 HTLV-I Infections Infections; Immune System Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0020676 BXGD001462 Hypothyroidism Endocrine System Diseases
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0021053 BXGD001476 Immune System Diseases Immune System Diseases
C0021390 BXGD001503 Inflammatory Bowel Diseases Digestive System Diseases
C0021775 BXGD001512 Intermittent Claudication Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0022575 BXGD001555 Keratoconjunctivitis Sicca Eye Diseases
C0022658 BXGD001570 Kidney Diseases Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0022660 BXGD001571 Kidney Failure, Acute Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023343 BXGD001635 Leprosy Infections
C0023348 BXGD001636 Leprosy, Lepromatous Infections
C0023473 BXGD001661 Myeloid Leukemia, Chronic Neoplasms; Hemic and Lymphatic Diseases
C0024117 BXGD001734 Chronic Obstructive Airway Disease Respiratory Tract Diseases
C0024141 BXGD001740 Lupus Erythematosus, Systemic Skin and Connective Tissue Diseases; Immune System Diseases
C0024143 BXGD001741 Lupus Nephritis Female Urogenital Diseases and Pregnancy Complications; Skin and Connective Tissue Diseases; Male Urogenital Diseases; Immune System Diseases
C0024537 BXGD001786 Malaria, Vivax Infections
C0025202 BXGD001832 melanoma Neoplasms
C0025517 BXGD001875 Metabolic Diseases Nutritional and Metabolic Diseases
C0026691 BXGD001917 Mucocutaneous Lymph Node Syndrome Skin and Connective Tissue Diseases; Hemic and Lymphatic Diseases; Cardiovascular Diseases
C0026769 BXGD001930 Multiple Sclerosis Immune System Diseases; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027697 BXGD002022 Nephritis Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027796 BXGD002037 Neuralgia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0029408 BXGD002137 Degenerative polyarthritis Musculoskeletal Diseases
C0030436 BXGD002221 Parakeratosis Skin and Connective Tissue Diseases
C0030567 BXGD002240 Parkinson Disease Nervous System Diseases
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033860 BXGD002438 Psoriasis Skin and Connective Tissue Diseases
C0034067 BXGD002456 Pulmonary Emphysema Respiratory Tract Diseases
C0034069 BXGD002458 Pulmonary Fibrosis Respiratory Tract Diseases
C0036421 BXGD002613 Systemic Scleroderma Skin and Connective Tissue Diseases
C0036690 BXGD002632 Septicemia Pathological Conditions, Signs and Symptoms; Infections
C0036983 BXGD002652 Septic Shock Pathological Conditions, Signs and Symptoms; Infections
C0037274 BXGD002676 Dermatologic disorders Skin and Connective Tissue Diseases
C0037284 BXGD002679 Skin lesion Skin and Connective Tissue Diseases
C0038002 BXGD002723 Splenomegaly Pathological Conditions, Signs and Symptoms
C0038013 BXGD002725 Ankylosing spondylitis Musculoskeletal Diseases
C0040034 BXGD002836 Thrombocytopenia Hemic and Lymphatic Diseases
C0040147 BXGD002847 Thyroiditis Endocrine System Diseases
C0040560 BXGD002875 Toxoplasmosis, Congenital Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Infections; Nervous System Diseases
C0040580 BXGD002877 Tracheal Diseases Respiratory Tract Diseases
C0042164 BXGD002965 Uveitis Eye Diseases
C0042170 BXGD002969 Uveomeningoencephalitic Syndrome Eye Diseases; Immune System Diseases; Nervous System Diseases
C0042900 BXGD003012 Vitiligo Skin and Connective Tissue Diseases
C0085096 BXGD003123 Peripheral Vascular Diseases Cardiovascular Diseases
C0085109 BXGD003125 Corneal Neovascularization Pathological Conditions, Signs and Symptoms; Eye Diseases
C0085636 BXGD003218 Photophobia Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0085669 BXGD003233 Acute leukemia Pathological Conditions, Signs and Symptoms; Neoplasms
C0085786 BXGD003252 Hamman-Rich syndrome Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases
C0149741 BXGD003354 nipple discharge
C0151480 BXGD003426 Anti-nuclear factor positive Skin and Connective Tissue Diseases
C0151908 BXGD003502 Dry skin Skin and Connective Tissue Diseases
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162323 BXGD003937 Polyarthritis Musculoskeletal Diseases
C0178468 BXGD004029 Autoimmune thyroid disease Immune System Diseases; Endocrine System Diseases
C0202117 BXGD004074 Low density lipoprotein cholesterol measurement
C0206708 BXGD004256 Cervical Intraepithelial Neoplasia Neoplasms
C0221270 BXGD004430 Acanthosis Pathological Conditions, Signs and Symptoms
C0232197 BXGD004536 Fibrillation Pathological Conditions, Signs and Symptoms; Cardiovascular Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242596 BXGD005181 Neoplasm, Residual Pathological Conditions, Signs and Symptoms; Neoplasms
C0243026 BXGD005210 Sepsis Pathological Conditions, Signs and Symptoms; Infections
C0259799 BXGD005224 Punctate keratitis Eye Diseases
C0263361 BXGD005292 Psoriasis vulgaris Skin and Connective Tissue Diseases
C0268483 BXGD005959 Tyrosinemias Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0268487 BXGD005961 Tyrosine Transaminase Deficiency Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0271737 BXGD006252 Addison's disease due to autoimmunity Immune System Diseases; Endocrine System Diseases
C0278883 BXGD006614 Metastatic melanoma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0281773 BXGD006780 Acute glaucoma
C0333463 BXGD006954 Senile Plaques Pathological Conditions, Signs and Symptoms
C0334013 BXGD006978 Phrynoderma Skin and Connective Tissue Diseases
C0343055 BXGD007593 Generalized pustular psoriasis Skin and Connective Tissue Diseases
C0344315 BXGD007666 Depressed mood Behavior and Behavior Mechanisms
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0404572 BXGD008322 Female infertility associated with anovulation Female Urogenital Diseases and Pregnancy Complications
C0409959 BXGD008400 Osteoarthritis, Knee Musculoskeletal Diseases
C0428474 BXGD008631 Serum LDL cholesterol measurement
C0456070 BXGD008863 Growth delay
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0546393 BXGD009337 Macular cutaneous amyloidosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Skin and Connective Tissue Diseases
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0553723 BXGD009416 Squamous cell carcinoma of skin Neoplasms; Skin and Connective Tissue Diseases
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0677932 BXGD009736 Progressive Neoplastic Disease
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0699790 BXGD009866 Colon Carcinoma Digestive System Diseases; Neoplasms
C0699893 BXGD009871 Skin carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0740457 BXGD010000 Malignant neoplasm of kidney Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0745091 BXGD010113 Hypereosinophilia Hemic and Lymphatic Diseases
C0750901 BXGD010242 Alzheimer Disease, Early Onset Nervous System Diseases; Mental Disorders
C0750952 BXGD010263 Biliary Tract Cancer Digestive System Diseases; Neoplasms
C0751422 BXGD010438 Hereditary Autoinflammatory Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0751495 BXGD010473 Seizures, Focal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751651 BXGD010539 Mitochondrial Diseases Nutritional and Metabolic Diseases
C0751967 BXGD010657 Multiple Sclerosis, Relapsing-Remitting Immune System Diseases; Nervous System Diseases
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0853879 BXGD010982 Invasive carcinoma of breast Neoplasms; Skin and Connective Tissue Diseases
C0856169 BXGD011096 Endothelial dysfunction
C0870082 BXGD011309 Hyperkeratosis Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C1136135 BXGD011710 Water Stress Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C1269841 BXGD012004 Keratosis lichenoides chronica Skin and Connective Tissue Diseases
C1269955 BXGD012005 Tumor Cell Invasion
C1274999 BXGD012054 Skin flap necrosis
C1292753 BXGD012226 Primary Effusion Lymphoma Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases
C1304470 BXGD012339 Generalized vitiligo Skin and Connective Tissue Diseases
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1332922 BXGD012556 Cervical Squamous Intraepithelial Neoplasia Pathological Conditions, Signs and Symptoms; Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C1378703 BXGD012933 Renal carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C1445957 BXGD013081 Serum total cholesterol measurement
C1449563 BXGD013086 Cardiomyopathy, Familial Idiopathic Cardiovascular Diseases
C1535950 BXGD013325 Gastrointestinal inflammation
C1561989 BXGD013368 Limbal stem cell deficiency Eye Diseases
C1562761 BXGD013378 Punctate epithelial keratitis Eye Diseases
C1611743 BXGD013456 Familial (FPAH)
C1704436 BXGD013564 Peripheral Arterial Diseases Cardiovascular Diseases
C1800706 BXGD013755 Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases
C1847835 BXGD014892 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) Skin and Connective Tissue Diseases
C1879362 BXGD016576 Hypertyrosinemia
C1963094 BXGD016681 Dry Skin, CTCAE
C2103602 BXGD016918 Autoimmune Primary Adrenal Insufficiency Immune System Diseases; Endocrine System Diseases
C2936719 BXGD018130 Mechanical Allodynia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2939419 BXGD018178 Secondary Neoplasm Pathological Conditions, Signs and Symptoms; Neoplasms
C2945695 BXGD018187 Limb ischemia
C3266262 BXGD018600 Multiple Chronic Conditions Pathological Conditions, Signs and Symptoms
C3267073 BXGD018613 Autoinflammatory disease
C3495559 BXGD018994 Juvenile arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3495949 BXGD019016 Locally advanced breast cancer
C3539781 BXGD019086 Progressive cGVHD
C3714757 BXGD019430 Juvenile rheumatoid arthritis Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases
C3808876 BXGD019556 PALMOPLANTAR CARCINOMA, MULTIPLE SELF-HEALING
C3860213 BXGD019844 Autoinflammatory disorder
C3875321 BXGD019874 Inflammatory dermatosis Skin and Connective Tissue Diseases
C4049281 BXGD021921 Pseudogynaecomastia
C4055183 BXGD021997 Contrast - Induced Nephropathy
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4479278 BXGD022931 AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSIS
C4511035 BXGD022995 Isolated thrombocytopenia
C4543948 BXGD023283 Localized cutaneous leishmaniasis Infections; Skin and Connective Tissue Diseases
C4551552 BXGD023346 Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1 Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C4551675 BXGD023384 Keratoderma, Palmoplantar Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C4553962 BXGD023553 Hyperkeratosis, CTCAE
C4721507 BXGD023747 Alveolitis, Fibrosing Respiratory Tract Diseases
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0000436 Glycerol 92.09
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein