Showing entry for Probable global transcription activator SNF2L2


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010851
Protein NameProbable global transcription activator SNF2L2
Uniport IdP51531
GeneSMARCA2
Gene Id6595
DomainBRK; Bromodomain; Helicase_C; HSA; QLQ; SnAC; SNF2_N
Pfam PF07533   PF00439   PF00271   PF07529   PF08880   PF14619   PF00176  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
5. Organismal Systems 5.10 Environmental adaptation hsa04714 Thermogenesis
6. Human Diseases 6.2 Cancers: Specific types hsa05225 Hepatocellular carcinoma
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0043044 ATP-dependent chromatin remodeling
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0008285 negative regulation of cell population proliferation
Biological Process GO:0045892 negative regulation of transcription, DNA-templated
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007399 nervous system development
Biological Process GO:0045893 positive regulation of transcription, DNA-templated
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of transcription, DNA-templated
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0007286 spermatid development
molecular function GO:0005524 ATP binding
molecular function GO:0003682 chromatin binding
molecular function GO:0003677 DNA binding
molecular function GO:0008094 DNA-dependent ATPase activity
molecular function GO:0004386 helicase activity
molecular function GO:0042393 histone binding
molecular function GO:0003713 transcription coactivator activity
molecular function GO:0000976 transcription regulatory region sequence-specific DNA binding
cellular component GO:0045111 intermediate filament cytoskeleton
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0071565 nBAF complex
cellular component GO:0071564 npBAF complex
cellular component GO:0000790 nuclear chromatin
cellular component GO:0005654 nucleoplasm
cellular component GO:0005634 nucleus
cellular component GO:0016514 SWI/SNF complex
Reactome
Pathway Id Pathway Name
R-HSA-212436 Generic Transcription Pathway
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0001418 BXGD000050 Adenocarcinoma Neoplasms
C0001807 BXGD000077 Aggressive behavior Behavior and Behavior Mechanisms
C0002170 BXGD000105 Alopecia Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases
C0002312 BXGD000107 alpha-Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C0003537 BXGD000208 Aphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0004114 BXGD000255 Astrocytoma Neoplasms
C0004352 BXGD000269 Autistic Disorder Mental Disorders
C0005744 BXGD000330 Blepharophimosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007097 BXGD000424 Carcinoma Neoplasms
C0007114 BXGD000431 Malignant neoplasm of skin Neoplasms; Skin and Connective Tissue Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0007137 BXGD000445 Squamous cell carcinoma Neoplasms
C0007398 BXGD000465 Catatonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0009207 BXGD000593 Cockayne Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Musculoskeletal Diseases; Nervous System Diseases
C0010068 BXGD000648 Coronary heart disease Cardiovascular Diseases
C0010417 BXGD000670 Cryptorchidism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Male Urogenital Diseases; Endocrine System Diseases
C0010606 BXGD000677 Adenoid Cystic Carcinoma Neoplasms
C0013336 BXGD000815 Dwarfism Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Endocrine System Diseases
C0013528 BXGD000851 Echolalia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0013595 BXGD000858 Eczema Skin and Connective Tissue Diseases
C0014859 BXGD000961 Esophageal Neoplasms Digestive System Diseases; Neoplasms
C0015544 BXGD001003 Failure to Thrive Pathological Conditions, Signs and Symptoms
C0015934 BXGD001026 Fetal Growth Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications
C0017636 BXGD001131 Glioblastoma Neoplasms
C0017638 BXGD001132 Glioma Neoplasms
C0019196 BXGD001301 Hepatitis C Digestive System Diseases; Infections
C0019270 BXGD001311 Hernia Pathological Conditions, Signs and Symptoms
C0020678 BXGD001463 Hypotrichosis Skin and Connective Tissue Diseases
C0022602 BXGD001564 Actinic keratosis Neoplasms; Skin and Connective Tissue Diseases
C0022661 BXGD001572 Kidney Failure, Chronic Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0023418 BXGD001642 leukemia Neoplasms
C0023467 BXGD001658 Leukemia, Myelocytic, Acute Neoplasms
C0023890 BXGD001713 Liver Cirrhosis Pathological Conditions, Signs and Symptoms; Digestive System Diseases
C0024121 BXGD001735 Lung Neoplasms Neoplasms; Respiratory Tract Diseases
C0024433 BXGD001771 Macrostomia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0024623 BXGD001791 Malignant neoplasm of stomach Digestive System Diseases; Neoplasms
C0025202 BXGD001832 melanoma Neoplasms
C0025362 BXGD001866 Mental Retardation Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0025568 BXGD001877 Metaplasia Pathological Conditions, Signs and Symptoms
