Showing entry for Palmitoyl-protein thioesterase 1


　 　 　 　 　 　 　 　 　 　 　 　
General Target Information
BXGT IdBXGT010823
Protein NamePalmitoyl-protein thioesterase 1
Uniport IdP50897
GenePPT1
Gene Id5538
DomainPalm_thioest
Pfam PF02089  
OrganismHomo sapiens (Human)
Target protein  affiliated  biological  pathways
KEGG
Class Subclass KEGG Id Pathway Name
1. Metabolism 1.3 Lipid metabolism hsa00062 Fatty acid elongation
1. Metabolism 1.0 Global and overview maps hsa01100 Metabolic pathways
1. Metabolism 1.0 Global and overview maps hsa01212 Fatty acid metabolism
4. Cellular Processes 4.1 Transport and catabolism hsa04142 Lysosome
Gene Ontology
GO Type GO Id Gene Ontology
Biological Process GO:0008344 adult locomotory behavior
Biological Process GO:0008306 associative learning
Biological Process GO:0007420 brain development
Biological Process GO:0044257 cellular protein catabolic process
Biological Process GO:0046949 fatty-acyl-CoA biosynthetic process
Biological Process GO:0007625 grooming behavior
Biological Process GO:0016042 lipid catabolic process
Biological Process GO:0007042 lysosomal lumen acidification
Biological Process GO:0031579 membrane raft organization
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0030308 negative regulation of cell growth
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0007399 nervous system development
Biological Process GO:0048666 neuron development
Biological Process GO:0007269 neurotransmitter secretion
Biological Process GO:0006907 pinocytosis
Biological Process GO:0048549 positive regulation of pinocytosis
Biological Process GO:0048260 positive regulation of receptor-mediated endocytosis
Biological Process GO:0030163 protein catabolic process
Biological Process GO:0002084 protein depalmitoylation
Biological Process GO:0015031 protein transport
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0032429 regulation of phospholipase A2 activity
Biological Process GO:0050803 regulation of synapse structure or activity
Biological Process GO:0050896 response to stimulus
Biological Process GO:0030149 sphingolipid catabolic process
Biological Process GO:0007601 visual perception
molecular function GO:0035727 lysophosphatidic acid binding
molecular function GO:0008474 palmitoyl-(protein) hydrolase activity
molecular function GO:0016290 palmitoyl-CoA hydrolase activity
molecular function GO:0120146 sulfatide binding
molecular function GO:0016790 thiolester hydrolase activity
cellular component GO:0030424 axon
cellular component GO:0005829 cytosol
cellular component GO:0030425 dendrite
cellular component GO:0070062 extracellular exosome
cellular component GO:0005576 extracellular region
cellular component GO:0005794 Golgi apparatus
cellular component GO:0043231 intracellular membrane-bounded organelle
cellular component GO:0043202 lysosomal lumen
cellular component GO:0005764 lysosome
cellular component GO:0016020 membrane
cellular component GO:0045121 membrane raft
cellular component GO:0043025 neuronal cell body
cellular component GO:0005634 nucleus
cellular component GO:0008021 synaptic vesicle
Reactome
Pathway Id Pathway Name
R-HSA-1430728 Metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-75105 Fatty acyl-CoA biosynthesis
R-HSA-8978868 Fatty acid metabolism
Target protein-related  diseases
Disease
CUI Id BXGD Id Disease Name Disease Class
C0002395 BXGD000111 Alzheimer's Disease Nervous System Diseases; Mental Disorders
C0004134 BXGD000256 Ataxia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0006142 BXGD000374 Malignant neoplasm of breast Neoplasms; Skin and Connective Tissue Diseases
C0006826 BXGD000408 Malignant Neoplasms Neoplasms
C0007112 BXGD000429 Adenocarcinoma of prostate Neoplasms; Male Urogenital Diseases
C0007131 BXGD000441 Non-Small Cell Lung Carcinoma Neoplasms; Respiratory Tract Diseases
C0008073 BXGD000518 Developmental Disabilities Mental Disorders
C0009404 BXGD000606 Colorectal Neoplasms Digestive System Diseases; Neoplasms
C0011581 BXGD000733 Depressive disorder Mental Disorders
