adisease

Showing entry for Actinic keratosis

General Disease Information
BXGD Id	BXGD001564
Disease Name	Actinic keratosis
Disease CUI Id	C0022602
MeSH Codes	C04 C17
Disease Class Name	Neoplasms; Skin and Connective Tissue Diseases
Semantic Type	Neoplastic Process
Human Phenotype Ontology Id	HP:0001574 HP:0002664
Human Phenotype Ontology Term	Abnormality of the integument; Neoplasm
Disease Ontology Id	DOID:14566
Disease Ontology Class Name	disease of cellular proliferation
Disorder Network	disorder-protein-compound-food associations

The disease-related target proteins

Proteins

Uniport Id	BXGT Id	Protein Name	Gene	Status	Protein Class
Uniport Id	BXGT Id	Protein name	Gene	Status	Protein class
O00206	BXGT003894	Toll-like receptor 4	7099	reviewed
O14939	BXGT004115	Phospholipase D2	5338	reviewed
O75582	BXGT005137	Ribosomal protein S6 kinase alpha-5	9252	reviewed	Kinase
O75844	BXGT005156	CAAX prenyl protease 1 homolog	10269	reviewed	Enzyme
P00533	BXGT005575	Epidermal growth factor receptor	1956	reviewed	Kinase
P00568	BXGT005583	Adenylate kinase isoenzyme 1	203	reviewed	Kinase
P00751	BXGT005643	Complement factor B	629	reviewed
P01106	BXGT005730	Myc proto-oncogene protein	4609	reviewed	Transcription factor
P01112	BXGT005732	GTPase HRas	3265	reviewed	Enzyme modulator
P01133	BXGT005736	Pro-epidermal growth factor	1950	reviewed
P01375	BXGT005753	Tumor necrosis factor	7124	reviewed	Signaling
P02545	BXGT005889	Prelamin-A/C	4000	reviewed
P03956	BXGT006120	Interstitial collagenase	4312	reviewed	Enzyme
P04637	BXGT006243	Cellular tumor antigen p53	7157	reviewed	Transcription factor
P05771	BXGT006384	Protein kinase C beta type	5579	reviewed	Kinase
P08253	BXGT006757	72 kDa type IV collagenase	4313	reviewed	Enzyme
P08254	BXGT006758	Stromelysin-1	4314	reviewed	Enzyme
P08603	BXGT006798	Complement factor H	3075	reviewed
P08670	BXGT006810	Vimentin	7431	reviewed
P08779	BXGT006824	Keratin, type I cytoskeletal 16	3868	reviewed
P09488	BXGT006899	Glutathione S-transferase Mu 1	2944	reviewed
P10275	BXGT007552	Androgen receptor	367	reviewed	Nuclear receptor
P10415	BXGT007567	Apoptosis regulator Bcl-2	596	reviewed	Signaling
P11166	BXGT007661	Solute carrier family 2, facilitated glucose transporter member 1	6513	reviewed	Transporter
P11473	BXGT007709	Vitamin D3 receptor	7421	reviewed	Nuclear receptor
P11802	BXGT007750	Cyclin-dependent kinase 4	1019	reviewed	Kinase
P12004	BXGT007766	Proliferating cell nuclear antigen	5111	reviewed	Nucleic acid binding
P14679	BXGT008039	Tyrosinase	7299	reviewed	Enzyme
P15056	BXGT008075	Serine/threonine-protein kinase B-raf	673	reviewed	Kinase
P16144	BXGT008200	Integrin beta-4	3691	reviewed	Receptor
P17252	BXGT008294	Protein kinase C alpha type	5578	reviewed	Kinase
P19971	BXGT008537	Thymidine phosphorylase	1890	reviewed	Enzyme
P20930	BXGT008616	Filaggrin	2312	reviewed	Cellular structure
P22033	BXGT008721	Methylmalonyl-CoA mutase, mitochondrial	4594	reviewed	Enzyme
P22607	BXGT008784	Fibroblast growth factor receptor 3	2261	reviewed	Kinase
P27361	BXGT009176	Mitogen-activated protein kinase 3	5595	reviewed	Kinase
P28482	BXGT009263	Mitogen-activated protein kinase 1	5594	reviewed	Kinase
P29965	BXGT009388	CD40 ligand	959	reviewed	Signaling
P30086	BXGT009400	Phosphatidylethanolamine-binding protein 1	5037	reviewed	Enzyme modulator
P30872	BXGT009474	Somatostatin receptor type 1	6751	reviewed	G-protein coupled receptor
P30874	BXGT009475	Somatostatin receptor type 2	6752	reviewed	G-protein coupled receptor
P35354	BXGT009816	Prostaglandin G/H synthase 2	5743	reviewed	Enzyme