C0025958 BXGD001882 Microcephaly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0026351 BXGD001900 Moderate intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0026499 BXGD001905 Monosomy Pathological Conditions, Signs and Symptoms
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026884 BXGD001945 Mutism Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0027651 BXGD002009 Neoplasms Neoplasms
C0027830 BXGD002046 neurofibroma Neoplasms; Nervous System Diseases
C0027831 BXGD002047 Neurofibromatosis 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0028754 BXGD002082 Obesity Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases
C0028945 BXGD002099 oligodendroglioma Neoplasms
C0033578 BXGD002408 Prostatic Neoplasms Neoplasms; Male Urogenital Diseases
C0034013 BXGD002450 Precocious Puberty Endocrine System Diseases
C0035934 BXGD002572 Rubinstein-Taybi Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036439 BXGD002615 Scoliosis, unspecified Musculoskeletal Diseases
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0038220 BXGD002740 Status Epilepticus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0039101 BXGD002790 synovial sarcoma Neoplasms
C0042769 BXGD002999 Virus Diseases Infections
C0149925 BXGD003387 Small cell carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0150080 BXGD003402 Social Communication Disorder Mental Disorders
C0152013 BXGD003516 Adenocarcinoma of lung (disorder) Neoplasms
C0152018 BXGD003518 Esophageal carcinoma Digestive System Diseases; Neoplasms
C0162678 BXGD003974 Neurofibromatoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neoplasms; Nervous System Diseases
C0175754 BXGD004015 Agenesis of corpus callosum Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C0178874 BXGD004037 Tumor Progression Pathological Conditions, Signs and Symptoms
C0205698 BXGD004109 Undifferentiated carcinoma Neoplasms
C0206623 BXGD004189 Adenosquamous carcinoma Neoplasms
C0206704 BXGD004254 Carcinoma, Large Cell Neoplasms
C0206743 BXGD004285 Rhabdoid Tumor Neoplasms
C0220650 BXGD004310 Metastatic malignant neoplasm to brain Pathological Conditions, Signs and Symptoms; Neoplasms; Nervous System Diseases
C0221357 BXGD004449 Brachydactyly Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases
C0235974 BXGD004796 Pancreatic carcinoma Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0242379 BXGD005157 Malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C0262444 BXGD005244 Abnormality of the dentition Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Stomatognathic Diseases
C0262584 BXGD005256 Carcinoma, Small Cell Neoplasms
C0265338 BXGD005522 Coffin-Siris syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C0265354 BXGD005529 CHARGE Syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases
C0265372 BXGD005532 Fetal hydantoin syndrome Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C0278660 BXGD006555 Adult Synovial Sarcoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0278996 BXGD006621 Malignant Head and Neck Neoplasm Neoplasms
C0279070 BXGD006625 Adult Oligodendroglioma Neoplasms
C0279626 BXGD006657 Squamous cell carcinoma of esophagus Digestive System Diseases; Neoplasms
C0279628 BXGD006659 Adenocarcinoma Of Esophagus Digestive System Diseases; Neoplasms
C0279702 BXGD006685 Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C0279982 BXGD006702 Childhood Synovial Sarcoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0280475 BXGD006749 Childhood Oligodendroglioma Neoplasms
C0282160 BXGD006797 Aplasia Cutis Congenita Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0333307 BXGD006946 Superficial ulcer Pathological Conditions, Signs and Symptoms
C0345967 BXGD007756 Malignant mesothelioma Neoplasms; Respiratory Tract Diseases
C0346647 BXGD007832 Malignant neoplasm of pancreas Digestive System Diseases; Neoplasms; Endocrine System Diseases
C0349588 BXGD007933 Short stature
C0375023 BXGD007970 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0376545 BXGD008002 Hematologic Neoplasms Neoplasms; Hemic and Lymphatic Diseases
C0393702 BXGD008124 Myoclonic Astatic Epilepsy Nervous System Diseases
C0423110 BXGD008471 Downward slant of palpebral fissure
C0423112 BXGD008472 Short palpebral fissure
C0424503 BXGD008532 Dysmorphic facies
C0427460 BXGD008616 Red cell distribution width determination
C0431448 BXGD008691 Absent eyebrow Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases
C0432072 BXGD008718 Dysmorphic features
C0476089 BXGD008977 Endometrial Carcinoma Neoplasms; Female Urogenital Diseases and Pregnancy Complications
C0524528 BXGD009229 Pervasive Development Disorder Mental Disorders
C0541764 BXGD009259 Delayed bone age
C0545053 BXGD009323 Advanced bone age
C0546837 BXGD009343 Malignant neoplasm of esophagus Digestive System Diseases; Neoplasms
C0557874 BXGD009444 Global developmental delay
C0578038 BXGD009542 Thin lips
C0596263 BXGD009639 Carcinogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0598766 BXGD009669 Leukemogenesis Pathological Conditions, Signs and Symptoms; Neoplasms
C0684249 BXGD009790 Carcinoma of lung Neoplasms; Respiratory Tract Diseases