C0014175 BXGD000904 Endometriosis Female Urogenital Diseases and Pregnancy Complications
C0015397 BXGD000983 Disorder of eye Eye Diseases
C0015644 BXGD001008 Muscular fasciculation Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0017205 BXGD001105 Gaucher Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0017636 BXGD001131 Glioblastoma Neoplasms
C0018213 BXGD001187 Graves Disease Eye Diseases; Immune System Diseases; Endocrine System Diseases
C0018524 BXGD001200 Hallucinations Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0018801 BXGD001226 Heart failure Cardiovascular Diseases
C0018802 BXGD001227 Congestive heart failure Cardiovascular Diseases
C0020179 BXGD001363 Huntington Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases; Mental Disorders
C0021051 BXGD001475 Immunologic Deficiency Syndromes Immune System Diseases
C0022107 BXGD001530 Irritable Mood Behavior and Behavior Mechanisms
C0022340 BXGD001536 Late-Infantile Neuronal Ceroid Lipfuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0022602 BXGD001564 Actinic keratosis Neoplasms; Skin and Connective Tissue Diseases
C0022797 BXGD001586 Adult Neuronal Ceroid Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0023903 BXGD001720 Liver neoplasms Digestive System Diseases; Neoplasms
C0024809 BXGD001808 Marijuana Abuse Chemically-Induced Disorders; Mental Disorders
C0026650 BXGD001913 Movement Disorders Nervous System Diseases
C0026827 BXGD001936 Muscle hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0026838 BXGD001938 Muscle Spasticity Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases; Nervous System Diseases
C0027066 BXGD001966 Myoclonus Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0027627 BXGD002006 Neoplasm Metastasis Pathological Conditions, Signs and Symptoms; Neoplasms
C0027651 BXGD002009 Neoplasms Neoplasms
C0027765 BXGD002033 nervous system disorder Nervous System Diseases
C0027819 BXGD002043 Neuroblastoma Neoplasms
C0027877 BXGD002055 Neuronal Ceroid-Lipofuscinoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0029124 BXGD002113 Optic Atrophy Eye Diseases; Nervous System Diseases
C0030193 BXGD002191 Pain Pathological Conditions, Signs and Symptoms
C0032460 BXGD002355 Polycystic Ovary Syndrome Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0033975 BXGD002447 Psychotic Disorders Mental Disorders
C0036341 BXGD002600 Schizophrenia Mental Disorders
C0036572 BXGD002625 Seizures Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0036857 BXGD002638 Severe intellectual disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0037317 BXGD002689 Sleep disturbances Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0042798 BXGD003003 Low Vision Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0042963 BXGD003018 Vomiting Pathological Conditions, Signs and Symptoms
C0085078 BXGD003118 Lysosomal Storage Diseases Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases
C0085584 BXGD003195 Encephalopathies Nervous System Diseases
C0149521 BXGD003328 Pancreatitis, Chronic Digestive System Diseases
C0151611 BXGD003447 Electroencephalogram abnormal Nervous System Diseases
C0233794 BXGD004618 Memory impairment Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Behavior and Behavior Mechanisms
C0234632 BXGD004691 Reduced visual acuity Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0235946 BXGD004789 Cerebral atrophy Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0242383 BXGD005160 Age related macular degeneration Eye Diseases
C0242422 BXGD005163 Parkinsonian Disorders Nervous System Diseases
C0266999 BXGD005725 Vesicular Stomatitis Infections; Stomatognathic Diseases; Animal Diseases
C0268281 BXGD005882 Infantile neuronal ceroid lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0271093 BXGD006162 Stargardt's disease
C0271815 BXGD006264 Postpartum Thyroiditis Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases
C0278694 BXGD006564 Disseminated neuroblastoma Neoplasms
C0278878 BXGD006609 Adult Glioblastoma Neoplasms
C0280474 BXGD006748 Childhood Glioblastoma Neoplasms
C0333068 BXGD006920 Flexion contracture Musculoskeletal Diseases
C0349204 BXGD007892 Nonorganic psychosis Mental Disorders
C0376358 BXGD007992 Malignant neoplasm of prostate Neoplasms; Male Urogenital Diseases
C0456909 BXGD008883 Blindness Pathological Conditions, Signs and Symptoms; Eye Diseases; Nervous System Diseases
C0524851 BXGD009246 Neurodegenerative Disorders Nervous System Diseases
C0542223 BXGD009274 Loss of speech Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0542476 BXGD009276 Forgetful Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C0553642 BXGD009403 Soft tissue rheumatism Pathological Conditions, Signs and Symptoms; Skin and Connective Tissue Diseases; Musculoskeletal Diseases
C0557874 BXGD009444 Global developmental delay
C0600139 BXGD009695 Prostate carcinoma Neoplasms; Male Urogenital Diseases
C0678222 BXGD009749 Breast Carcinoma Neoplasms; Skin and Connective Tissue Diseases
C0700095 BXGD009875 Central neuroblastoma Neoplasms; Nervous System Diseases
C0700201 BXGD009880 Dyssomnias Nervous System Diseases; Mental Disorders
C0742078 BXGD010055 Mass lesion of brain
C0751214 BXGD010353 Hyperalgesia, Thermal Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C0751383 BXGD010422 Juvenile Neuronal Ceroid Lipofuscinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C0848676 BXGD010883 Subfertility, Male Male Urogenital Diseases
C0851578 BXGD010925 Sleep Disorders Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders
C0854297 BXGD011014 Head deformity
C1135161 BXGD011690 Stage 4S neuroblastoma
C1269955 BXGD012005 Tumor Cell Invasion
C1306459 BXGD012361 Primary malignant neoplasm Neoplasms
C1621958 BXGD013468 Glioblastoma Multiforme Neoplasms
C1836842 BXGD014167 Psychomotor deterioration Mental Disorders
C1839025 BXGD014353 Decreased light- and dark-adapted electroretinogram amplitude
C1839364 BXGD014371 Progressive visual loss
C1847514 BXGD014868 Postnatal microcephaly
C1850451 BXGD015145 CEROID LIPOFUSCINOSIS, NEURONAL, 1 Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C1850456 BXGD015146 Progressive microcephaly
C1855685 BXGD015531 Undetectable electroretinogram
C1858120 BXGD015774 Generalized hypotonia Pathological Conditions, Signs and Symptoms; Nervous System Diseases
C2239176 BXGD016965 Liver carcinoma Digestive System Diseases; Neoplasms
C2700617 BXGD017474 Irritation - emotion Behavior and Behavior Mechanisms
C2931673 BXGD018046 Ceroid lipofuscinosis, neuronal 1, infantile Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nutritional and Metabolic Diseases; Nervous System Diseases
C2985280 BXGD018223 Blood Protein Measurement
C3665346 BXGD019278 Unspecified visual loss Pathological Conditions, Signs and Symptoms; Eye Diseases
C3714756 BXGD019429 Intellectual Disability Pathological Conditions, Signs and Symptoms; Nervous System Diseases; Mental Disorders; Behavior and Behavior Mechanisms
C3714948 BXGD019440 PACHYONYCHIA CONGENITA 3
C3811653 BXGD019662 Experimental Organism Basal Cell Carcinoma Neoplasms
C4021085 BXGD020544 Abnormality of brain morphology
C4021768 BXGD020766 Abnormality of metabolism/homeostasis
C4024710 BXGD021381 Cerebellar cortical atrophy
C4025728 BXGD021760 Increased neuronal autofluorescent lipopigment
C4072872 BXGD022008 obsolete Rod-cone dystrophy
C4086165 BXGD022126 Childhood Neuroblastoma Neoplasms
C4277690 BXGD022377 Ciliopathies Congenital, Hereditary, and Neonatal Diseases and Abnormalities
C4552810 BXGD023525 Irritability, CTCAE
C4553743 BXGD023548 Spasticity, CTCAE
C4721806 BXGD023772 Carcinoma, Basal Cell Neoplasms
C4722306 BXGD023798 Metastatic Neuroblastoma Neoplasms
C4732730 BXGD023895 Blood spots
Target protein-related  compounds
Compounds
BXGC Id Compound Name Strcuture Molecular Weight
BXGC0005513 Hexadecanoic acid 256.42
The  target protein-related  foods
Foods
BXGF Id Food Name Scientific Name Food Group Number of compound? Number of compound in food, higher numbers indicate the food are more associated with the protein