P35869	BXGT009877	Aryl hydrocarbon receptor	196	reviewed	Transcription factor
P38936	BXGT010074	Cyclin-dependent kinase inhibitor 1	1026	reviewed
P39900	BXGT010148	Macrophage metalloelastase	4321	reviewed	Enzyme
P40763	BXGT010202	Signal transducer and activator of transcription 3	6774	reviewed	Nucleic acid binding
P42336	BXGT010302	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	5290	reviewed	Kinase
P43246	BXGT010371	DNA mismatch repair protein Msh2	4436	reviewed	Nucleic acid binding
P46108	BXGT010509	Adapter molecule crk	1398	reviewed
P48023	BXGT010604	Tumor necrosis factor ligand superfamily member 6	356	reviewed	Signaling
P49917	BXGT010765	DNA ligase 4	3981	reviewed
P50591	BXGT010814	Tumor necrosis factor ligand superfamily member 10	8743	reviewed	Signaling
P50897	BXGT010823	Palmitoyl-protein thioesterase 1	5538	reviewed	Enzyme
P51531	BXGT010851	Probable global transcription activator SNF2L2	6595	reviewed	Epigenetic regulator
P52789	BXGT010954	Hexokinase-2	3099	reviewed	Kinase
P53041	BXGT010968	Serine/threonine-protein phosphatase 5	5536	reviewed
P54819	BXGT011084	Adenylate kinase 2, mitochondrial	204	reviewed	Kinase
P56945	BXGT011206	Breast cancer anti-estrogen resistance protein 1	9564	reviewed
P61024	BXGT011350	Cyclin-dependent kinases regulatory subunit 1	1163	reviewed	Enzyme modulator
Q01726	BXGT012610	Melanocyte-stimulating hormone receptor	4157	reviewed	G-protein coupled receptor
Q01831	BXGT012621	DNA repair protein complementing XP-C cells	7508	reviewed	Nucleic acid binding
Q07869	BXGT012945	Peroxisome proliferator-activated receptor alpha	5465	reviewed	Nuclear receptor
Q07973	BXGT012952	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	1591	reviewed	Enzyme
Q13155	BXGT013320	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	7965	reviewed
Q13485	BXGT013363	Mothers against decapentaplegic homolog 4	4089	reviewed	Transcription factor
Q16539	BXGT013634	Mitogen-activated protein kinase 14	1432	reviewed	Kinase
Q53EL6	BXGT015008	Programmed cell death protein 4	27250	reviewed	Nucleic acid binding
Q8NBS9	BXGT018543	Thioredoxin domain-containing protein 5	81567	reviewed
Q96EB6	BXGT019646	NAD-dependent protein deacetylase sirtuin-1	23411	reviewed	Epigenetic regulator
Q9BZS1	BXGT020203	Forkhead box protein P3	50943	reviewed
Q9GZZ9	BXGT020430	Ubiquitin-like modifier-activating enzyme 5	79876	reviewed	Enzyme
Q9NP58	BXGT021143	ATP-binding cassette sub-family B member 6, mitochondrial	10058	reviewed	Transporter
Q9NR97	BXGT021182	Toll-like receptor 8	51311	reviewed
Q9NYK1	BXGT021258	Toll-like receptor 7	51284	reviewed
Q9NZQ7	BXGT021281	Programmed cell death 1 ligand 1	29126	reviewed	Receptor
Q92482	BXGT022676	Aquaporin-3	360	reviewed	Ion channel
P16104	BXGT024571	Histone H2AX	3014	reviewed	Nucleic acid binding
Q12888	BXGT024878	TP53-binding protein 1	7158	reviewed	Epigenetic regulator
Q8N8Q3	BXGT025150	Endonuclease V	284131	reviewed
Q9UIJ7	BXGT026029	GTP:AMP phosphotransferase AK3, mitochondrial	50808	reviewed	Kinase
P00403	BXGT026137	Cytochrome c oxidase subunit 2	4513	reviewed	Enzyme

The disease-related compounds

Compounds

BXGC Id	Compound Name	Structure	Molecular Weight	Number of targets^{?Number of times compound connecting the disease , higher numbers indicate the compound is more associated with the disease}

The disease-related foods

Foods

BXGF Id	Food Name	Scientific Name	Food Group	Number of compounds in food^{?Number of compounds in food that connecting disease, higher numbers indicate the more compounds in food are more associated with the dusease}