C0729582 BXGD009931 Floating-harbor syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Cardiovascular Diseases
C0751396 BXGD010425 Well Differentiated Oligodendroglioma Neoplasms
C0812413 BXGD010847 Malignant Pleural Mesothelioma Neoplasms; Respiratory Tract Diseases
C0877024 BXGD011330 Schimke immunoosseous dysplasia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Female Urogenital Diseases and Pregnancy Complications; Musculoskeletal Diseases; Male Urogenital Diseases; Respiratory Tract Diseases; Immune System Diseases; Cardiovascular Diseases
C0877165 BXGD011338 Short phalanx of finger
C0973461 BXGD011595 Dysphasia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1136249 BXGD011715 Mental Retardation, X-Linked Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
C1142533 BXGD011758 Smooth philtrum
C1168401 BXGD011792 Squamous cell carcinoma of the head and neck Neoplasms
C1269955 BXGD012005 Tumor Cell Invasion
C1303073 BXGD012322 Nicolaides Baraitser syndrome Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C1304746 BXGD012343 RDW - Red blood cell distribution width result
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1306460 BXGD012362 Primary malignant neoplasm of lung Neoplasms; Respiratory Tract Diseases
C1332977 BXGD012569 Childhood Leukemia Neoplasms
C1456873 BXGD013129 alpha^+^ Thalassemia Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Hemic and Lymphatic Diseases
C1458155 BXGD013136 Mammary Neoplasms Neoplasms; Skin and Connective Tissue Diseases
C1510586 BXGD013176 Autism Spectrum Disorders Mental Disorders
C1527366 BXGD013280 Salaam Seizures Nervous System Diseases
C1535926 BXGD013322 Neurodevelopmental Disorders Mental Disorders
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1623038 BXGD013475 Cirrhosis Pathological Conditions, Signs and Symptoms
C1827524 BXGD013773 Wide spaced nipples
C1835884 BXGD014061 Triangular face
C1837084 BXGD014195 Short metacarpal
C1837404 BXGD014229 High, narrow palate
C1837770 BXGD014270 Sparse hair
C1839739 BXGD014400 Thick lower lip vermilion
C1840069 BXGD014433 Sandal gap
C1840077 BXGD014434 Anteverted nostril
C1842366 BXGD014512 Low anterior hairline
C1843108 BXGD014556 Short palm
C1844809 BXGD014677 Thick nasal alae
C1844813 BXGD014679 Widely spaced teeth
C1845055 BXGD014705 ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, NONDELETION TYPE, X-LINKED Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Hemic and Lymphatic Diseases
C1848207 BXGD014916 Poor speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1849020 BXGD014996 Short metatarsal
C1849089 BXGD015004 Broad forehead
C1849667 BXGD015073 Wide nasal base
C1850630 BXGD015162 Broad distal phalanx of finger
C1853246 BXGD015323 Eversion of lower lip
C1853738 BXGD015357 Long eyelashes
C1854111 BXGD015381 Broad philtrum
C1854882 BXGD015439 Absent speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C1857042 BXGD015669 Sparse scalp hair
C1859115 BXGD015853 Prominent interphalangeal joints
C1865014 BXGD016282 Long philtrum
C1868571 BXGD016508 Highly arched eyebrow
C2062441 BXGD016897 Influenza A
C2169806 BXGD016935 recurrent muscle twitches (symptom) Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2237142 BXGD016960 Moderate global developmental delay
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2243051 BXGD017008 Large head (disorder)
C2316810 BXGD017030 Chronic kidney disease stage 5 Female Urogenital Diseases and Pregnancy Complications; Male Urogenital Diseases
C2673670 BXGD017220 Curly eyelashes
C2675021 BXGD017264 Narrow palpebral fissure
C2919142 BXGD017867 Short Stature, CTCAE
C3281201 BXGD018889 MENTAL RETARDATION, AUTOSOMAL DOMINANT 12 Pathological Conditions, Signs and Symptoms; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases; Mental Disorders; Stomatognathic Diseases; Behavior and Behavior Mechanisms
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3887461 BXGD019876 Head and Neck Carcinoma Neoplasms
C3887485 BXGD019877 MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1
C3887489 BXGD019879 Clubbing of toes
C3887524 BXGD019892 Skin Erosion Skin and Connective Tissue Diseases
C4021611 BXGD020697 Abnormality of epiphysis morphology
C4021785 BXGD020778 Abnormality of the metacarpal bones Musculoskeletal Diseases
C4023721 BXGD021252 Abnormal hair pattern
C4024890 BXGD021458 Excessive wrinkled skin
C4025790 BXGD021791 Specific learning disability
C4049796 BXGD021951 Abnormality of cardiovascular system morphology Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Cardiovascular Diseases
C4086152 BXGD022123 Childhood Astrocytoma Neoplasms
C4316903 BXGD022711 Absence Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C4511452 BXGD023002 Sporadic Parkinson disease Nervous System Diseases
C4551563 BXGD023351 Microcephaly (physical finding)
C4551564 BXGD023352 Narrow nasal bridge
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0008707 Isoliquiritigenin 256.25
BXGC0042678 Ambrosin 246.13
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein